The application of antimicrobial photodynamic therapy (aPDT, 670 nm) and diode laser (940 nm) as adjunctive approach in the conventional cause-related treatment of chronic periodontal disease: a randomized controlled split-mouth clinical trial

Katsikanis, Fotios; Strakas, Dimitrios; Vouros, Ioannis

doi:10.1007/s00784-019-03045-1

Cited by 45 publications

(40 citation statements)

References 21 publications

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“…These articles were evaluated based on the eligibility criteria of the review. Additional studies were excluded due to the following reasons: an inappropriate study design or article type in 9 studies (15,16,21–27), LLLT utilized, as an adjunct to a surgical intervention or in the supportive periodontal therapy phase in 3 studies (28–30), in vitro or in vivo animal studies utilized in 3 papers (31–33), participants with systemic diseases recruited in 3 studies (34–39), no utilization of PBM in 11 studies (40–50), and LLLT utilized either; as a mono‐therapeutic agent or in combination with aPDT in 3 studies (51–53) (inter‐reviewer agreement, κ = 1). Hence, out of 52 full text articles, 35 articles were excluded, due to the abovementioned reasons, while the remaining 17 articles were included and analyzed in the present systematic review.…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of Photobiomodulation as an Adjunct to Nonsurgical Periodontal Therapy in the Management of Periodontitis‐ A Systematic Review of in vivo Human Studies

Dalvi

Benedicenti

Hanna

2020

Photochem & Photobiology

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Photobiomodulation therapy (PBMT) has anti‐inflammatory, analgesic and regenerative properties. This systematic review aimed to critically appraise the published data of in vivo human randomized clinical trials (RCTs), and present a comprehensive overview of the efficacy of PBMT, as an adjunct to the nonsurgical periodontal therapy (NSPT) in the management of periodontitis. The systematic review protocol is registered in the Prospective Register Of Systematic Reviews (PROSPERO) (http://www.crd.york.ac.uk/PROSPERO/; ref CRD 42020169108). With the help of the appropriate key words, structured electronic and manual search strategies were applied to gather the relevant published data on in vivo human RCTs based on this topic. Seventeen papers that met the eligibility criteria were included in this review and subjected to a qualitative assessment. Current evidence lacks adequate information regarding the photobiomodulation (PBM) dosimetry, which is fundamental in establishing a standardized and replicable protocol for future researches. Furthermore, substantial discrepancies in the study methodology and a high risk of bias, arising from the majority of the included papers, abet to the inferior quality of these studies. Ultimately, there is an urgent necessity to conduct further well‐designed RCTs in order to determine the effectiveness of PBMT, if any, by taking into consideration the abovementioned confounding factors.

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Section: Resultsmentioning

confidence: 99%

Effectiveness of Photobiomodulation as an Adjunct to Nonsurgical Periodontal Therapy in the Management of Periodontitis‐ A Systematic Review of in vivo Human Studies

Dalvi

Benedicenti

Hanna

2020

Photochem & Photobiology

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“…[ 33 ] 940 nm has shown better efficacy and safety than other wavelengths in one of the studies. [ 44 ] In another study by Katsikanis et al, [ 65 ] significant pocket depth reduction was evident after a period of 3 months.…”

