The Application of Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography in Macular Diseases

Wang, Jing; Yin, Lian-Rong

doi:10.1155/2020/9503795

Cited by 10 publications

(9 citation statements)

References 67 publications

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“…Compared with traditional OCT (used for years), this imaging modality can display choroidal structure, scleral canal, and to some extent the optic nerve more clearly. Application in macular studies is discussed by Wang et al [ 16 ]. Three anatomical structures have been identified on EDI-OCT of the optic nerve head: Optic disc drusen (ODD), prelaminar hyperreflective lines (HL), and peripapillary hyper-reflective ovoid mass-like structures (PHOMS).…”

Section: Introductionmentioning

confidence: 99%

OCT Based Interpretation of the Optic Nerve Head Anatomy and Prevalence of Optic Disc Drusen in Patients with Idiopathic Intracranial Hypertension (IIH)

Wibroe

Malmqvist

Hamann

2021

Life

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We aimed to systematically examine the optic nerve head anatomy in patients with idiopathic intracranial hypertension (IIH) using a standardized optical coherence tomography (OCT) protocol. The study retrospectively included 32 patients diagnosed from 2014 to 2021 with IIH. Using OCT, in accordance with a standardized scanning protocol for patients with optic disc drusen, the presence of optic disc drusen, prelaminar hyperreflective lines, peripapillary hyperreflective ovoid mass-like structures, the retinal nerve fiber layer thickness, and macular ganglion cell layer volume was obtained. Optic disc drusen were found in 3.1%, hyperreflective lines in 31.3%, and peripapillary hyperreflective ovoid mass-like structures in 81.3% of all IIH patients at least three months after the time of diagnosis. We found no significant differences in retinal nerve fiber layer thickness or macular ganglion cell layer volume in patients with hyperreflective lines or PHOMS respectively compared to patients without hyperreflective lines (p = 0.1285 and p = 0.1835). In conclusion, the prevalence of optic disc drusen in IIH patients is similar to the reported prevalence in the general population. The high prevalence of hyperreflective lines and peripapillary hyperreflective ovoid mass-like structures in IIH patients suggest these structures be a result of crowding in the optic nerve head caused by papilledema.

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Section: Introductionmentioning

confidence: 99%

OCT Based Interpretation of the Optic Nerve Head Anatomy and Prevalence of Optic Disc Drusen in Patients with Idiopathic Intracranial Hypertension (IIH)

Wibroe

Malmqvist

Hamann

2021

Life

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“…OCT images provide detailed information about the layers of the retina. Optical coherence tomography (SD-OCT) is often used to improve retinal assessment measures [27]. e image affected by glaucoma has a larger cup diameter than the normal OCT image, as presented in Figure 4.…”

Section: Optical Coherence Tomography (Oct) Image Analysismentioning

confidence: 99%

A Comprehensive Convolutional Neural Network Survey to Detect Glaucoma Disease

Zafar

Aamir

Nawi

et al. 2022

Mobile Information Systems

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Due to recent advances in computer technology and the accessibility of large datasets, deep learning has become at the forefront of artificial intelligence and on various tasks, especially those related to image classification and modelling, its performance is often equal to or even better than human appreciation. Ophthalmology has always been in an ideal position to employ one of CNN’s most popular deep learning algorithms to evaluate vast volumes of data from these tests since it is one of the health practices that focuses extensively on imaging. Glaucoma is one among the situations in which CNN can benefit from the enormous quantity of data collected by tests that assess the anatomy as well as function of the optic nerve and macula. We discussed the recommended use of CNN algorithm for specific glaucoma scenarios, such as fundus photography screening and diagnosis and detection of the course of glaucoma through OCT imaging modality. The purpose of this article is not only to critically examine and discuss the latest applications of CNN models in glaucoma but also to focus on the challenges associated with developing such models for screening, diagnosis, and progress detection. After a brief overview of the clinical practices and their comparison with conventional clinical methods, we discussed training and validation of CNN algorithm and how it was developed and why it is particularly suitable for glaucoma. The following features make our contribution worthwhile and unique among the reviews of similar kind: (i) our review classifies the existing literature with respect to detection of the glaucoma disease using conventional and nonconventional approaches; (ii) it covers a very different outlook of the glaucoma disease by providing in-depth discussions of the existing works at different granularity levels, that is, from primary to mediatory to the severe level; (iii) this state-of-the-art review covers each article in the following dimensions: the computer-based approach to tomographic model; analysis of different datasets; and summarizing the literature review in a disciplined way by mentioning the research gap concluded with discussion on future work.

