1996
DOI: 10.3109/00365529609031971
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The Application of Microridge Analysis in the Diagnosis of Gastro-oesophageal Reflux Disease

Abstract: Despite the significant relationship between endoscopic and light microscopic oesophagitis and abnormal pH monitoring microridge analysis did not correlate with any of these variables

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Cited by 5 publications
(4 citation statements)
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“…Biopsies showing intestinal metaplasia, identical to Barrett's, which are obtained from the gastric cardia do not indicate the same malignant potential as biopsies from the esophagus and actually do not even confirm GERD (21). There is no value for histologic examination of normal appearing squamous mucosa to either confirm or exclude pathologic acid reflux (22,23).…”
Section: Level Of Evidence: IIImentioning
confidence: 99%
“…Biopsies showing intestinal metaplasia, identical to Barrett's, which are obtained from the gastric cardia do not indicate the same malignant potential as biopsies from the esophagus and actually do not even confirm GERD (21). There is no value for histologic examination of normal appearing squamous mucosa to either confirm or exclude pathologic acid reflux (22,23).…”
Section: Level Of Evidence: IIImentioning
confidence: 99%
“…Mature microridges are relatively stable wall-like protrusions, arranged in a labyrinthine fashion 1116 . They are shown to be present on several non-cornified epithelia in various species across vertebrate phyla, making them one of the more widespread actin protrusions 9,11,1726 . Microridges are thought to have important roles in mucus retention, abrasion resistance and increasing the tensile strength of the apical domain 9,14,27,28 .…”
Section: Introductionmentioning
confidence: 99%
“…These cases must be confirmed with other methods (pH testing or therapeutic trial). There is little value for histological examination of normal-appearing squamous mucosa to either confirm or exclude pathological acid reflux (15,16 Although endoscopy allows for the evaluation of esophageal mucosa, the presence or absence of mucosal injury does not provide proof that the patient's symptoms are or are not related to GERD. Many patients with typical GERD symptoms and increased esophageal acid exposure do not have esophagitis (17).…”
Section: Endoscopy In Gerdmentioning
confidence: 99%