The application of collagen in the repair of peripheral nerve defect

Li, Xiaolan; Zhang, Xiang; Hao, Ming; Wang, Dongxu; Jiang, Ziping; Sun, Liqun; Gao, Yongjian; Ye, Jin; Peng, Lei; Yang, Zhuo

doi:10.3389/fbioe.2022.973301

Cited by 16 publications

(18 citation statements)

References 216 publications

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“…As one of the most important components of the ECM 31 , Col is undoubtedly the most frequently used natural protein in the nervous system 32,33 , and is widely used as a biological scaffold for nerve regeneration [34][35][36] . It is shown that Col could help nerve regeneration with/without growth factors [37][38][39][40][41][42] .…”

Section: Extracellular Matrixmentioning

confidence: 99%

Transcriptome analysis of Long non-coding RNAs altered in sciatic nerves of aging SD rats

Kuang

Zhang

et al. 2023

Preprint

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Objectives To investigate the long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) changes in the sciatic nerve (SN) in Sprague Dawley (SD) rats during aging. Methods Eighteen healthy SD rats were selected at the age of 1 month (1M) and 24 months (24M) and SNs were collected. High-throughput transcriptome sequencing and bioinformatics analysis were performed. Protein-protein interaction (PPI) networks and competing endogenous RNA (ceRNA) networks were established according to differentially expressed genes (DEGs). Result As length of lncRNAs increased, its proportion to the total number of lncRNAs decreased. A total of 4079 DElncRNAs were identified in Con vs 24M. GO analysis were primarily clustered in nerve and lipid metabolism, extracellular matrix, and vascularization related fields. There were 17 nodes in the PPI network of the target genes of up-regulating genes including Itgb2, Lox, Col11a1, Wnt5a, Kras, etc. Using quantitative RT-PCR, microarray sequencing accuracy was validated. And there were 169 nodes constructing the PPI network of down-regulated target genes, mainly including Col1a1, Hmgcs1, Hmgcr. CeRNA interaction networks were constructed. Conclusion Lipid metabolism, angiogenesis and ECM fields might play an important role in senescence process in SNs. Col3a1, Serpinh1, Hmgcr, Fdps could be candidates for nerve aging research.

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Section: Extracellular Matrixmentioning

confidence: 99%

Transcriptome analysis of Long non-coding RNAs altered in sciatic nerves of aging SD rats

Kuang

Zhang

et al. 2023

Preprint

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“…Cross-linking strategies have been developed in an effort to improve their mechanical strength and stability. Collagen has been a popular choice, as it is readily available, has low immunological properties, good biocompatibility, a porous structure, and is biodegradable [12].…”

Section: Nerve Guide Conduitsmentioning

confidence: 99%

Nerve guide conduits, nerve transfers, and local and free muscle transfer in facial nerve palsy

Shoman

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of review To highlight the recent literature on reinnervation options in the management of facial nerve paralysis using nerve conduits, and nerve and muscle transfers. Recent findings Engineering of natural and synthetic nerve conduits has progressed and many of these products are now available on the market. The use of the masseter nerve has become more popular recently as a choice in nerve transfer procedures due to various unique advantages. Various authors have recently described mimetic muscle reinnervation using more than one nerve transfer, as well as dual and triple innervation of free muscle transfer. Summary The ideal nerve conduit continues to be elusive, however significant progress has been made with many natural and synthetic materials and designs tested and introduced on the market. Many authors have modified the classic approaches in motor nerve transfer, as well as local and free muscle transfer, and described new ones, that aim to combine their advantages, particularly the simplification to a single stage and use of multiple reinnervation to the mimetic muscles. These advances are valuable to the reconstructive surgeon as powerful tools that can be tailored to the unique challenges of patients with facial nerve palsy looking for dynamic reanimation options.

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“…Growth factor analogs, such as bFGF and VEGF, play crucial roles in wound healing, tissue regeneration, angiogenesis, and nerve regeneration. [407][408][409] As previously mentioned, the short half-life and rapid diffusion of exogenous growth factors in body fluids result in decreased utilization efficiency, often necessitating high doses or repeated applications to achieve therapeutic effects. 410,411 Capitalizing on the benefits of collagen, we have employed it to encapsulate growth factors and facilitate targeted transport to wound areas, thereby enhancing the woundhealing process, which is closely tied to vascular and nerve regeneration.…”

Section: Collagen Scaffolds Loaded With Therapeutic Factormentioning

confidence: 99%

“…Growth factor analogs, such as bFGF and VEGF, play crucial roles in wound healing, tissue regeneration, angiogenesis, and nerve regeneration 407–409 . As previously mentioned, the short half‐life and rapid diffusion of exogenous growth factors in body fluids result in decreased utilization efficiency, often necessitating high doses or repeated applications to achieve therapeutic effects 410,411 .…”

Section: The Future Of Regenerative Medicine In Cyclical Endometrial ...mentioning

confidence: 99%

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

Hu,

Wu,

Yong

et al. 2023

MedComm

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The endometrium is a unique human tissue with an extraordinary ability to undergo a hormone‐regulated cycle encompassing shedding, bleeding, scarless repair, and regeneration throughout the female reproductive cycle. The cyclical repair and regeneration of the endometrium manifest as changes in endometrial epithelialization, glandular regeneration, and vascularization. The mechanisms encompass inflammation, coagulation, and fibrinolytic system balance. However, specific conditions such as endometriosis or TCRA treatment can disrupt the process of cyclical endometrial repair and regeneration. There is uncertainty about traditional clinical treatments' efficacy and side effects, and finding new therapeutic interventions is essential. Researchers have made substantial progress in the perspective of regenerative medicine toward maintaining cyclical endometrial repair and regeneration in recent years. Such progress encompasses the integration of biomaterials, tissue‐engineered scaffolds, stem cell therapies, and 3D printing. This review analyzes the mechanisms, diseases, and interventions associated with cyclical endometrial repair and regeneration. The review discusses the advantages and disadvantages of the regenerative interventions currently employed in clinical practice. Additionally, it highlights the significant advantages of regenerative medicine in this domain. Finally, we review stem cells and biologics among the available interventions in regenerative medicine, providing insights into future therapeutic strategies.

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The application of collagen in the repair of peripheral nerve defect

Cited by 16 publications

References 216 publications

Transcriptome analysis of Long non-coding RNAs altered in sciatic nerves of aging SD rats

Transcriptome analysis of Long non-coding RNAs altered in sciatic nerves of aging SD rats

Nerve guide conduits, nerve transfers, and local and free muscle transfer in facial nerve palsy

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

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