Section: Discussionmentioning

confidence: 99%

Applications of lasers in refractory periodontitis: A narrative review

Varma

AlShayeb

Narayanan

et al. 2020

J Int Soc Prevent Communit Dent

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A BSTRACT Objective: The purpose of the study is to evaluate the various lasers in dentistry and to investigate if it can be used for treatment of refractory periodontitis. Methods: The study followed partially the PRISMA guidelines as it is a narrative review. A number of articles were selected from a period of 1980 to 2020 from databases, PubMed, PubMed central, Cochrane and Scopus. Articles related to the effects of lasers on periodontitis both refractory and aggressive were investigated. Results: After reviewing the literature, 70 articles were found, related to application of lasers in periodontal diseases. Out of the 70, 11 articles pertained to the effect of laser for the treatment of Refractory and inflammatory periodontitis. 5 articles related to experimental animal models, one pertaining to in-vitro and six studies related to in-vivo in human cohorts. Discussion: It was found that lasers if used in controlled parameters by incorporating laser assisted treatment such as Photodynamic therapy and low level laser therapy can be of use as an adjunct therapy for treatment of refractory periodontitis. The use of different wavelengths in the initial and maintenance phase of periodontal disease plays a positive role. The presence of in-vitro and animal model studies is one of the limitation to this study. The available studies have shown marked reduction in inflammation and better clinical and microbiological parameters. The drawback of this study is the limited literature involving laser management for refractory periodontitis in human cohorts. Conclusion: Different wavelengths of laser and choice of laser assisted periodontal treatment plays an important role in the overall progress and prognosis of periodontal disease activity.

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“…Nine parallel [39][40][41][42][43][44][45][46][47] and seven split-mouth [48][49][50][51][52][53][54] design trials were included with a total of 652 participants, within an age range between 20 and 82 years (Table 1). All of the studies were reported in English and conducted in fourteen countries from four continents.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The selected studies were published as journal articles between 1999 and 2021, with the exception of a master's thesis [45]. The duration of the included studies ranged between 6 months and 36 months, and 62.5% of the studies had less than 12 months follow-up [45][46][47][48][49][50][51][52][53][54]. Most trials were conducted in a university setting, except for two that involved private practices [44,50].…”

Section: Study Characteristicsmentioning

confidence: 99%

Clinical Efficacy of Repeated Applications of Local Drug Delivery and Adjunctive Agents in Nonsurgical Periodontal Therapy: A Systematic Review

2021

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The aim of this systematic review is to compare the clinical efficacy of repeated applications of local drug delivery and adjunctive agents (LDAs) in nonsurgical periodontal therapy (NSPT) compared to subgingival mechanical debridement (SMD) alone. The Cochrane Central Register of Controlled Trials, MEDLINE, PubMed, EMBASE, Web of Science, hand-searched literature and grey literature databases were searched for randomized controlled clinical trials (RCTs) with a minimum of 6-month follow-up. The outcomes of interest were changes in probing pocket depth and clinical attachment level as well as patient-centred outcomes. Of 1094 studies identified, 16 RCTs were included in the qualitative analysis. Across 11 different adjuncts analysed, only two studies utilizing minocycline gel/ointment and antimicrobial photodynamic therapy (aPDT) with indocyanine green photosensitizer had statistically significant differences in primary outcomes when compared to their control groups. Only one study on aPDT methylene blue 0.005% had compared single versus multiple applications against its control group. A mean range of 0.27–3.82 mm PD reduction and −0.09–2.82 mm CAL gain were observed with repeated LDA application. Considerable clinical heterogeneity and methodological flaws in the included studies preclude any definitive conclusions regarding the clinical efficacy of repeated LDA applications. Future RCTs with a direct comparison between single and repeated applications should be conducted to confirm or refute the clinical advantages of repeated LDA application in the nonsurgical management of periodontitis.

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The application of antimicrobial photodynamic therapy (aPDT, 670 nm) and diode laser (940 nm) as adjunctive approach in the conventional cause-related treatment of chronic periodontal disease: a randomized controlled split-mouth clinical trial

Cited by 45 publications

References 21 publications

Effectiveness of Photobiomodulation as an Adjunct to Nonsurgical Periodontal Therapy in the Management of Periodontitis‐ A Systematic Review of in vivo Human Studies

Effectiveness of Photobiomodulation as an Adjunct to Nonsurgical Periodontal Therapy in the Management of Periodontitis‐ A Systematic Review of in vivo Human Studies

Applications of lasers in refractory periodontitis: A narrative review

Clinical Efficacy of Repeated Applications of Local Drug Delivery and Adjunctive Agents in Nonsurgical Periodontal Therapy: A Systematic Review

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