An interacting multi-agent system in a network can model the evolution of a Nature-Inspired Smart System (NISS) exhibiting the four salient properties: (i) Collective, coordinated and efficient (ii) Self-organization and emergence (iii) Power law scaling or scale invariance under emergence (iv) Adaptive, fault tolerant and resilient against damage. We explain how these basic properties can arise among agents through random enabling, inhibiting, preferential attachment and growth of a multiagent system. The quantitative understanding of a Smart system with an arbitrary interactive topology is extremely difficult. However, for specific applications and a predefined static interactive topology among the agents, the quantitative parameters can be obtained through simulation to build a specific NISS. Further developments of agent technology will be of great value to model, simulate and animate, many phenomena in Systems biology-pattern formation, cellular dynamics, cell motility, growth and development biology, and can provide for improved capability in complex systems modelling. Also agents will serve as useful tools to model, design and develop biomorphic robots and neuromorphic chips.