The application of synchrotron radiation to non-invasive angiography

Hughes, E. B.; Zeman, Herbert; Campbell, L. E.; Hofstadter, R.; Meyer‐Berkhout, U.; Otis, J. N.; Rolfe, J.; Stone, Jon R.; Wilson, S. L.; Rubenstein, Edward; Harrison, Donald C.; Kernoff, Robert S.; Thompson, Alison; Brown, G. S.

doi:10.1016/0167-5087(83)91202-4

Cited by 31 publications

(5 citation statements)

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“…A c c e p t e d M a n u s c r i p t injection (Hughes et al 1983). The same type of study was also carried out for a fixed iodine concentration c CM = 10 mg/ml and varying the vessel diameter between 0.2 mm and 6 mm.…”

Section: Study Of the Snr In A Phantommentioning

confidence: 99%

Inverse Compton radiation: a novel x-ray source for K-edge subtraction angiography?

Paternò¹,

Cardarelli²,

Gambaccini³

et al. 2019

Phys. Med. Biol.

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Coronary angiography is clinically used worldwide to diagnose diseases of coronary arteries. Despite its effectiveness, this technique is quite invasive and it is associated to significant risks due to the arterial catheterisation needed to inject the contrast agent. A valid alternative is using the K-edge subtraction method, which is based on the subtraction of two images acquired at energies bracketing the K-edge of the contrast element. The enhanced sensitivity of K-edge subtraction allows the intravenous injection of the contrast agent, thus reducing the risks of catheterisation.This technique can be effectively implemented by using intense and quasi-monochromatic X-ray beams. Synchrotron radiation has been proven to work well for this purpose, but its cost and size prevent a widespread clinical application. Inverse Compton sources are among the most promising innovative sources of intense and quasi-monochromatic X-rays. These sources are intrinsically more compact than those based on synchrotron radiation. In this work, the potential application of inverse Compton radiation to K-edge subtraction angiography is investigated. To this purpose, after a short review of the physics behind the inverse Compton process, an analytical framework is described. The proposed model is based on the application of the K-edge subtraction algorithm to calculate the SN R of details inside a suitable mathematical phantom. That allowed us to identify the characteristics of an inverse Compton source required for K-edge subtraction imaging. In particular, it was estimated that a photon fluence of 10 8 ph mm −2 is necessary to detect signals of clinical interest. Novel sources based on inverse Compton promise to achieve this requirement with an acquisition time of few hundreds of ms. This feature, together with compactness, broad two-dimensional radiation field, absence of harmonic contamination and the ability to deliver high photon fluxes also at high energies, makes this kind of sources promising for K-edge subtraction angiography and other diagnostic applications.

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Section: Study Of the Snr In A Phantommentioning

confidence: 99%

Inverse Compton radiation: a novel x-ray source for K-edge subtraction angiography?

Paternò¹,

Cardarelli²,

Gambaccini³

et al. 2019

Phys. Med. Biol.

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show abstract

“…The detector and imaging system was identical to that used in an evaluation of the use of synchrotron radiation for non-invasive angiography. Results with this system have been presented by Hughes et al [6].…”

Section: Experimental Resul1smentioning

confidence: 86%

Computed tomography using synchrotron radiation

Thompson

Llacer

Finman

et al. 1984

Nuclear Instruments and Methods in Physics Research

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“…Digital-subtraction angiography with synchrotron radiation requires a one-dimensional detector with many elements to measure the flux transmitted through a sample as a function of position. The silicon detector used for this technique illustrates how a silicon multi-element detector can be used with synchrotron radiation to measure high fluxes with excellent linearity and stability [6,14].…”

Section: Applicationsmentioning

confidence: 99%

“…LBL is currently fabricating a silicon lithium-drifted detector which will have an active volume 150 mm long, 3 mm wide and 5 mm thick, consisting of a linear array of 300 elements.· Each element will be 0.4 mm by'3 mm and have a center-to-center spacing of 0.5 mm. The detector will be used with 300 separate channels of readout electronics in an experiment evaluating the application of synchrotron radiation for digital angiography [ 6].…”

mentioning

confidence: 99%