The application of magnetic resonance imaging-guided microwave ablation for lung cancer

Nianlong, Liu; Yang, Bo; Tian-Ming, Chen; Gao, Feng; Yin, Ning; Yu-Huang, Wang; Shen, Wenrong; Chen, Shilin

doi:10.4103/jcrt.jcrt_354_20

Cited by 12 publications

(5 citation statements)

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“…Written informed consent was obtained from all participating patients before they underwent CT-guided percutaneous MWA of their lung tumors. Patients were recruited based on the following eligibility criteria ( 1 ): patients (aged ≥18 years) who were referred to our radiology department for MWA of lung tumors ( 2 ); malignant lung tumors confirmed by histological or cytological diagnosis ( 3 ); re-examination by chest enhanced CT 4–6 weeks after the procedure, which was used as the baseline for evaluation ( 4 ); tumor volume ≥2.5 cm 3 ; and ( 5 ) adequate normal organ function. Patients were excluded if they had undergone radiotherapy or other local or regional treatments before or after MWA.…”

Section: Methodsmentioning

confidence: 99%

Assessment and Prognostic Value of Immediate Changes in Post-Ablation Intratumor Density Heterogeneity of Pulmonary Tumors via Radiomics-Based Computed Tomography Features

Liu

Sun

et al. 2021

Front. Oncol.

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ObjectivesTo retrospectively observe the instantaneous changes in intratumor density heterogeneity after microwave ablation (MWA) of lung tumors and to determine their prognostic value in predicting treatment response and local tumor progression (LTP).MethodsPre- and post-MWA computed tomography (CT) images of 50 patients (37-males; 13-females; mean-age 65.9 ± 9.7y, 39 primary and 11 metastasis) were analyzed to evaluate changes in intratumor density. Global, regional, and local scale radiomics features were extracted to assess intratumor density heterogeneity. In four to six weeks, chest enhanced CT was used as the baseline evaluation of treatment response. The correlations between the parametric variation immediately after ablation and the visual score of ablation response (Rvisu) were analyzed by nonparametric Spearman correlation analysis. The 1-year LTP discrimination power was assessed using the area under the receiver operating characteristic (ROC) curves. A Cox proportional hazards regression model was used to identify the independent prognostic features.ResultsAlthough no significant volume changes were observed after ablation, the radiomics parameters changed in different directions and degrees. The mean intensity value from baseline CT image was 30.3 ± 23.2, and the post-MWA CT image was -60.9 ± 89.8. The ratio of values change was then calculated by a unified formulation. The largest increase (522.3%) was observed for cluster prominence, while the mean CT value showed the largest decline (321.4%). The pulmonary tumors had a mean diameter of 3.4 ± 0.8 cm. Complete ablation was documented in 36 patients. Significant correlations were observed between Rvisu and quantitative features. The highest correlations were observed for changes in local features after MWA, with r ranging from 0.594 to 0.782. LTP developed in 22 patients. The Cox regression model revealed Δcontrast% and response score as independent predictors (Δcontrast%: odds ratio [OR]=5.61, p=0.001; Rvisu: OR=1.73, p=0019). ROC curve analysis showed that Δcontrast% was a better predictor of 1-year LTP. with higher sensitivity (83.5% vs. 71.2%) and specificity (87.1% vs. 76.8%) than those for Rvisu.ConclusionsThe changes in intratumor density heterogeneity after MWA could be characterized by analysis of radiomics features. Real-time density changes could predict treatment response and LTP in patients with pulmonary tumors earlier, especially for tumors with larger diameters.

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Section: Methodsmentioning

confidence: 99%

Assessment and Prognostic Value of Immediate Changes in Post-Ablation Intratumor Density Heterogeneity of Pulmonary Tumors via Radiomics-Based Computed Tomography Features

Liu

Sun

et al. 2021

Front. Oncol.

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“…Recent reports have featured open high-field systems that provide improved visualization of lesions <1 cm, bullae, and small vessels. 11,[20][21][22][23] Of interest is also the option to operate the closed-bore (70 cm wide, 145 cm long) 1.5 T Magnetom Aera (Siemens Healthineers, Erlangen, Germany) at 0.55 T (Fig. 1), which results in reduced image distortion by virtue of the field homogeneity of this system configuration (Fig.…”

Section: Currently Available Hardware For Mr-guided Thoracic Interven...mentioning

confidence: 99%

“…The authors reported that the ablation zone appeared "more obvious" to them on MRI compared with CT, based on their experience with CT-guided ablations. 22 Nian-Long et al 23 reported a study comparing CT to MRguidance for MWA of 44 pulmonary tumors in 43 patients using a 3.0 T system (Ingenia, Philips) with SENSE (SENSitivity Encoding) technology, a 16-channel body coil (GE), the VISON MTC-3C ablation system with 18-G 18 cm nonmagnetic antennas and local anesthesia. While the authors report that the imaging modality was randomly assigned, they fail to specify inclusion and exclusion criteria.…”

Section: Mwamentioning

confidence: 99%

“…Access to open-bore systems, however, may be limited in less well-resourced healthcare settings. Recent reports have featured open high-field systems that provide improved visualization of lesions <1 cm, bullae, and small vessels 11,20–23. Of interest is also the option to operate the closed-bore (70 cm wide, 145 cm long) 1.5 T Magnetom Aera (Siemens Healthineers, Erlangen, Germany) at 0.55 T (Fig.…”

Section: Currently Available Hardware For Mr-guided Thoracic Interven...mentioning

confidence: 99%

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Magnetic Resonance Imaging for Guidance and Follow-up of Thoracic Needle Biopsies and Thermal Ablations

Kashani

Campbell-Washburn

Murphy

et al. 2022

Journal of Thoracic Imaging

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Magnetic resonance imaging (MRI) is used for the guidance and follow-up of percutaneous minimally invasive interventions in many body parts. In the thorax, computed tomography (CT) is currently the most used imaging modality for the guidance and follow-up of needle biopsies and thermal ablations. Compared with CT, MRI provides excellent soft tissue contrast, lacks ionizing radiation, and allows functional imaging. The role of MRI is limited in the thorax due to the low hydrogen proton density and many air-tissue interfaces of the lung, as well as respiratory and cardiac motion. Here, we review the current experience of MR-guided thoracic needle biopsies and of MR-guided thermal ablations targeting lesions in the lung, mediastinum, and the chest wall. We provide an overview of MR-compatible biopsy needles and ablation devices. We detail relevant MRI sequences and their relative advantages and disadvantages for procedural guidance, assessment of complications, and long-term follow-up. We compare the advantages and disadvantages of CT and MR for thoracic interventions and identify areas in need of improvement and additional research.

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“…In addition to systemic therapy, the principal local therapies for lung cancer and lung metastases include surgical resection, external-beam radiotherapy, and thermal ablation procedures such as radiofrequency ablation (RFA) and microwave ablation (MWA) (3). Compared to RFA, MWA is reportedly a more effective treatment for lung tumors (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

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The application of magnetic resonance imaging-guided microwave ablation for lung cancer

Cited by 12 publications

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Assessment and Prognostic Value of Immediate Changes in Post-Ablation Intratumor Density Heterogeneity of Pulmonary Tumors via Radiomics-Based Computed Tomography Features

Assessment and Prognostic Value of Immediate Changes in Post-Ablation Intratumor Density Heterogeneity of Pulmonary Tumors via Radiomics-Based Computed Tomography Features

Magnetic Resonance Imaging for Guidance and Follow-up of Thoracic Needle Biopsies and Thermal Ablations

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