The application of nanoparticles in point-of-care testing (POCT) immunoassays

Abstract

The Covid-19 pandemic let people recognize the importance of the fast and timely detection of pathogens. Recent advances in point-of-care testing (POCT) technology have shown promising results for rapid diagnosis....

Quantitative injection strip platform using water-soluble paper and magnet based on a lateral flow assay

“…23,24 To indicate the detection results, the LFA strip utilizes various labels such as gold nanoparticles, carbon nanoparticles, fluorescent nanoparticles, latex beads, selenium, colloidal carbon, and quantum dots. 25,26 Gold nanoparticles are easy to functionalize and have optical properties that appear when the density per unit area increases; thus, the results can be confirmed with naked eye without any additional equipment to check the detection results. 27…”

A new colorimetric aptasensor for paraquat detection based on the designed aptamer with multiple paraquat binding sites in combination with gold nanoparticles

“…16 Additionally, the unique optical properties of AuNPs cause their color to change based on their states: free AuNPs appearing as wine red and aggregated AuNPs exhibiting shades of purple or blue. 17 Taking advantage of this phenomenon, detection techniques have been devised utilizing AuNPs to enable qualitative and quantitative analysis of diverse target molecules. On the basis of this principle, prior research has established a colorimetric detection technique for paraquat by using an aptamer and inducing the aggregation of AuNPs through cation molecules.…”

Nanoparticle‐Based Bioaffinity Assays: From the Research Laboratory to the Market

“…Many reviews have been published to keep up with the large number of original research articles on new NP‐based detection schemes. [ 3–5 ] There is, however, a need for a critical evaluation of the most suitable approaches for commercialization because many recent materials‐oriented papers have claimed analysis capabilities that are either impractical, are not tested for selectivity, or are otherwise deficient.…”