The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells

Hsin, Yi-Hong; Chen, Chunfeng; Huang, Shing Jong; Shih, Tung‐Sheng; Lai, Ping‐Shan; Chueh, Pin Ju

doi:10.1016/j.toxlet.2008.04.015

Cited by 776 publications

(469 citation statements)

References 48 publications

Supporting

Mentioning

420

Contrasting

Unclassified

Order By: Relevance

“…Others assumed that it was related to the formation of free radicals and subsequent free radical-induced membrane damage. Hsin et al (2008) confirmed that apoptosis induced by nano-Ag was associated with the generation of reactive oxygen species (ROS) and JNK activation Hsin et al 2008). Images obtained from SEM here revealed the damage of nano-Ag to cellular structure in all these three bacteria.…”

Section: Discussionsupporting

confidence: 59%

Toxicity effects of four typical nanomaterials on the growth of Escherichia coli, Bacillus subtilis and Agrobacterium tumefaciens

Wang

et al. 2011

Environ Earth Sci

View full text Add to dashboard Cite

To offer an insight into the toxicity of nanomaterials (NM) on the growth of bacteria, Escherichia coli (E. coli), Bacillus subtilis (B. subtilis) and Agrobacterium tumefaciens (A. tumefaciens) were exposed to nanoAu, nano-Ag, nano-Fe and fullerene (C 60 ) in this study. As an effective bactericide, nano-Ag induced high toxicity on these three bacteria; C 60 could inhibit their growth; however, B. subtilis and E. coli could recover as exposure time extended. Nano-Au and nano-Fe had hardly any effect on three bacteria. A. tumefaciens showed the lowest resistance and slowest growth rate during exposure. Images obtained by scanning electron microscope (SEM) revealed that nano-Ag could cause damage to the cell structure of three bacteria at 1 lg/mL. Slight damage on E. coli was found when exposed to C 60 , whereas no obvious physical damage was found after exposure to nano-Au or nano-Fe. It is assumed that surface activities of NM might be responsible for the different toxic effects on these bacteria.

show abstract

Section: Discussionsupporting

confidence: 59%

Toxicity effects of four typical nanomaterials on the growth of Escherichia coli, Bacillus subtilis and Agrobacterium tumefaciens

Wang

et al. 2011

Environ Earth Sci

View full text Add to dashboard Cite

show abstract

“…ROS scavenger could markedly inhibit the JNK, c-Jun and p53 activity, indicating that ROS could be upstream effectors of JNK and p53 (Liu and Sun 2010). Hsin et al (2008) found that nano silverinduced apoptosis was mediated by the ROS via JNK and p53 activation. ROS could also directly activate p53, most probably by the induction of DNA damage (Simbula et al 2007;Turkez and Togar 2010;Turkez and Geyikoglu 2010;Turkez et al 2012).…”

Section: Discussionmentioning

confidence: 96%

The Risk Evaluation of Tungsten Oxide Nanoparticles in Cultured Rat Liver Cells for Its Safe Applications in Nanotechnology

Türkez

Sönmez

Turkez

et al. 2014

Braz. arch. biol. technol.

View full text Add to dashboard Cite

show abstract

“…The study demonstrated that the DNA damage is due to silver nanoparticle deposition and interaction with DNA followed by cell cycle arrest in G 2 /M phase [121]. Cytotoxic study on fibroblast cells NIH3T3 showed that silver nanoparticles induced mitochondria-dependent apoptosis associated with JNK activation and reactive oxygen species [122]. Toxicity of silver nanoparticles was also evaluated on human hematoma cell line HepG2 using micronucleus test, viability assay and DNA microarray analysis [123].…”

Section: Effects On Cell Linesmentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

View full text Add to dashboard Cite

Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The review also presents a detailed and elaborative discussion on the toxicity imposed by different types of nanoparticles including carbon nanotubes, gold nanoparticles, silver nanoparticles, quantum dots, fullerenes, aluminium nanoparticles, zinc nanoparticles, iron nanoparticles, titanium nanoparticles and silica nanoparticles. It discusses the in vitro and in vivo toxological effects of nanoparticles on bacteria, microalgae, zebrafish, crustacean, fish, rat, mouse, pig, guinea pig, human cell lines and human. It also discusses toxological effects on organs such as liver, kidney, spleen, sperm, neural tissues, liver lysosomes, spleen macrophages, glioblastoma cells, hematoma cells and various mammalian cell lines. It provides information about the effects of nanoparticles on the gene-expression, growth and reproduction of the organisms.

show abstract

The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells

Cited by 776 publications

References 48 publications

Toxicity effects of four typical nanomaterials on the growth of Escherichia coli, Bacillus subtilis and Agrobacterium tumefaciens

Toxicity effects of four typical nanomaterials on the growth of Escherichia coli, Bacillus subtilis and Agrobacterium tumefaciens

The Risk Evaluation of Tungsten Oxide Nanoparticles in Cultured Rat Liver Cells for Its Safe Applications in Nanotechnology

In vitro and in vivo toxicity assessment of nanoparticles

Contact Info

Product

Resources

About