The Application of Bactericidal Silver Nanoparticles in Wound Treatment

Abstract

Even with the prevalence of wounds, the medical technology for efficiently managing skin damage is still primitive. The disruption of any of the numerous healing processes can lead to problems in the time-sensitive healing actions of the dermal and epidermal layers. Bacterial infection is one of the major obstacles to proper wound healing as it poses a danger of causing long-term negative effects. Keeping the wound free of bacteria is imperative to the proper and hasty repair of dermal wounds. Silver has been widely used to treat wounds for its bactericidal properties. Although the mechanism of silver's antibacterial action is not fully understood, it exhibits a significant antimicrobial efficacy against a wide spectrum of bacterial species. A number of different approaches to the mechanism are reported and presented in this review. Silver nanoparticles (AgNPs) have been reported to exhibit enhanced antibacterial activity due to their increased surface-area-to-volume ratio. AgNPs are capable of various modifications, significantly broadening the therapeutic properties of the material as a result. This review explores the different aspects of silver and silver nanoparticles, and their antibacterial properties, which can be applied in the field of wound treatments.

Response of Human Macrophages to Clinically Applied Wound Dressings Loaded With Silver

“…In particular, antibiotic-free antibacterial wound dressings are on the rise, in accordance with the constantly increasing number of bacterial species isolated from non-healing wounds that are resistant to commonly used antibiotics in the hospital setting (Piddock, 2017). Among the available products, silverbased wound dressings definitely dominate the market, due to silver's broad antimicrobial activity against more than 600 clinically isolated strains of non-and more importantly drugresistant bacteria (Nam et al, 2015;Zewde et al, 2016;Simões et al, 2018). Generally, the antimicrobial principle of these silver dressings relies on the release of silver ions (Ag + ) that induce the antimicrobial activity.…”

Leveraging the Attributes of Mucor hiemalis-Derived Silver Nanoparticles for a Synergistic Broad-Spectrum Antimicrobial Platform

“…Bacteria residing in biofilms are observed to be significantly more resistant to antibacterial compounds with respect to their planktonic form and therefore the ability of AgNPs to interfere with bacterial biofilms affords a key opportunity for biomedical applications. The most notable application of AgNPs in the medical industry include topical ointments (Tian et al, 2007; Hebeisha et al, 2014), while newly devised AgNPs-coated dressings also appear promising for the management of wounds and infections (Maneerung et al, 2008; Wilkinson et al, 2011; Nam et al, 2015). …”

In vitro and in vivo evaluation of biologically synthesized silver nanoparticles for topical applications: effect of surface coating and loading into hydrogels

“…74 MRSA is the main cause of worldwide nosocomial infections and usually causes superficial lesions in human skin, localized abscesses, septicemia, pneumonia, and bacteremia. 8 The antibacterial activity of the biologically synthesized 0.1% 10 mM PEG-coated-AgNPs-loaded Na CMC hydrogel (F3) against MRSA-infected skin model was tested in mice.…”