The Applications of Acetone and Ethyl Acetate

Wan, Jie‐Ping

doi:10.1002/9783527805624.ch5

Cited by 3 publications

(4 citation statements)

References 133 publications

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“…Initially, docetaxel-glutarate was synthesized, brie y, equvmolar concentration of-docetaxel, glutaric anhydride, and pyridine was dissolved in 5 ml DMSO (as solvent) and stirred for 48hr at room temperature to form docetaxel-glutarate (docetaxel-COOH). After 48 hrs reaction solution was washed three times with 50 ml of deionized water: ethyl acetate, to remove unreacted glutaric anhydride, pyridine and the organic phase (ethyl acetate) with docetaxel-glutarate (docetaxel-COOH) was collected and lyophilized for FTIR and 1 H-NMR characterization as shown in Figure 1B (20).…”

Section: Synthesizing Carboxyl Functional Group (-Cooh) On Docetaxelmentioning

confidence: 99%

Discovering the antitumor potential of a novel PDC of HSP70-TAA complex with Docetaxel for sustained and prolonged release of docetaxel to increase its efficacy and reduce drug resistance in OSCC

Singh,

Gautam,

Verma

et al. 2023

Preprint

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Background: Heat shock protein 70 (HSP70) overexpression has been reported in a variety of cancers. HSP70 is transported to the cell surface and released into the environment, where it is taken up by antigen-presenting cells and presented to lymphocytes for an immunological response. In previous investigations, we extensively studied HSP70's immunotherapeutic potential against cancer. Cancer is a fatal disease, and chemotherapy drugs have been shown to be effective against several types of cancer. Several attempts have been made to improve chemotherapeutic drugs target delivery while limiting adverse effects. With the aim to minimizing off-site cytotoxicity without impairing docetaxel function in cancer cells, we established the PrDC of HSP70 isolated from cancer cells with the chemotherapy drug docetaxel, to target tumor heterogeneity and, enhance target delivery Methodology: HSP70 isolated from cancer cells was purified using size exclusion chromatography and immunoprecipitation. To conjugate docetaxel with the primary amine groups on HSP70, a cleavable ester bond with the carboxyl group was established while preserving the structural integrity of docetaxel. The purity of HSP70 was evaluate by western blotting (WB), while NMR, FTIR, and WB were used to identify the purity of docetaxel and final conjugate. Docetaxel release from the conjugate was investigated in-vitro in four distinct buffers that replicated human philological conditions. The anticancer efficacy of docetaxel, both in combination and alone, was assessed on squamous cell carcinoma cells using the MTT, ICC, cell cycle, apoptosis, multi-drug resistance, and mitochondrial mass assay. Results: The findings show that the conjugate of docetaxel and HSP70 has a stoichiometric ratio of 30:1. In SCC cells, docetaxel's extended release (120 hours) was correlated with a 13±2-fold rise in efficacy. Additionally, the results showed that DHSP decreases multi-drug resistance and mitochondrial mass in SCC cells while halting cells in the G2 phase of the cell cycle for an extended period of time (72 hours), which is followed by apoptosis. Conclusions: The docetaxel-HSP70 conjunction has the potential to enhance target drug delivery and drug retention in cancer cells while lowering off-site cytotoxicity. It additionally improves docetaxel effectiveness for longer periods of time at 13–15 times lower dosages.

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Section: Synthesizing Carboxyl Functional Group (-Cooh) On Docetaxelmentioning

confidence: 99%

Discovering the antitumor potential of a novel PDC of HSP70-TAA complex with Docetaxel for sustained and prolonged release of docetaxel to increase its efficacy and reduce drug resistance in OSCC

Singh,

Gautam,

Verma

et al. 2023

Preprint

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“…Due to its properties, such as the ability to dissolve and low toxicity, ethyl acetate has a wide range of applications across many industries such as food and beverages, pharmaceuticals, packaging, and so on 27,28 . Ethyl acetate is the most well‐known and frequently used organic solvent in chromatography and extractions 30 . It has been used in mobile phases for normal‐phase HPLC to facilitate separation processes 31 .…”

Section: Introductionmentioning

confidence: 99%

Concentration dependency of dispersion coefficient of aqueous solutions of urea and ethyl acetate in porous media

