The application of fibrin sealant for the prevention of lymphocele after lymphadenectomy in patients with gynecological malignancies: A systematic review and meta-analysis of randomized controlled trials

The effect of fibrin glue on the postoperative lymphatic drainage after gastrectomy and D2 dissection: a randomized clinical trial

“…These products are different regarding the source of brinogen, thrombin and aprotinin which could be of the human or bovine origin. Newer products contain human based compound, in order to lessen potential immunogenic reaction [25,26] or anaphylaxis caused by bovine aprotinin [27].…”

“…Another systematic review and meta-analysis of randomized controlled trials on application of brin sealant for the prevention of lymphocele after lymphadenectomy in patients with gynecological malignancies was performed by Prodromidou et al [27]. Four hundred eighty one patients from six randomized clinical trials were included and it was found that brin sealant could signi cantly decrease total amount of drained uid and mean duration of drainage.…”

Surgical Strategies for Lymphocele Prevention in Minimally Invasive Radical Prostatectomy and Lymph Node Dissection: A Systematic Review

“…Some of these agents have been investigated in order to assess their ability to prevent lymphocele formation with a mechanism thought to be due to the mechanical compression with a lymphostatic effect or a direct effect of the presence of coagulation cascade components in the lymphatic fluid. A meta-analysis of randomized controlled trials including patients who underwent lymph node dissection for gynecological malignancies found no differences in overall and symptomatic lymphocele rates in groups where fibrin collagen agents were used vs standard technique (OR 0.61 95% CI 0.36 to 1.05 p = 0.08 and OR 0.59 95% CI 0.26 to 1.35 p = 0.22, respectively) but showed a decreased duration and volume of lymphatic drainage [26]. Inguinal lymph node dissection is a procedure known by urologists for penile cancer but it is also performed for melanoma: in this setting a recent meta-6 Journal of Endourology Surgical strategies for lymphocele prevention in minimally-invasive radical prostatectomy and lymph-node dissection: a systematic review (DOI: 10.1089/end.2019.0716) This paper has been peer-reviewed and accepted for publication, but has yet to undergo copyediting and proof correction.…”

Topical haemostatics and sealants in gynaecological and obstetric surgery: state of the art

“…The application of fibrin-collagen coated patches in the area of lymphadenectomy has been proposed to prevent the formation of lymphocele after lymphadenectomy, similarly to what already experienced in cardiovascular, hepatic, pulmonary and kidney surgeries for haemostatic purposes. Nevertheless, results from studies conducted to evaluate the efficacy of this agents in prevention of lymphocele after lymph node dissection for cancer, are controversial [26,27].…”