Developing Green Building (GB) is one of the most effective measures to save energy and reduce carbon emissions in the world. To promote the development of green building, it is necessary to analyze driving factors and contribution through the analysis for relationship between regional economy and green building. Therefore, based on the system dynamic(SD) theory, this paper constructs the structure model of the stock flow diagram, including the regional economic subsystem, social subsystem, government support subsystem and green building subsystem. Among the model, Guangdong province, as the most prosperous province of economic development with the largest numbers of certified green buildings in China, has been chosen to show the influence level of their relationship. Through simulation, results can be easily shown that development of GB can make contributions to the field of local economy, however, also be limited by the regional condition, including policy incentive, regional economic, technological, etc. We can also find that direct contribution to the GDP the Green Building made can reach about 2.47 ‰, and 9.23 ‰ indirectly. If the current level of regional production is stable, it can be found that each additional 10,000 square meters of green area building may produce about ¥018.2 million for economy. On the contrary, that the regional economy investment in fixed assets increased by ¥1 million can stimulate 0.001648 million square meter demand of GB. Additionally, employment opportunities directly or indirectly have also been considered.