The application of photodynamic therapy in plastic and reconstructive surgery

Wu, Min; Huang, Xiaoyu; Gao, Lu; Zhou, Guoyu; Xie, Feng

doi:10.3389/fchem.2022.967312

Cited by 3 publications

(1 citation statement)

References 110 publications

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“…Despite the continuous development of science towards an understanding of the mechanisms of cancer formation, there were large clinical trials conducted in recent years [ 1 , 2 ], which have resulted in the creation of a new generation of targeted drugs [ 3 ]. However, the treatment of some cancers is still ineffective.…”

Section: Introductionmentioning

confidence: 99%

PDT-Induced Activation Enhanced by Hormone Response to Treatment

Domka,

Bartusik-Aebisher,

Przygoda

et al. 2023

IJMS

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Photodynamic therapy (PDT) is a medical treatment with the use of a photosensitizing agent (PS), which, when activated by light, results in selective tissue damage with a cytotoxic effect on tumor cells. PDT leads to the induction of an acute-phase response, which results in the involvement of adrenal glucocorticoid (GC) hormones. PDT, by activating the hormonal response, affects the treatment of cancer. GC release is observed due to adrenal activity, which is driven by changes in the hypothalamic pituitary–adrenal axis triggered by stress signals emanating from the PDT treated tumor. The hormones released in this process in the context of the PDT-induced acute-phase response perform many important functions during anticancer therapy. They lead, among other things, to the systemic mobilization of neutrophils and the production of acute-phase reagents, and also control the production of immunoregulatory proteins and proteins that modulate inflammation. GCs can radically affect the activity of various inflammatory and immune cells, including the apoptosis of cancer cells. A better understanding of the modulation of GC activity could improve the outcomes of cancer patients treated with PDT.

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Section: Introductionmentioning

confidence: 99%

PDT-Induced Activation Enhanced by Hormone Response to Treatment

Domka,

Bartusik-Aebisher,

Przygoda

et al. 2023

IJMS

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Reversing Reprogramming of Cancer Cell Metabolism by Singlet Oxygen Triggered Release of Dichloroacetate Enhances Photodynamic Cytotoxicity

Zhou,

Wang,

Yan

et al. 2024

ChemPhotoChem

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Cancer cells change their glucose metabolism towards lactic acid production for various defensive and proliferative advantages. Dichloroacetate (DCA) is an inhibitor of a key enzyme and thus, changes back the OX‐PHOS to glycolysis ratio. We designed and synthesized a singlet oxygen triggered source of dichloroacetate which releases this inhibitor during photodynamic singlet oxygen generation. Synergistic action of DCA and singlet oxygen results in significant enhancement of photocytotoxicity. The results suggest that this approach could offer significant improvement in the therapeutic outcome of PDT.

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15.5 W, pulsed 630 nm generation based on Raman fiber laser and second-harmonic generation

Lee,

Kim,

Lee

et al. 2024

Opt. Express

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We present a high-power, nanosecond 630 nm beam generation based on Raman conversion and second-harmonic generation (SHG). 116.2 W, single-mode 1080 nm fiber laser based on 10/125 µm optical fiber is used as a pump source for Raman conversion and the 1260 nm seed laser diode helps the amplification of third-order Raman conversion, which results in 63.7 W at 1260 nm with 54.8% Raman conversion efficiency. SHG to 630 nm is based on type-I noncritical phase-matching conditions with bismuth triborate (BIBO) nonlinear crystal. The average power of 630 nm is 15.5 W at a repetition rate of 9.26 MHz, a pulse width of 16.0 ns, and a SHG efficiency of 24.4%. This result can facilitate the generation of a high-power visible light source with good beam quality at a specific wavelength.

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The application of photodynamic therapy in plastic and reconstructive surgery

Cited by 3 publications

References 110 publications

PDT-Induced Activation Enhanced by Hormone Response to Treatment

PDT-Induced Activation Enhanced by Hormone Response to Treatment

Reversing Reprogramming of Cancer Cell Metabolism by Singlet Oxygen Triggered Release of Dichloroacetate Enhances Photodynamic Cytotoxicity

15.5 W, pulsed 630 nm generation based on Raman fiber laser and second-harmonic generation

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