The application of mesoporous silica nanoparticle family in cancer theranostics

Yin, Feng; Panwar, Nishtha; Tng, Danny Jian Hang; Tjin, Swee Chuan; Wang, Kuan; Yong, Ken‐Tye

doi:10.1016/j.ccr.2016.04.019

Cited by 150 publications

(89 citation statements)

References 280 publications

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“…But the promising properties of Meloxicam as, COX-II inhibitor, mainly associated with cancer cells, promoting cytotoxicity enable this compound to be a potential antitumor agent 19 . Mesoporous silica nanoparticles have emerged as promising drug delivery systems which improves the efficacy of targeted therapeutic agents to the site of actions 20,21 . They have been extensively used for drug loading of various bioactive molecules and also hydrophilic and hydrophobic drugs 22 -24 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2017

IJPSR

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ABSTRACT:Polymer functionalised mesoporous silica nanoparticles hold great promise to enhance drug targeting and cell internalisation for cancer cells. Since the presence of abundant folate receptors on cancer cells, folic acid functionalised mesoporous silica nanoparticles (MSN) were used as folate marker and polyethyleneimine was used to improve cell internalisation. Meloxicam was loaded into the pores of nanoparticles through -NH 2 linker and polyethyleneimine-folic acid was grafted onto mesoporous silica nanoparticles. The functionalised MSN were characterised for particle size, surface charge, and elemental analysis. The release of meloxicam from the functionalised nanoparticles exhibited sustained release through membrane diffusion drug release method. Cell viability and cytotoxicity study was performed using HT-29 Human Colon cancer cell line as an in-vitro model. The results of scanning electron microscopy and energy dispersive spectroscopy demonstrated the presence of SiO 2 group and the particle size of functionalised nanoparticles to be between 200-800 nm. The zeta potential of the coated MSN exhibited positive surface charge, enhancing the targeting of negatively charged cancer cells and cell internalisation. Moreover, the cytotoxicity studies indicated the uptake of Meloxicam from the functionalised particles. The study provides evidence that polymeric coating eased the cell internalisation of MSN into the cancer cells. Results indicated that Meloxicam delivered with the help of mesoporous silica nanoparticles coated with polyethyleneimine and folic acid increased the in vitro cytotoxicity, enhancing antitumor activity.

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Section: Discussionmentioning

confidence: 99%

Untitled

2017

IJPSR

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“…In particular, the hollow structured MSNs can load as much as 1 g of lipophilic drug molecules per gram of silica). 14 Compared with single modality imaging or therapeutic agents, multifunctional NPs can show the desired synergistic properties to endow early-stage diagnosis, provide more comprehensive information of the tumour region and improve the treatment efficacy. 15–23 …”

Section: Introductionmentioning

confidence: 99%

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

et al. 2017

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Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites. Compared with normal tissue, the tumour microenvironment has some unique properties, such as vascular abnormalities, hypoxia and acidic pH. There are many types of cells including tumour cells, macrophages, immune and fibroblasts cells, fed by defective blood vessels in the solid tumour. Exploiting the tumour microenvironment can benefit the design of nanoparticles for enhanced therapeutic effectiveness. In this review article, we summarized the recent progress in various nanoformulations for cancer therapy, with special emphasis on tumour microenvironment stimuli-responsive ones. Numerous tumour microenvironment modulation strategies with promising cancer therapeutic efficacy have also been highlighted. Future challenges and opportunities of design consideration are also discussed in details. We believe that these tumour microenvironment modulation strategies offer a good chance for the practical translation of nanoparticle formulas into clinic.

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“…Nowadays, tumor removal through surgery, chemotherapy, and radiotherapy are considered as the most reliable treatments of cancer (Piktel et al, ). In chemotherapy, various chemotherapeutics are administered for treating malignancy (Feng et al, ). Doxorubicin, paclitaxel, cisplatin, methotrexate, and 5‐fluorouracil are the major anticancer drugs used for cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

“…Owing to the limitations of conventional drug delivery systems (DDS), the development of new strategies for drug delivery at the target site is imperative. Targeted TDDS are advantageous to reduce MDR, side effects, recurrence, and metastasis as well as to maximize therapeutic efficacy (Feng et al, ). In this context, nanoscale technology has proven its significance in fabricating TDDS, followed by its use in diagnosing diseases and treating cancer (Li et al, ).…”

Section: Introductionmentioning

confidence: 99%

Targeted and stimuli–responsive mesoporous silica nanoparticles for drug delivery and theranostic use

Aquib

Farooq

Banerjee

et al. 2019

J Biomedical Materials Res

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For cancer therapy, the usefulness of mesoporous silica nanoparticles (MPSNPs) has been widely discussed, likely due to its inorganic nature and excellent structural features. The MPSNPs‐based chemotherapeutics have been promisingly delivered to their target sites that help to minimize side effects and improve therapeutic effectiveness. A wide array of studies have been conducted to functionalize drug‐loaded MPSNPs using targeting ligands and stimuli‐sensitive substances. In addition, anticancer drugs have been precisely delivered to their target sites using MPSNPs, which respond to multi‐stimuli. Furthermore, MPSNPs have been extensively tested for their safety and compatibility. The toxicity level of MPSNPs is substantially lower as compared to that of colloidal silica; however, in oxidative stress, they exhibit cytotoxic features. The biocompatibility of MPSNPs can be improved by modifying their surfaces. This article describes the production procedures, functionalization, and applications of biocompatible MPSNPs in drug delivery.

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The application of mesoporous silica nanoparticle family in cancer theranostics

Cited by 150 publications

References 280 publications

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Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

Targeted and stimuli–responsive mesoporous silica nanoparticles for drug delivery and theranostic use

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