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“…e evaluation of morphological parameters of the choroid has been enhanced with the latest Swept Source OCTs enabling the analysis beyond the RPE through a strong signal identifying the vascular layer boundaries [114]. e reproducibility of the measurement is still uncertain, probably due to the circadian variation of choroidal thickness, its sensibility to systemic pressure, and different ocular variables like pre-and post-anti-VEGF injection conditions [115].…”

Section: Choroidal Ickness: Subfoveal Choroidal Ickness and Choroidal Volumementioning

confidence: 99%

“…All choroidal parameters, in particular the widely studied subfoveal choroidal thickness (Figure 10), did not demonstrate a correlation with visual acuity recovery in treated patients, nor a different response to intravitreal anti-VEGF therapy. Choroidal volume, trying to avoid biases in choroidal boundary measurements, still does not show interesting clinical correlations [114,117,118].…”

Section: Choroidal Ickness: Subfoveal Choroidal Ickness and Choroidal Volumementioning

confidence: 99%

OCT Biomarkers in Neovascular Age-Related Macular Degeneration: A Narrative Review

Metrangolo

Donati

Mazzola

et al. 2021

Journal of Ophthalmology

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Age-related macular degeneration (AMD) is the leading cause of legal blindness in elderly people. Neovascular AMD (nAMD) is responsible for the majority of cases of severe visual loss in eyes with AMD. Optical coherence tomography (OCT) is the most widely used technology for the diagnosis and follow-up of nAMD patients, which is widely used to study and guide the clinical approach, as well as to predict and evaluate treatment response. The aim of this review is to describe and analyze various structural OCT-based biomarkers, which have practical value during both initial assessment and treatment follow-up of nAMD patients. While central retinal thickness has been the most common and one of the first OCT identified biomarkers, today, other qualitative and quantitative biomarkers provide novel insight into disease activity and offer superior prognostic value and better guidance for tailored therapeutic management. The key importance of retinal fluid compartmentalization (intraretinal fluid, subretinal fluid, and subretinal pigment epithelium (RPE) fluid) will be discussed firstly. In the second part, the structural alterations of different retinal layers in various stages of the disease (photoreceptors layer integrity, hyperreflective dots, outer retinal tubulations, subretinal hyperreflective material, and retinal pigment epithelial tears) will be analyzed in detail. The last part of the review will focus on how alterations of the vitreoretinal interface (vitreomacular adhesion and traction) and of the choroid (sub-RPE hyperreflective columns, prechoroidal clefts, choroidal caverns, choroidal thickness and choroidal volume, and choroidal vascular index) interact with nAMD progression. OCT technology is evolving very quickly, and new retinal biomarkers are continuously described. This up-to-date review article provides a comprehensive description on how structural OCT-based biomarkers provide a valuable tool to monitor the progression of the disease and the treatment response in nAMD patients. Thus, in this perspective, clinicians will be able to allocate hospital resources in the best possible way and tailor treatment to the individual patient’s needs.

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The Application of Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography in Macular Diseases

Cited by 10 publications

References 67 publications

OCT Based Interpretation of the Optic Nerve Head Anatomy and Prevalence of Optic Disc Drusen in Patients with Idiopathic Intracranial Hypertension (IIH)

OCT Based Interpretation of the Optic Nerve Head Anatomy and Prevalence of Optic Disc Drusen in Patients with Idiopathic Intracranial Hypertension (IIH)

A Comprehensive Convolutional Neural Network Survey to Detect Glaucoma Disease

OCT Biomarkers in Neovascular Age-Related Macular Degeneration: A Narrative Review

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