Background: Chronic Kidney Disease (CKD) is a worldwide health threat. The Pyramids of Egypt are one of the world's most amazing achievements. Thereby, the present study aims to investigate the ameliorative efficacy of housing Unilateral Nephrectomized (UNx) rats inside model of the great Egyptian pyramid.Results: Housing UNx rats for 24 and 48h inside the Egyptian pyramid model induced significant increase in the weight of the right kidney, serum sodium and calcium levels and potassium ions excretion in urine. Creatinine clearance increased significantly after housing UNx rats inside the Egyptian pyramid model following 48 h. However, housing of rats inside the Egyptian pyramids for 24 and 48h ameliorate kidney function markers (proteinuria, urea and uric acid) and restore their levels towards the control values. In addition, levels of the reinin, angiotensin and aldosterone hormones significantly increased after housing UNx rats inside the Egyptian pyramid for 24 and 48h.
Conclusion:The present study showed that housing nephrectomized rats inside model of the Egyptian pyramid may be a potential new strategy prevents CKD following renal tumour resection. Also, the current study suggested that pyramid environment plays an important role in ameliorating the serious effects of nephrectomy by enhancing kidney function.