The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics

Zheng, Mengli; Liu, Yating; Zhang, Guanfeng; Yang, Zhikang; Xu, Weiwei; Chen, Qinghua

doi:10.3390/antiox12091675

Cited by 69 publications

(17 citation statements)

References 114 publications

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“…Age and gender were responsible for the majority of AK variance (15%), while the three significant SNPs IRF4, MC1R, and TYR collectively accounted for 2.6%. These findings align with those commonly observed in genome-wide association studies of complex human systems ( 38 – 40 ).…”

Section: Mutagenesissupporting

confidence: 90%

Advancements in elucidating the pathogenesis of actinic keratosis: present state and future prospects

Wang,

Shi

et al. 2024

Front. Med.

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Solar keratosis, also known as actinic keratosis (AK), is becoming increasingly prevalent. It is a benign tumor that develops in the epidermis. Individuals with AK typically exhibit irregular, red, scaly bumps or patches as a result of prolonged exposure to UV rays. These growths primarily appear on sun-exposed areas of the skin such as the face, scalp, and hands. Presently, dermatologists are actively studying AK due to its rising incidence rate in the United States. However, the underlying causes of AK remain poorly understood. Previous research has indicated that the onset of AK involves various mechanisms including UV ray-induced inflammation, oxidative stress, complex mutagenesis, resulting immunosuppression, inhibited apoptosis, dysregulated cell cycle, altered cell proliferation, tissue remodeling, and human papillomavirus (HPV) infection. AK can develop in three ways: spontaneous regression, persistence, or progression into invasive cutaneous squamous cell carcinoma (cSCC). Multiple risk factors and diverse signaling pathways collectively contribute to its complex pathogenesis. To mitigate the risk of cancerous changes associated with long-term UV radiation exposure, prompt identification, management, and prevention of AK are crucial. The objective of this review is to elucidate the primary mechanisms underlying AK malignancy and identify potential treatment targets for dermatologists in clinical settings.

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Section: Mutagenesissupporting

confidence: 90%

Advancements in elucidating the pathogenesis of actinic keratosis: present state and future prospects

Wang,

Shi

et al. 2024

Front. Med.

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“…However, an animal's antioxidant defense system is integral to its health. The primary roles of GSH-Px and SOD are to eliminate free radicals (Song and Shen, 2020 ; Zheng et al, 2023 ). Malondialdehyde, a byproduct of lipid peroxidation in cells, can damage cell membrane structure and function (Meng et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Regulation of the growth performance and the gastrointestinal microbiota community by the addition of defective pear fermentation to feed of small-tailed Han sheep

Peng,

Chen,

Guo

et al. 2024

Front. Microbiol.

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This study investigated the effects of defective pear fermentation (DPF) diets on growth performance and gastrointestinal microbial communities in 60 healthy male small-tailed Han sheep, aged 90 days. The sheep were randomly divided into four groups, each consisting of three replicates with five sheep per replicate. Initially, all groups received a basal diet for seven days during the adaptation stage. Subsequently, for 60 days, group C (control) was fed a basal diet, group X received a basal diet with 2% DPF, group Y had a basal diet with 4% DPF, and group Z was fed a basal diet with 6% DPF. The results indicated that group Y experienced a significant increase in average daily gain (ADG) and average daily feed intake (ADFI). The addition of DPF significantly elevated the levels of GSH-Px and notably reduced MDA content compared to group C. Analysis of gastrointestinal microbiota showed that groups receiving DPF had increased relative abundances of Lachnospiraceae_NK3A20_group, norank_f p-2534-18B5_gut_group, Acetitomaculum, Actinobacteriota, Bacteroidota and Ruminococcus_gauvreauii_group, and decreased abundances of Proteobacteria, Prevotella, Staphylococcus, and Psychrobacter compared to group C. Group X exhibited the highest relative abundance of Olsenella, while group Y showed a significant increase in unclassified_f Lachnospiraceae compared to the other groups. Bacterial function prediction indicated that pathways related to energy metabolism were more prevalent in group X and Y. This study preliminarily confirms the feasibility of using DPF as feed additives, providing a foundation for further research and evaluation of DPF's application in animal production.

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“…Therefore, its level in the cell should be strictly regulated. 224,225 ROS are utilized in the activation of numerous signaling pathways and transcription factors, such as PI3K (phosphoinositide 3-kinase)/AKT, MAPK, NRF2 (nuclear factor erythroidderived 2-like 2)/KEAP1 (Kelch like-ECH-associated protein 1), NF-κB, and p53, which, in turn, can promote cell death or survival. 220 When the level of ROS considerably surpasses the neutralizing ability of the antioxidant systems, the resulting oxidative stress causes significant cellular damage.…”

Section: •−mentioning

confidence: 99%

“…Though moderately reactive by itself, O 2 •– can participate in various reactions, producing a number of ROS and reactive nitrogen species (RNS). Therefore, its level in the cell should be strictly regulated. , …”

Section: Mechanisms Of Biological Activity Of Ionic Liquids: State Of...mentioning

confidence: 99%

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Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Egorova,

Kibardin,

Posvyatenko

et al. 2024

Chem. Rev.

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The review presents a detailed discussion of the evolving field studying interactions between ionic liquids (ILs) and biological systems. Originating from molten salt electrolytes to present multiapplication substances, ILs have found usage across various fields due to their exceptional physicochemical properties, including excellent tunability. However, their interactions with biological systems and potential influence on living organisms remain largely unexplored. This review examines the cytotoxic effects of ILs on cell cultures, biomolecules, and vertebrate and invertebrate organisms. Our understanding of IL toxicity, while growing in recent years, is yet nascent. The established findings include correlations between harmful effects of ILs and their ability to disturb cellular membranes, their potential to trigger oxidative stress in cells, and their ability to cause cell death via apoptosis. Future research directions proposed in the review include studying the distribution of various ILs within cellular compartments and organelles, investigating metabolic transformations of ILs in cells and organisms, detailed analysis of IL effects on proteins involved in oxidative stress and apoptosis, correlation studies between IL doses, exposure times and resulting adverse effects, and examination of effects of subtoxic concentrations of ILs on various biological objects. This review aims to serve as a critical analysis of the current body of knowledge on IL-related toxicity mechanisms. Furthermore, it can guide researchers toward the design of less toxic ILs and the informed use of ILs in drug development and medicine.

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The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics

Cited by 69 publications

References 114 publications

Advancements in elucidating the pathogenesis of actinic keratosis: present state and future prospects

Advancements in elucidating the pathogenesis of actinic keratosis: present state and future prospects

Regulation of the growth performance and the gastrointestinal microbiota community by the addition of defective pear fermentation to feed of small-tailed Han sheep

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

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