The application of pectin and chitooligosaccharides for the preparation of nisin-loaded nanoparticles with different surface charges

Pachaleva, Jolita; Gruškienė, Rūta; Bočkuvienė, Alma; Sereikaitė, Jolanta

doi:10.1007/s10570-023-05380-9

Cellulose

2023

DOI: 10.1007/s10570-023-05380-9

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The application of pectin and chitooligosaccharides for the preparation of nisin-loaded nanoparticles with different surface charges

Jolita Pachaleva

Rūta Gruškienė

Alma Bočkuvienė

et al.

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2024

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Cited by 2 publications

References 40 publications

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Fucoidan as a carrier of antimicrobial peptide: Preparation and characterization of nisin-loaded particles

Gruškienė,

Galinskaitė,

Kavleiskaja

et al. 2024

LWT

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Fucoidan as a carrier of antimicrobial peptide: Preparation and characterization of nisin-loaded particles

Gruškienė,

Galinskaitė,

Kavleiskaja

et al. 2024

LWT

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Synthesis and Characterization of a Novel Chitosan-Based Nanoparticle–Hydrogel Composite System Promising for Skin Wound Drug Delivery

Huang,

Hao,

Chen

et al. 2024

Marine Drugs

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As a natural preservative, nisin is widely used in the food industry, while its application in biomedicine is limited due to its susceptibility to interference from external conditions. In this study, a nanoparticle–hydrogel composite system was designed to encapsulate and release nisin. Nisin nanoparticles were identified with a smooth, spherical visual morphology, particle size of 122.72 ± 4.88 nm, polydispersity coefficient of 0.473 ± 0.063, and zeta potential of 23.89 ± 0.37 mV. Based on the sample state and critical properties, three temperature-sensitive hydrogels based on chitosan were ultimately chosen with a rapid gelation time of 112 s, outstanding reticular structure, and optimal swelling ratio of 239.05 ± 7.15%. The composite system exhibited the same antibacterial properties as nisin, demonstrated by the composite system’s inhibition zone diameter of 17.06 ± 0.83 mm, compared to 20.20 ± 0.58 mm for nisin, which was attributed to the prolonged release effect of the hydrogel at the appropriate temperature. The composite system also demonstrated good biocompatibility and safety, making it suitable for application as short-term wound dressings in biomedicine due to its low hemolysis rate of less than 2%. In summary, our nanoparticle-based hydrogel composite system offers a novel application form of nisin while ensuring its stability, thereby deepening and broadening the employment of nisin.

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The application of pectin and chitooligosaccharides for the preparation of nisin-loaded nanoparticles with different surface charges

Cited by 2 publications

References 40 publications

Fucoidan as a carrier of antimicrobial peptide: Preparation and characterization of nisin-loaded particles

Fucoidan as a carrier of antimicrobial peptide: Preparation and characterization of nisin-loaded particles

Synthesis and Characterization of a Novel Chitosan-Based Nanoparticle–Hydrogel Composite System Promising for Skin Wound Drug Delivery

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