The Apoptotic Properties of Leaf Extracts of Simarouba glauca against Human Leukemic Cancer Cells

Vikas, Biba; Kunjiraman, Sujathan; Rajam, Suja Somasekharan Nair; Anil, Sukumaran

doi:10.31557/apjcp.2021.22.4.1305

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…In the present study, it is strongly suggested that the markedly elevated WBC counts, lymphocytes and monocytes differentials observed at varied doses may not be unconnected with cellular in ammatory responses elicited by inherent phytochemicals of the leaf extracts of S. glauca [17,25,34], which may have signaled, stimulated and activated the release of T-helper cells, macrophage colony stimulating factor, interleukins IL-2 IL-4 and IL-5, proliferation, differentiation and maturation of committed stem cells responsible for the production of white blood cells and differentials [35,36].…”

Section: Discussionmentioning

confidence: 56%

“…The stem-bark and leaf extracts of S. glauca contain triterpenes, useful in curing amoebiasis, diarrhea and malaria [15]. Chemicals present in leaf, fruit, pulp and seed of S. glauca have been reported to possess analgesic, anticancer, antimicrobial, antiviral, astringent, cardio-protective, emmenagogue, stomachic, tonic, vermifuge properties [15][16][17][18]. The present study focused on the toxicological evaluation of leaf extracts of S. glauca on some selected hematological indices of male Wistar rat Materials And Methods Collection of S. glauca leaves and preparation of Extracts Leaves of S. glauca were collected from Cercobela Farms®, Ubiaja, Esan South East Local Government Area of Edo State, Nigeria.…”

Section: Introductionmentioning

confidence: 99%

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Comparative toxicity study of aqueous, ethanol and methanol leaf extracts of Simarouba glauca on hematological indices in adult normotensive male Wistar rats

Osagie-Eweka

Orhue

Moke

et al. 2023

Preprint

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Background The study focused on the toxicological evaluation of leaf extracts of S. glauca on some hematological indices of male Wistar rats. Methods Thirty (30) male Wistar rats were divided into ten groups of three rats each. Test rats were given AESG, EESG or MESG at doses of 500, 1000 and 2000 mg/kg body weight respectively; the control group was provided with food and water ad libitum daily for thirty (30) days. At the end of the study, the fasted rats were sacrificed and haematological assessment was conducted. Results The data obtained indicates elevated (P ˂ 0.05) RBC levels of experimental rat administered EESG and MESG at 500, 1000 and 2000 mg respectively. Reduced (P ˂ 0.05) haemoglobin concentration at AESG and MESG 500 mg, AESG, EESG and MESG 1000 mg; EESG 2000 mg. The haematocrit/PCV levels where only slightly reduced (P ˂ 0.05) and elevated (P ˂ 0.05) at EESG 1000 and 2000 mg respectively. Platelets count was elevated (P ˂ 0.05) at MESG 500 mg, lowered at AESG 1000 mg and EESG 2000 mg. The WBC count was elevated (P ˂ 0.05) at AESG and EESG 1000 mg; elevated (P ˂ 0.05) at EESG and MESG 2000 mg. The lymphocytes count was elevated (P ˂ 0.05) at EESG 500, 1000 & 2000 mg; at AESG 1000 mg. The monocytes count was elevated (P ˂ 0.05) at AESG 500, 1000 & 2000 mg, elevated (P ˂ 0.05) AESG and EESG 1000 & 2000 mg respectively, and elevated (P ˂ 0.05) at MESG 2000 mg. Conclusion Oral administration of leaf extracts of S. glauca, especially at higher doses elicit disturbances in haematological indices.

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Comparative toxicity study of aqueous, ethanol and methanol leaf extracts of Simarouba glauca on hematological indices in adult normotensive male Wistar rats

Osagie-Eweka

Orhue

Moke

et al. 2023

Preprint

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Exploration of Medicinal Properties and Metabolite Diversity Between Different Petiole Types of Simarouba Glauca: A Nontargeted Metabolomics Approach

Kandaswamy,

Kannathasan,

Selvakumar

et al. 2024

Environmental Quality Mgmt

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Comparative metabolomics is a powerful technique to unveil variabilities in metabolic composition between different plant types of the same species. Thus, unveiling the unique and common metabolites between plant types and unique medicinal properties has the potential to utilize the specific plant type in modern medicine. However, up to date, no study reports metabolite composition and medicinal properties of different color petiole types of Simarouba glauca (S. glauca), which is known for its potential pharmaceutical properties. In this study, we aimed to perform a metabolomic investigation on two different petiole types of S. glauca to unveil the unique and common metabolites and their therapeutic properties between these petiole plant types. In specific, we conducted a comprehensive metabolomic analysis of the green petiole (GP) and red petiole (RP) of S. glauca, that revealed 43 unique metabolites between both petiole types. The differentially accumulated metabolite analysis disclosed five differentially accumulated metabolites between RP and GP, in which two are highly accumulated in GP (4‐Amino‐1,5‐pentandioic acid and 2‐Myristynoyl pantetheine), and one (5‐Hydroxymethylfurfural) in RP. Furthermore, the chemical classification of identified metabolites resulted in 27 distinct chemical classes, with fatty acids and amino acids being notably enriched. Functional annotation highlighted the wound healing and antibacterial attributes of GP and the antipruritic and antiviral properties of RP. The pathway enrichment analysis revealed the involvement of the identified metabolites in cutin, suberin, and wax biosynthesis, along with fatty acid biosynthesis. Moreover, RP exhibited a higher abundance of anticancer metabolites compared to GP. Overall, the findings of this study offer valuable insights into the metabolic disparities, metabolite role in color variation, and medicinal potentials of different petiole types of S. glauca and underscore their promising pharmaceutical applications.

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Biogenic synthesis of gold nanoparticles using bael fruit juice and its efficacy against human A-549 lung cancer cell line

Devendrapandi

Sahay

Padmanaban

et al. 2023

Inorganic Chemistry Communications

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The Apoptotic Properties of Leaf Extracts of Simarouba glauca against Human Leukemic Cancer Cells

Abstract: more than 170 species of trees and bushes of pantropical distribution (Alves et al., 2014). Its common names are Lakshmi Taru and paradise-tree. A molecular phylogeny of the family was reported in 2007, data revealed with the relationships within the family (Clayton et al., 2007).

Cited by 7 publications

References 28 publications

Comparative toxicity study of aqueous, ethanol and methanol leaf extracts of Simarouba glauca on hematological indices in adult normotensive male Wistar rats

Comparative toxicity study of aqueous, ethanol and methanol leaf extracts of Simarouba glauca on hematological indices in adult normotensive male Wistar rats

Exploration of Medicinal Properties and Metabolite Diversity Between Different Petiole Types of Simarouba Glauca: A Nontargeted Metabolomics Approach

Biogenic synthesis of gold nanoparticles using bael fruit juice and its efficacy against human A-549 lung cancer cell line

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