The application of organoids in toxicity test of environmental pollutants

Fang, Yuting; Akhtar, Huraira; Wang, Ji

doi:10.26599/co.2024.9410002

Cell Organoid

2024

DOI: 10.26599/co.2024.9410002

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The application of organoids in toxicity test of environmental pollutants

Yuting Fang,

Huraira Akhtar,

Ji Wang

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2024

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Patient‐derived ovarian cancer organoid carries immune microenvironment and blood vessel keeping high response to cisplatin

Zhao,

Wang,

Deng

et al. 2024

MedComm

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Ovarian cancer is high recurrence and mortality malignant tumor. The most common ovarian cancer was High‐Grade Serous Ovarian Cancer. However, High‐Grade Serous Ovarian Cancer organoid is rare, which organoid with patient immune microenvironment and blood vessels even absence. Here, we report a novel High‐Grade Serous Ovarian Cancer organoid system derived from patient ovarian cancer samples. These organoids recapitulate High‐Grade Serous Ovarian Cancer organoids' histological and molecular heterogeneity while preserving the critical immune microenvironment and blood vessels, as evidenced by the presence of CD34+ endothelial cells. Whole exome sequencing identifies key mutations (CSMD3, TP53, GABRA6). Organoids show promise in testing cisplatin sensitivity for patients resistant to carboplatin and paclitaxel, with notable responses in cancer proteoglycans and p53 (TP53) signaling, like ACTG/ACTB1/AKT2 genes and BBC3/MDM2/PERP. Integration of immune microenvironment and blood vessels enhances potential for novel therapies like immunotherapies and angiogenesis inhibitors. Our work may provide a new detection system and theoretical basis for ovarian cancer research and individual therapy.

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Patient‐derived ovarian cancer organoid carries immune microenvironment and blood vessel keeping high response to cisplatin

Zhao,

Wang,

Deng

et al. 2024

MedComm

View full text Add to dashboard Cite

show abstract

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The application of organoids in toxicity test of environmental pollutants

Cited by 1 publication

References 159 publications

Patient‐derived ovarian cancer organoid carries immune microenvironment and blood vessel keeping high response to cisplatin

Patient‐derived ovarian cancer organoid carries immune microenvironment and blood vessel keeping high response to cisplatin

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