For decades, the chemical industry has been facing challenges including energy conservation, environmental protection, quality improvement, and increasing production efficiency. To address these problems, various methods are being studied, such as research on fault diagnosis for the efficient use of facilities and medium-term forecasting with small data, where many systems are being applied to improve production efficiency. The problem considered in this study is the problem of predicting time-series Controlled Variables (CV) with machine learning, which is necessary to utilize an Advanced Process Control (APC) system in a petrochemical plant. In an APC system, the most important aspect is the prediction of the controlled variables and how the predicted values of the controlled variables should be modified to be in the user’s desired range. In this study, we focused on predicting the controlled variables. Specifically, we utilized various machine learning techniques to predict future controlled variables based on past controlled variables, Manipulated Variables (MV), and Disturbance Variables (DV). By using a time delay as a parameter and adjusting its value, you can analyze the relationship between past and future data and improve forecasting performance. Currently, the APC system is controlled through mathematical modeling and research, The time-series data of controlled variables, manipulated variables, and disturbance variables are predicted through machine learning models to compare performance and measure accuracy. It is becoming important to change from mathematical prediction models to data-based machine learning predictions. The R-Squared (R2) and Mean Absolute Percentage Error (MAPE) metric results of this study demonstrate the feasibility of introducing an APC system using machine learning models in petrochemical plants.