2021
DOI: 10.1159/000518052
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The Application of DNA Ploidy Analysis in Large-Scale Population Screening for Cervical Cancer

Abstract: <b><i>Objective:</i></b> The objective of this study was to evaluate the application of DNA ploidy analysis in large-scale population screening for cervical cancer. <b><i>Methods:</i></b> From March 2016 to March 2019, eligible subjects were enrolled and recommended to undergo DNA ploidy analysis, the ThinPrep cytology test (TCT), and high-risk human papillomavirus (hrHPV) detection concurrently. Patients with positive results were recommended for colposcopy, and… Show more

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Cited by 5 publications
(2 citation statements)
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“…Automatic cell DNA quantitative analysis system allows the detection of DNA ploidy of genetic material in the nucleus, the investigation of the physiological state and pathological cell changes and allows the evaluation of cancer and precancerous lesions. The system can be used to analyze a variety of gynecological and non-gynecological clinical cytological specimens, including cervical exfoliation specimens, and can also assist the assessment of healing after tumor treatment (82).…”
Section: Auxiliary Diagnosticmentioning
confidence: 99%
“…Automatic cell DNA quantitative analysis system allows the detection of DNA ploidy of genetic material in the nucleus, the investigation of the physiological state and pathological cell changes and allows the evaluation of cancer and precancerous lesions. The system can be used to analyze a variety of gynecological and non-gynecological clinical cytological specimens, including cervical exfoliation specimens, and can also assist the assessment of healing after tumor treatment (82).…”
Section: Auxiliary Diagnosticmentioning
confidence: 99%
“…Alternatively, DNA ploidy analysis and TrueScreen can be performed for the detection of cervical hyperplasia and dysplasia. These methods are preferred due to their low cost, non-dependence on cytopathologists, and they can be applied in a large-scale population screening [ 45 ]. DNA ploidy analysis is performed to assess the physiological state and the pathological changes of cells by measuring the DNA content or chromosome multiplication in the nucleus.…”
Section: Detection Of Premalignancy and Malignancy Of The Uterine Cervixmentioning
confidence: 99%