Objective. To investigate the effects of a functional exercise program based on Proprioceptive Neuromuscular Facilitation techniques (PNF) on muscle strength and functional activities in a patient with inclusion body myositis (IBM) associated with human immunodeficiency virus (HIV) infection. Method. A patient with IBM was tested for muscle strength and functional capacities before and after a 16-week, patient-specific, home-based exercise program involving mild, daily and functional exercises. Results. Although real benefits of muscular force have been achieved, functional independence level was not modified. We believe the physical rehabilitation program served for minimization of the complications generated by the muscular weakness and optimization of motor abilities. Conclusion. The findings of this study indicate that an individually prescribed home exercise program, based on PNF techniques, can be safely implemented, since it respects the particularities of the patients and the disease, and is therefore beneficial in the management of patients with IBM, especially associated with HIV infection.