The application of indocyanine green in guiding prostate cancer treatment

Xie, Da; Gu, Dawu; Lei, Ming; Cai, Cong; Zhang, Wen; Qi, Defeng; Wu, Weihong; Zeng, Guohua; Liu, Yongda

doi:10.1016/j.ajur.2021.07.004

Cited by 6 publications

(2 citation statements)

References 49 publications

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“…An effective substitute for assessing lymphatics is near-infrared fluorescence imaging, which uses a contrast media injected intradermally instead of a radionuclide to access the primary lymphatics beneath the epidermis, helping to assess lymphatic anatomy and function [38] (Figure 2). The main benefit consists of the acquisition of real-time images.…”

Section: Near-infrared Fluorescence Imagingmentioning

confidence: 99%

Diagnosis and Treatment of Post-Prostatectomy Lymphedema: What’s New?

et al. 2023

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Lymphedema is a chronic progressive disorder that significantly compromises patients’ quality of life. In Western countries, it often results from cancer treatment, as in the case of post-radical prostatectomy lymphedema, where it can affect up to 20% of patients, with a significant disease burden. Traditionally, diagnosis, assessment of severity, and management of disease have relied on clinical assessment. In this landscape, physical and conservative treatments, including bandages and lymphatic drainage have shown limited results. Recent advances in imaging technology are revolutionizing the approach to this disorder: magnetic resonance imaging has shown satisfactory results in differential diagnosis, quantitative classification of severity, and most appropriate treatment planning. Further innovations in microsurgical techniques, based on the use of indocyanine green to map lymphatic vessels during surgery, have improved the efficacy of secondary LE treatment and led to the development of new surgical approaches. Physiologic surgical interventions, including lymphovenous anastomosis (LVA) and vascularized lymph node transplant (VLNT), are going to face widespread diffusion. A combined approach to microsurgical treatment provides the best results: LVA is effective in promoting lymphatic drainage, bridging VLNT delayed lymphangiogenic and immunological effects in the lymphatic impairment site. Simultaneous VLNT and LVA are safe and effective for patients with both early and advanced stages of post-prostatectomy LE. A new perspective is now represented by the combination of microsurgical treatments with the positioning of nano fibrillar collagen scaffolds (BioBridgeTM) to favor restoring the lymphatic function, allowing for improved and sustained volume reduction. In this narrative review, we proposed an overview of new strategies for diagnosing and treating post-prostatectomy lymphedema to get the most appropriate and successful patient treatment with an overview of the main artificial intelligence applications in the prevention, diagnosis, and management of lymphedema.

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Section: Near-infrared Fluorescence Imagingmentioning

confidence: 99%

Diagnosis and Treatment of Post-Prostatectomy Lymphedema: What’s New?

et al. 2023

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“…The diversification of imaging modalities, such as X-ray, computed tomography (CT), magnetic resonance imaging (MRI), photoacoustic imaging (PI), positron emission tomography (PET) and fluorescence imaging (FI) has facilitated early diagnoses and targeted therapies. Compared to other well-developed techniques, FI with small-molecule dyes, in the near infrared region (NIR, 700–1000 nm), has been widely applied for real-time detection of biological species and identification of cancer cells or lymph nodes, as well as for the intraoperative image-guided surgical removal of pathological tissues, owing to its high sensitivity, excellent resolution, minimum photodamage to tissues, quick feedback, non-hazardous radiation and, last, but not least, its low costs and sustainability [ 1 , 2 , 3 ]. Most of the traditional fluorescent probes, such as rhodamine, cyanine, or coumarin derivatives, have absorption and emission in the UV-Vis range and the interference with haemoglobin, myoglobin, and other haemoproteins leads to light scattering and impaired tissue penetration.…”

Section: Introductionmentioning

confidence: 99%

A Curcumin-BODIPY Dyad and Its Silica Hybrid as NIR Bioimaging Probes

Gangemi

Salerno

Barattucci

et al. 2022

IJMS

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In this paper we describe the synthesis of a novel bichromophoric system in which an efficient photoinduced intercomponent energy transfer process is active. The dyad consists of one subunit of curcumin and one of BODIPY and is able to emit in the far-red region, offering a large Stokes shift, capable of limiting light scattering processes for applications in microscopy. The system has been encapsulated in MCM-41 nanoparticles with dimensions between 50 and 80 nm. Both the molecular dyad and individual subunits were tested with different cell lines to study their effective applicability in bioimaging. MCM-41 nanoparticles showed no reduction in cell viability, indicating their biocompatibility and bio-inertness and making them capable of delivering organic molecules even in aqueous-based formulations, avoiding the toxicity of organic solvents. Encapsulation in the porous silica structure directed the location of the bichromophoric system within cytoplasm, while the dyad alone stains the nucleus of the hFOB cell line.

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New actors in prostate cancer surgical theatre: are we sharpening the eye with optical imaging?

Gelardi¹,

Antunovic²

2023

Eur J Nucl Med Mol Imaging

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The application of indocyanine green in guiding prostate cancer treatment

Cited by 6 publications

References 49 publications

Diagnosis and Treatment of Post-Prostatectomy Lymphedema: What’s New?

Diagnosis and Treatment of Post-Prostatectomy Lymphedema: What’s New?

A Curcumin-BODIPY Dyad and Its Silica Hybrid as NIR Bioimaging Probes

New actors in prostate cancer surgical theatre: are we sharpening the eye with optical imaging?

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