2022

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We report new measurements of the concentration-dependent longitudinal dispersion coefficient of aqueous urea and ethyl acetate solutions in a porous medium at a wide range of concentrations. The longitudinal dispersion coefficient was obtained by injection of a pulse of an aqueous solution of urea (or ethyl acetate) into a carrier phase flowing through a porous column and analysis of the effluent peak using the Taylor dispersion theory. The measured longitudinal dispersion coefficients for different velocities and concentrations showed an increasing trend with concentration and pore velocity. The longitudinal dispersion coefficient measurements show a powerlaw relationship with the Peclet number K L / α l Pe β l m À Á . The results are compared with experimental data and empirical formulas available in the literature, and a reasonable agreement is achieved over the range of Peclet numbers studied.

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“…3,6 The reader is referred to the excellent book chapter by Reichardt and Welton 6 for an inclusive summary of the different categories and types of solvents. Although the consumption of solvents from the different categories significantly varies in terms of geographical area, industrial sector and application, still, a general industry preference exists toward polar solvents owing to their high reactivity 7 and unique physical and chemical properties making them viable solvents for product separation and extraction. 8 From a molecular viewpoint, the key common attribute between these polar solvents, protic and aprotic, is the presence of a permanent dipole moment, which is responsible for inducing complex and nonideal thermodynamic behaviors.…”

Section: Introductionmentioning

confidence: 99%

“…The dipolar fluids examined in this work include 1-hexene, chloroform, dichloromethane, tetrahydrofuran, acetone, dimethylformamide (DMF), and N-methyl pyrrolidone (NMP). These fluids have been chosen for practical reasons given their wide industrial applications, being almost industry standards for a wide range of applications 2,3,7,45 as well as more fundamental reasons, as they present a variable range of dipole moment from low to high (0.3 < μ < 4.0 D) that allows to effectively test the limits of our simplified modeling approach for polar fluids, 34 and the variety in their polar strength leads to varying phase equilibria behavior, VLE and LLE, when extended to binary mixtures with n-alkanes. Overall, it is intended to assess the validity of our simplified modeling approach and to test the predictive capability and robustness of polar soft-SAFT for these challenging mixtures.…”

Section: Introductionmentioning

confidence: 99%

Quantifying the effect of polarity on the behavior of mixtures of n‐alkanes with dipolar solvents using polar soft‐statistical associating fluid theory (Polar soft‐SAFT)

Alkhatib

Vega

2020

AIChE Journal

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We present results concerning the phase equilibria and excess properties of binary mixtures of n-alkanes with a range of fluids from low to high dipolar strength, namely 1-hexene, chloroform, dichloromethane, tetrahydrofuran, acetone, dimethylformamide, and N-methyl pyrrolidone modeled by polar soft-statistical associating fluid theory. Polar interactions are considered through the theory of Gubbins and Twu, extended to chainlike fluids by Jog and Chapman, and a priori fixing the polar parameters of the pure fluids, instead of fitting to experimental data. The equation provides accurate predictions for low to moderate dipolar molecules with n-alkanes, while the induced dipoles created by very strong dipolar fluids (μ ≥ 3.5 D), is implicitly considered by the appropriate selection of pure component parameters and a binary parameter which can be transferred to predict other properties. The equation is used to systematically study the effect of asymmetrical energy scales between polar and nonpolar fluids on vapor-liquid equilibria and excess properties.

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The Applications of Acetone and Ethyl Acetate

Cited by 3 publications

References 133 publications

Discovering the antitumor potential of a novel PDC of HSP70-TAA complex with Docetaxel for sustained and prolonged release of docetaxel to increase its efficacy and reduce drug resistance in OSCC

Discovering the antitumor potential of a novel PDC of HSP70-TAA complex with Docetaxel for sustained and prolonged release of docetaxel to increase its efficacy and reduce drug resistance in OSCC

Concentration dependency of dispersion coefficient of aqueous solutions of urea and ethyl acetate in porous media

Quantifying the effect of polarity on the behavior of mixtures of n‐alkanes with dipolar solvents using polar soft‐statistical associating fluid theory (Polar soft‐SAFT)

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