The Application of Response Surface Methodology in Hydrotropic Microwave Assisted Extraction of Andrographolide

Hartati, Indah; Kurniasari, Laeli; Anas, Yance

doi:10.14266/ajoct110-3

Cited by 2 publications

(3 citation statements)

References 11 publications

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“…Hydrotropes are chemicals that increase the solubility of hydrophobic molecules, such as monoterpene in a water-based hydrotrope solution (Hartati et al 2021). Hydrotropic solubilization has been applied in the separation of terpene, such as andrographolide from Andrographis paniculata Ness (Hartati, Anas, and Kurniasari 2015), abiatane diterpenoid (carnosic acid) from rosemary (Mazaud et al 2020), and eugenol from clove buds (Ghule and Desai 2021). Sodium benzoate is applied in the hydrotropic separation of andrographolide (Hartati, Anas, and Kurniasari 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Hydrotropic solubilization has been applied in the separation of terpene, such as andrographolide from Andrographis paniculata Ness (Hartati, Anas, and Kurniasari 2015), abiatane diterpenoid (carnosic acid) from rosemary (Mazaud et al 2020), and eugenol from clove buds (Ghule and Desai 2021). Sodium benzoate is applied in the hydrotropic separation of andrographolide (Hartati, Anas, and Kurniasari 2015). Short-chain alkyl polyethyene glycol ethers are used to separate carnosic acid from rosemary (Mazaud et al 2020).…”

Section: Introductionmentioning

confidence: 99%

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Microwave Assisted Hydrotropic Distillation of Myrcene-Rich Essential Oil of Cymbopogon Citratus

Sediawan¹,

Hartati²,

Sulistyo³

et al. 2023

IJTech

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Myrcene can be used as a versatile starting material for a myriad product for various applications. The drawbacks of the available myrcene separation techniques promote the investigation of application of environmentally clean, faster, more powerful, and cheaper methods. The combination of microwave heating system and application of urea in hydrotropic-based distillation of myrcene-rich essential oil of Cymbopogon Citratus was investigated in this work. A mathematical model of microwave assisted hydrotropic distillation (MAHtD) of essential oil based on the diffusion-control assumption is also proposed and validated. The MAHtD of C. citratus were performed by varying urea concentrations (20-30%) and temperature (105-110°C). The essential oil composition as well as its concentration were analyzed and determined by applying GC-MS. Research result shows that urea is proved as a good hydrotrop for MAHtD of myrcene-rich essential oil of C. citratus. MAHtD performed with 25% urea at a temperature of 105°C for 10 minutes gives a high myrcene content of up to 53.53%. The obtained myrcene-rich essential oil of C. citratus can be investigated for its utilization in various types of applications. Moreover, the proposed model was validated with the experimental data of MAHtD performed at a solid-liquid ratio of 1:10, 25% urea solution, and a temperature of 105°C. The experimental data show a good agreement with the proposed model with SSE of 0.033. The obtained effective diffusivity of the essential oil and the Henry constant in which essential for industrial scale-up process are 2.245 𝑥10 −7 𝑐𝑚 2 /𝑠 and 0.42, respectively. The effective diffusivity value was higher than those obtained from hydro distillation and microwave-assisted hydro distillation of other essential oil, which shows that urea, is a good solubilizing agent for C. citratus essential oil.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microwave Assisted Hydrotropic Distillation of Myrcene-Rich Essential Oil of Cymbopogon Citratus

Sediawan¹,

Hartati²,

Sulistyo³

et al. 2023

IJTech

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show abstract

“…Hydrotropes were also proved to increase the solubility of slightly water soluble androgpraholide. Compared to urea and sodium acetate, sodium benzoate is more suitable in the androgpraholide microwave assisted extraction 11 .…”

Section: Introductionmentioning

confidence: 99%

Mathematical Model of the Hydrotropic Microwave Assisted Extraction of Anti Malarial Agent from Andrographis Paniculata

2015

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The drugs traditionally used to treat uncomplicated malaria have become ineffective, due to the development of drug resistance. It has led to a widespread promotion of artemisinin-based combination therapy (ACT) as a strategy for effective management of Plasmodium falciparum malaria. The main drawback of the ACTs is their high cost. Hence, many phytoconstituents are currently investigated for their antimalarial activity. One of them is andrographolide of Andrographis paniculata (Burm.f.) Wall. A combination of microwave assisted-extraction and the utilization of hydrotrope as the extraction medium is already proved as a potential safe alternative for the separation of andrographolide. Mathematical models of extraction plays a crucial role in basic research of phytoconstituent separation; they are not yet available for hydrotropic-microwave assisted extraction of andrographolide. Therefore, there is a need to conduct a scientific study in this field. The mathematical model is a useful engineering tool for equipment optimization, simulation, design and control, allowing theoretical description of the process and evaluation of the kinetic constant. The aim of this work was to model the kinetics of hydrotropic-microwave assisted extraction of andrographolide. The kinetics of hydrotropic-microwave assisted extraction of andrographolide was studied for two different powers of the microwave extractor (10 % and 30 %). A second order kinetic model describes the solid liquid extraction process of andrographolide from Andrographis paniculata (Burm.f.) Wall.

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The Application of Response Surface Methodology in Hydrotropic Microwave Assisted Extraction of Andrographolide

Cited by 2 publications

References 11 publications

Microwave Assisted Hydrotropic Distillation of Myrcene-Rich Essential Oil of Cymbopogon Citratus

Microwave Assisted Hydrotropic Distillation of Myrcene-Rich Essential Oil of Cymbopogon Citratus

Mathematical Model of the Hydrotropic Microwave Assisted Extraction of Anti Malarial Agent from Andrographis Paniculata

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