The application of “Omics” to accelerate precision medicine in Supportive Care in Cancer

Sonis, Stephen T.; Patel, Jai N.; Ashbury, Fredrick D.

doi:10.1007/s00520-021-06519-9

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…The dependence of such bell-shaped curve data ignores those patients at either end – those who are hyper-responders or those who do not respond at all. Being able to prospectively identify into which category a particular patient falls informs providers as to dosing decisions or whether to even expose the patient to the proposed treatment [ 9 ]. For example, an analgesic at one dose might be very effective in one individual and useless in another.…”

Section: Opportunities For Precision Medicinementioning

confidence: 99%

Precision medicine for risk prediction of oral complications of cancer therapy–The example of oral mucositis in patients receiving radiation therapy for cancers of the head and neck

Sonis

2022

Front. Oral. Health

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Oral complications of cancer therapy are common, markedly symptomatic, negatively impact patients' quality of life, and add significantly to the cost of care. Patients' risk of treatment-related toxicities is not uniform; most patients suffer at least one side effect, while others tolerate treatment without any. Understanding those factors which impact risk provides opportunities to customize cancer treatment plans to optimize tumor kill and minimize regimen-related toxicities. Oral mucositis (OM) is an iconic example of a clinically significant and common complication of head and neck radiotherapy. Individuals' OM risk is governed by the cumulative impact of factors related to treatment, the tumor, and the patient. In addition to OM risk prediction, a second opportunity to apply precision medicine will evolve as viable treatment options become available. Patients vary widely in how well or poorly they respond to specific treatments. What works well in one individual, might fail in another. Prospective determination of the likelihood of a patient's response or non-response is based on a range of biological interactions. Coupled with risk determination, the application of precision medicine will allow caregivers, patients, and payers to integrate risk/benefit to optimize the probability that the best treatment is be given to the most appropriate patients.

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Section: Opportunities For Precision Medicinementioning

confidence: 99%

Precision medicine for risk prediction of oral complications of cancer therapy–The example of oral mucositis in patients receiving radiation therapy for cancers of the head and neck

Sonis

2022

Front. Oral. Health

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Nurses’ stress, anxiety, depression, and burnout in the workplace: A correlational study

al.¹

2022

Int. j. adv. appl. sci.

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Nursing burnout has been linked to stress, anxiety, and depression. Increased stress and anxiety have been closely related to burnout. This study's major goal has been to determine the association of these variables in the context of nursing practice. This descriptive correlational study aimed at determining the relationship between stress, anxiety, and depression with burnout among the 307 purposive nurse samples from participating government and private hospitals in Manila, Pampanga, and Tarlac, Philippines collected between March and June 2020 using a 21-item Depression Anxiety Stress Scale (DASS-21) and a 16-item Oldenburg Burnout Inventory (OLBI) instruments. Mostly with a normal level of stress, anxiety, and depression, the nurses had been also found to have a moderate level of overall burnout and were moderately disengaged, and exhausted. Using IBM SPSS v.26, the study utilized Pearson product-moment correlation which found that nurses’ stress had significant relationships (p=.000) with burnout, disengagement, and exhaustion; anxiety to burnout, disengagement, and exhaustion; and depression with burnout, disengagement, and exhaustion. The degree of stress, anxiety, and depression has significantly shown direct correspondence which calls for a deeper examination of sources and factors. Nurses' experience of burnout is associated with the service-oriented features of the profession. The emphasis is on the need for treatments to guarantee that burnout does not lead to higher staff turnover, degraded health care, decreased productivity, and decreased professional fulfillment. A systems approach to burnout prevention and treatment should investigate the relevant factors that are addressed in the organizational, group, and individual efforts. This study offers a remarkable hypothetical underpinning for nurses' ability to handle stressful workplace situations with resilience and professionalism.

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The application of “Omics” to accelerate precision medicine in Supportive Care in Cancer

Cited by 2 publications

References 12 publications

Precision medicine for risk prediction of oral complications of cancer therapy–The example of oral mucositis in patients receiving radiation therapy for cancers of the head and neck

Precision medicine for risk prediction of oral complications of cancer therapy–The example of oral mucositis in patients receiving radiation therapy for cancers of the head and neck

Nurses’ stress, anxiety, depression, and burnout in the workplace: A correlational study

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