The application of M12L24 nanocages as cell-specific siRNA delivery agents in vitro

Bobylev, Eduard O.; Zeng, Ye; Weijgertse, Kevin; Koelman, Emma; Meijer, Eline; Bruin, Bas de; Kros, Alexander; Reek, Joost N. H.

doi:10.1016/j.chempr.2023.03.018

Chem

2023

DOI: 10.1016/j.chempr.2023.03.018

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The application of M12L24 nanocages as cell-specific siRNA delivery agents in vitro

Eduard O. Bobylev

Ye Zeng

Kevin Weijgertse

et al.

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Cited by 10 publications

References 67 publications

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Diastereoselective Self‐Assembly of Low‐Symmetry Pd_nL_2n Nanocages through Coordination‐Sphere Engineering**

Molinska,

Tarzia,

Male

et al. 2023

Angewandte Chemie

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Metal‐organic cages (MOCs) are popular host architectures assembled from ligands and metal ions/nodes. Assembling structurally complex, low‐symmetry MOCs with anisotropic cavities can be limited by the formation of statistical isomer libraries. We set out to investigate the use of primary coordination‐sphere engineering (CSE) to bias isomer selectivity within homo‐ and heteroleptic PdnL2n cages. Unexpected differences in selectivities between alternative donor groups led us to recognise the significant impact of the second coordination sphere on isomer stabilities. From this, molecular‐level insight into the origins of selectivity between cis and trans diastereoisomers was gained, highlighting the importance of both host‐guest and host‐solvent interactions, in addition to ligand design. This detailed understanding allows precision engineering of low‐symmetry MOC assemblies without wholesale redesign of the ligand framework, and fundamentally provides a theoretical scaffold for the development of stimuli‐responsive, shape‐shifting MOCs.

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Diastereoselective Self‐Assembly of Low‐Symmetry Pd_nL_2n Nanocages through Coordination‐Sphere Engineering**

Molinska,

Tarzia,

Male

et al. 2023

Angewandte Chemie

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Guest‐Induced “Breathing‐Helical” Dynamic System of a Porphyrinic Metallo‐Organic Cage for Advanced Conformational Manipulation

Dong,

Liu,

Wang

et al. 2024

Angewandte Chemie

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Host‐guest dynamic systems in coordination‐driven metallo‐organic cages have gained significant attentions since their promising applications in chiral separation, drug delivery, and catalytical fields. To maximize guest‐binding affinity, hosts adopting multiple conformations are widely investigated on their structural flexibility for guest accommodation. In this study, a novel metallo‐organic cage S with breathing inner cavity and freely twisted side chains was proposed. Single‐crystal X‐ray diffraction analyses depicted a characteristic “breathing‐helical” dynamic system on the semiflexible framework, which led to an unprecedent co‐crystallisation of racemic and symmetric conformations via the encapsulation locking of C70 guests. By taking advantages of the high binding affinity, selective extraction of C70 was realized. This research provides new ideas for the modification on the helicities of metallo‐organic cages, which could pave a new way for advanced conformational manipulation of supramolecular host systems.

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Diastereoselective Self‐Assembly of Low‐Symmetry Pd_nL_2n Nanocages through Coordination‐Sphere Engineering**

Molinska,

Tarzia,

Male

et al. 2023

Angew Chem Int Ed

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The application of M12L24 nanocages as cell-specific siRNA delivery agents in vitro

Cited by 10 publications

References 67 publications

Diastereoselective Self‐Assembly of Low‐Symmetry Pd_nL_2n Nanocages through Coordination‐Sphere Engineering**

Diastereoselective Self‐Assembly of Low‐Symmetry Pd_nL_2n Nanocages through Coordination‐Sphere Engineering**

Guest‐Induced “Breathing‐Helical” Dynamic System of a Porphyrinic Metallo‐Organic Cage for Advanced Conformational Manipulation

Diastereoselective Self‐Assembly of Low‐Symmetry Pd_nL_2n Nanocages through Coordination‐Sphere Engineering**

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Product

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The application of M12L24 nanocages as cell-specific siRNA delivery agents in vitro

Cited by 10 publications

References 67 publications

Diastereoselective Self‐Assembly of Low‐Symmetry PdnL2n Nanocages through Coordination‐Sphere Engineering**

Diastereoselective Self‐Assembly of Low‐Symmetry PdnL2n Nanocages through Coordination‐Sphere Engineering**

Guest‐Induced “Breathing‐Helical” Dynamic System of a Porphyrinic Metallo‐Organic Cage for Advanced Conformational Manipulation

Diastereoselective Self‐Assembly of Low‐Symmetry PdnL2n Nanocages through Coordination‐Sphere Engineering**

Contact Info

Product

Resources

About

Diastereoselective Self‐Assembly of Low‐Symmetry Pd_nL_2n Nanocages through Coordination‐Sphere Engineering**

Diastereoselective Self‐Assembly of Low‐Symmetry Pd_nL_2n Nanocages through Coordination‐Sphere Engineering**

Diastereoselective Self‐Assembly of Low‐Symmetry Pd_nL_2n Nanocages through Coordination‐Sphere Engineering**