The application of a supercritical antisolvent process for sustained drug delivery

Wang, Yulu; Wang, Yiping; Yang, Jun; Pfeffer, Robert; Davé, Rajesh N.; Michniak, B. B.

doi:10.1016/j.powtec.2006.03.004

Cited by 63 publications

(40 citation statements)

References 23 publications

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“…Due to precipitation of the polymer from the sprayed suspension, drug nanoparticles are entrapped by the polymer with a matrix or core-shell structure. 19,22 In order to strengthen mutual diffusion between the sprayed solution and the supercritical CO 2 , a solutionenhanced dispersion by supercritical fluid (SEDS) process was developed and has been widely used in supercritical fluid techniques. 23 During this process, the substrate(s) solution and supercritical CO 2 are copulverized through a coaxial nozzle, in which supercritical CO 2 acts as an antisolvent and spraying enhancer.…”

Section: Introductionmentioning

confidence: 99%

Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

Chen¹,

Wang²,

Wang³

et al. 2012

IJN

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Background:The aim of this study was to improve the drug loading, encapsulation efficiency, and sustained-release properties of supercritical CO 2 -based drug-loaded polymer carriers via a process of suspension-enhanced dispersion by supercritical CO 2 (SpEDS), which is an advanced version of solution-enhanced dispersion by supercritical CO 2 (SEDS). Methods: Methotrexate nanoparticles were successfully microencapsulated into poly (L-lactide)-poly(ethylene glycol)-poly(L-lactide) (PLLA-PEG-PLLA) by SpEDS. Methotrexate nanoparticles were first prepared by SEDS, then suspended in PLLA-PEG-PLLA solution, and finally microencapsulated into PLLA-PEG-PLLA via SpEDS, where an "injector" was utilized in the suspension delivery system. Results: After microencapsulation, the composite methotrexate (MTX)-PLLA-PEG-PLLA microspheres obtained had a mean particle size of 545 nm, drug loading of 13.7%, and an encapsulation efficiency of 39.2%. After an initial burst release, with around 65% of the total methotrexate being released in the first 3 hours, the MTX-PLLA-PEG-PLLA microspheres released methotrexate in a sustained manner, with 85% of the total methotrexate dose released within 23 hours and nearly 100% within 144 hours. Conclusion: Compared with a parallel study of the coprecipitation process, microencapsulation using SpEDS offered greater potential to manufacture drug-loaded polymer microspheres for a drug delivery system.

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Section: Introductionmentioning

confidence: 99%

Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

Chen¹,

Wang²,

Wang³

et al. 2012

IJN

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“…It is also used on other crops, such as vines, tomatoes, potatoes, pomes, other fruit and a wide variety of other crops. SFE has been used to obtain extracts with antioxidant activity from microalgae; by using the combination of SFE and HPLC with both DAD ESIMS) (Wang et al, 2006). The extraction can be selective to some extent by controlling the density of the medium and the extracted material is easily recovered by simply depressurizing, allowing the supercritical fluid to return to gas phase and evaporate leaving no or little solvent residues.…”

Section: Fig 1: Fenvaleratementioning

confidence: 99%

Validated High Performance Liquid Chromatographic Method for Analysis of Fenvalerate Pesticide in Chilies by QuEChERS Extraction Cleanup and High Liquid Chromatography

Ambarak¹

2010

American Journal of Applied Sciences

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Problem statement: Contamination associated with pesticide use has increased as well, adversely impacting the environment and causing human health risks through residues on food. Approach: This study reports the extraction of Fenvalerate (FE) in chilies using QuEChERS based on High Performance Liquid Chromatography (HPLC) describes a simple, fast and inexpensive method. The chillie was extracted with acetonitrile Aliquots were cleaned-up using Solid Phase Extraction (dSPE), a primary-secondary amine carbon black. Reversed-phased HPLC system with PDA detection was used for the separation identification and quantification of all these analyses using acetonitrile methanol-potassium dehydrogenate phosphate (50:40:10) as mobile phase. Results: Limit of detection of 0.01 µg mL was obtained. Calibration curves that constructed for the analyzes spiked into samples followed linear relationships with good correlation coefficients (R 2 >0.9944). In this method was found to be precise, specific and accurate for detection and analysis of Fenvalerate in chilies. Conclusion: QuEChERS methods are convenient, rugged methods that simplify extract cleanup, reduce material costs and improve sample throughout. Here we demonstrate the effectiveness of QuEChERS sample cleanup using a multiresidue analysis of pesticide on chilies.

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“…In order to preserve the activity of such ingredients and to prevent changes in the chemical composition of the functional compounds and/or mixture of compounds, sample preparation techniques based on the use of compressed fluids have been widely developed. SFE has been used to obtain extracts with antioxidant activity from microalgae; by using the combination of SFE and HPLC with both DAD ESI-MS [13] . Several functional compounds were identified corresponding to different carotenoids along with chlorophyll a and some chlorophyll degradation products.…”

Section: Encapsulation Of Liquids For Engineering Solid Productsmentioning

confidence: 99%

A Review on Supercritical Fluid Extraction as New Analytical Method

Abbas¹,

Mohamed²,

Abdulamir³

et al. 2008

American J. of Biochemistry and Biotechnology

100

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This review study summarized the Supercritical Fluid Extraction (SFE) as new analytical method. The advantage and disadvantage of CO 2 (SC-CO 2 )as well as special applications of SFE in food processing such as removal of fat from food, enrichment of vitamin E from natural sources, removal of alcohol from wine and beer, encapsulation of liquids for engineering solid products and extraction and characterization of functional compounds were also highlighted. The study also covered the application of SFE in food safety such as rapid analysis for fat content, rapid analysis for pesticides in foods as well as the recent applications of SFE in food such as supercritical particle formation and nan particle formation and ssupercritical drying. The outcome finding confirmed that SFE was found to be advance, fast, reliable, clean and cheap methods for routine food analysis.

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The application of a supercritical antisolvent process for sustained drug delivery

Cited by 63 publications

References 23 publications

Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

Validated High Performance Liquid Chromatographic Method for Analysis of Fenvalerate Pesticide in Chilies by QuEChERS Extraction Cleanup and High Liquid Chromatography

A Review on Supercritical Fluid Extraction as New Analytical Method

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