The Application of Chemometrics for Efficiency Enhancement and Toxicity Reduction in Cancer Treatment with Combined Therapy

Qian, Ke; Yan, Binjun; Xiong, Yang

doi:10.2174/1567201817999200817152235

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…In as much as monotherapy treatment is often used to treat cancers, combinatorial treatments targeting specific cell-sustaining and cancer-inducing pathways are the mainstays and most efficient. 55 , 56 Traditional chemo-based monotherapy treatments usually damage cancerous and healthy cells since chemotherapy targets all proliferating cells. Also, conventional monotherapeutic techniques can be highly toxic and significantly compromise patients’ immune systems, increasing their disease susceptibility.…”

Section: Cancermentioning

confidence: 99%

Multifunctional nanoparticle-mediated combining therapy for human diseases

Li,

Peng,

Zoulikha

et al. 2024

Sig Transduct Target Ther

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Combining existing drug therapy is essential in developing new therapeutic agents in disease prevention and treatment. In preclinical investigations, combined effect of certain known drugs has been well established in treating extensive human diseases. Attributed to synergistic effects by targeting various disease pathways and advantages, such as reduced administration dose, decreased toxicity, and alleviated drug resistance, combinatorial treatment is now being pursued by delivering therapeutic agents to combat major clinical illnesses, such as cancer, atherosclerosis, pulmonary hypertension, myocarditis, rheumatoid arthritis, inflammatory bowel disease, metabolic disorders and neurodegenerative diseases. Combinatorial therapy involves combining or co-delivering two or more drugs for treating a specific disease. Nanoparticle (NP)-mediated drug delivery systems, i.e., liposomal NPs, polymeric NPs and nanocrystals, are of great interest in combinatorial therapy for a wide range of disorders due to targeted drug delivery, extended drug release, and higher drug stability to avoid rapid clearance at infected areas. This review summarizes various targets of diseases, preclinical or clinically approved drug combinations and the development of multifunctional NPs for combining therapy and emphasizes combinatorial therapeutic strategies based on drug delivery for treating severe clinical diseases. Ultimately, we discuss the challenging of developing NP-codelivery and translation and provide potential approaches to address the limitations. This review offers a comprehensive overview for recent cutting-edge and challenging in developing NP-mediated combination therapy for human diseases.

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Section: Cancermentioning

confidence: 99%

Multifunctional nanoparticle-mediated combining therapy for human diseases

Li,

Peng,

Zoulikha

et al. 2024

Sig Transduct Target Ther

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show abstract

“…Single agent-based strategies are often insufficient for a successful and complete tumor eradication in cancer patients. Current strategies aim at combining therapies with a second (or even third) drug to amplify anti-tumor responses and/or to broaden the spectrum of responding patients (Bao et al, 2020;Crunkhorn, 2020;GajdÁcs et al, 2020;Iratni and Ayoub, 2020;Jonnalagadda et al, 2020;Karimi et al, 2020;Kawachi et al, 2020;Kim et al, 2020;Mollica et al, 2020;Qian et al, 2020;Song et al, 2020;Yamashita et al, 2020;Zhu et al, 2020). The development of microfluidic devices for oncoimmunology applications based on the use of drug combinations is only beginning to emerge.…”

Section: Ooc Applications For the Evaluation Of Anticancer Drug Combimentioning

confidence: 99%

Oncoimmunology Meets Organs-on-Chip

Mattei

Andreone

Mencattini

et al. 2021

Front. Mol. Biosci.

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Oncoimmunology represents a biomedical research discipline coined to study the roles of immune system in cancer progression with the aim of discovering novel strategies to arm it against the malignancy. Infiltration of immune cells within the tumor microenvironment is an early event that results in the establishment of a dynamic cross-talk. Here, immune cells sense antigenic cues to mount a specific anti-tumor response while cancer cells emanate inhibitory signals to dampen it. Animals models have led to giant steps in this research context, and several tools to investigate the effect of immune infiltration in the tumor microenvironment are currently available. However, the use of animals represents a challenge due to ethical issues and long duration of experiments. Organs-on-chip are innovative tools not only to study how cells derived from different organs interact with each other, but also to investigate on the crosstalk between immune cells and different types of cancer cells. In this review, we describe the state-of-the-art of microfluidics and the impact of OOC in the field of oncoimmunology underlining the importance of this system in the advancements on the complexity of tumor microenvironment.

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The Application of Chemometrics for Efficiency Enhancement and Toxicity Reduction in Cancer Treatment with Combined Therapy

Cited by 2 publications

References 22 publications

Multifunctional nanoparticle-mediated combining therapy for human diseases

Multifunctional nanoparticle-mediated combining therapy for human diseases

Oncoimmunology Meets Organs-on-Chip

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