The application of multifunctional nanomaterials in Alzheimer’s disease: A potential theranostics strategy

Current Progress on Neuroprotection Induced by Artemisia, Ginseng, Astragalus, and Ginkgo Traditional Chinese Medicines for the Therapy of Alzheimer’s Disease

“…An important aspect that may limit the therapeutic applications of these TCM for AD therapy is related to their low solubility, short half-life, and poor bioavailability [ 238 ]. To increase bioavailability, reduce metabolic degradation, and improve the transfer through the blood-brain-barrier, new pharmaceutical technologies are required such as micro- and nanoencapsulation [ 239 , 240 ]. The dosage required for beneficial safe effects in humans and without adverse reactions and drug interactions with other drugs in use are also important factors to be taken into consideration that needs longitudinal investigations.…”

Bioinspired synthetic polymers-based inhibitors of Alzheimer's amyloid-β peptide aggregation

“…89 Furthermore, nanomaterials have appeared as another type of promising inhibitors for the treatment of AD, due to their potential to cross the blood-brain barrier (BBB), high bioavailability and efficacy, and amenability to surface functionalization, as has been reviewed elsewhere. 90,91 Various inorganic nanoparticles (NPs) (including gold nanoparticles (AuNPs), magnetic nanoparticles, and quantum dots) and carbon nanomaterials (including carbon nanotubes, fullerenes, and graphenes) have been identified as excellent antiamyloid agents for AD treatment. 92 Bioinspired synthetic polymers have been recognized to present an excellent potential for their various biological applications.…”

“…In a consecutive report, Moore and co-workers further investigated the dependence of polymer MW of mPPCs on the rate and extent of disassembly of the preformed Aβ fibrils in vitro. 138 The above macromolecular Aβ inhibitors mP-iAβ 5 at a constant 7% peptide loading were synthesized with a broad range of MW 22,46,90, 12). 139 ThT assay and AFM studies revealed that mPPCs-LPFFD (3% loading, 77 kDa) and mPPCs-LPFFN (9% loading, 43 kDa) fully prevented the fibril formation, and mPPCs-G (mG)L(mG)F(mG)A (12% loading, 18 kDa) prolonged the lag time to about 24 h. It was found that the nature of the ligands in mPPCs plays a key role to achieve effective inhibition and in comparison to the other ligands, the negatively charged LPFFD-based mPPCs conjugates with 7% loading exhibited maximum inhibition for all MWs.…”

Involvement of Phytochemical-Encapsulated Nanoparticles’ Interaction with Cellular Signalling in the Amelioration of Benign and Malignant Brain Tumours

“…Nanoparticles K16ApoE were highly specific for the Dutch A40 vasculotropic peptide, often present in the cerebral vasculature [ 136 ]. Additionally, the nanoparticles developed can be used in hydrophobic therapeutic and imaging agents, enabling the early detection and treatment of pathological changes caused by amyloidosis via magnetic resonance imaging (MRI) [ 137 ].…”