The Apparent Relation between Plasma 25-Hydroxyvitamin D and Insulin Resistance Is Largely Attributable to Central Adiposity in Overweight and Obese Adults

Abstract

Central adiposity drives the association between plasma 25(OH)D and insulin resistance in overweight and obese adults. The trial was registered at clinicaltrials.gov as NCT00812409.

Associations of 25-hydroxyvitamin D with markers of inflammation, insulin resistance and obesity in black and white community-dwelling adults

“…Consistent with the findings of the current study, prior studies found an inverse association of serum 25(OH)D concentrations with insulin resistance [1], [5], [6] and pro-inflammatory markers such as IL-6 and CRP [14], [15]. Similarly, multiple prior studies have shown an inverse association of BMI with 25(OH)D, which is attributed to the fat-soluble nature of vitamin D and sequestration into adipose tissue [2], [16]. However, these previous studies included relatively low numbers of black individuals, precluding definitive examination of race differences.…”

Associations of vitamin D status with markers of metabolic health: A community-based study in Shanghai, China

“…There is some inconsistency in the literature, however [20][21][22]. Jorde et al [20], reported serum TC and LDL-C increased, instead of decreased, across quartiles of serum 25(OH)D concentration (i.e., from the lowest to the highest quartiles), which contradicts the findings of our study, although they did find a decrease in TG and increase in HDL across the serum 25(OH)D quartiles.…”

Body Mass Index, Vitamin D, and Type 2 Diabetes: A Systematic Review and Meta-Analysis

“…Sixteen studies [ 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ] were excluded as the data were not harmonious to calculate the effect size in the form of correlation. Five studies [ 87 , 88 , 89 , 90 , 91 ] were disqualified because of their study design, which was not well-suited with the study in progress.…”