Background. While some Lessepsian species provide economic benefi ts for Mediterranean fi sheries, others cause economic losses. Lagocephalus sceleratus known as silver-cheeked toadfi sh poses a great risk to human health if consumed economic losses for fi shers by damaging their fi shing gears. This study aims to determine the socio-economic impact of silver-cheeked toadfi sh, with regards to its impact on biodiversity and socio-economic factors for small-scale fi sheries. Materials and methods. Face-to-face interviews were completed with a total of 261 fi shers from Izmir in the Middle Aegean region to Hatay in the Eastern Mediterranean region, to determine the problems arising from the presence of silver-cheeked toadfi sh species in the ecosystem and the resulting associated economic losses for a 1-year from 1 January to 30 December 2011. The elements, which should be taken into account in calculating silver-cheeked toadfi sh related economic losses, are related to fi shing gear, labour and the associated losses in catches. However, losses associated with silver-cheeked toadfi sh predation were beyond the scope of this study. Results. Almost all fi shers (91%) agree that silver-cheeked toadfi sh is a major problem, 82% believe that silver -cheeked toadfi sh negatively affects biodiversity, and 89% believe it lowers effi ciency of their catches. Calculated silver-cheeked toadfi sh related losses were: 1300 TRY ** (≈442 EUR) per year, per fi sherman; 263 296 TRY (≈89 521 EUR) per year, in total, for the interviewed fi shers (261), and 204 fi shers suffered economic losses relating to this species; which caused total losses of 6 033 577 TRY (≈2 051 416 EUR) per year in total for the 4719 fi shers, which were 78% of all fi shers (6051) in the study area. Two-thirds of the study respondents think that the most effective way to battle this problem would be to try to eliminate this species from Turkish waters. Among them, 32% of the fi shers believe the most suitable gear to eliminate L. sceleratus from the marine ecosystem is the purse seine and 61% consent to fi sh L. sceleratus for 4 TRY each as a target species. Conclusion. To start a bounty system and a premium payment for each pufferfi sh caught will both help to reduce negative impact of the species on the ecosystem and provide an extra income for the fi shers.