The Applications of Focused Ultrasound (FUS) in Alzheimer’s Disease Treatment: A Systematic Review on Both Animal and Human Studies

Liu, Xiaodan; Naomi, S Sta Maria; Sharon, Wu Lin; Russell, Edith

doi:10.14336/ad.2021.0510

Cited by 31 publications

(24 citation statements)

References 76 publications

(184 reference statements)

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“…The applications of focused ultrasound have been increasing, and diagnostic ultrasound has been established as a critical clinical imaging modality (Trockel et al, 1984;Fu et al, 2015;Nainwal, 2017;Darrow, 2019;di Biase et al, 2021;Liu et al, 2021). TFUS is a non-invasive technology that can be used to monitor cerebral circulation (Thomassen et al, 2021).…”

Section: Transcranial Focused Ultrasound Stimulation Technology and P...mentioning

confidence: 99%

Transcranial ultrasound stimulation applied in ischemic stroke rehabilitation: A review

et al. 2022

Front. Neurosci.

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Ischemic stroke is a serious medical condition that is caused by cerebral vascular occlusion and leads to neurological dysfunction. After stroke, patients suffer from long-term sensory, motor and cognitive impairment. Non-invasive neuromodulation technology has been widely studied in the field of stroke rehabilitation. Transcranial ultrasound stimulation (TUS), as a safe and non-invasive technique with deep penetration ability and a tiny focus, is an emerging technology. It can produce mechanical and thermal effects by delivering sound waves to brain tissue that can induce the production of neurotrophic factors (NFs) in the brain, and reduce cell apoptosis and the inflammatory response. TUS, which involves application of an acoustic wave, can also dissolve blood clots and be used to deliver therapeutic drugs to the ischemic region. TUS has great potential in the treatment of ischemic stroke. Future advancements in imaging and parameter optimization will improve the safety and efficacy of this technology in the treatment of ischemic stroke.

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Section: Transcranial Focused Ultrasound Stimulation Technology and P...mentioning

confidence: 99%

Transcranial ultrasound stimulation applied in ischemic stroke rehabilitation: A review

et al. 2022

Front. Neurosci.

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“…Es wird vermutet, dass dies bei der Gabe von Arzneimitteln deren Wirksamkeit steigern könnte. Bei Patientinnen und Patienten mit AD gibt es noch keine Untersuchungen, die den Einsatz von microbubbles in Kombination mit Antidementiva untersuchten [27].…”

Section: Transkranielle Pulsstimulationunclassified

Stimulationsverfahren zur Behandlung von Demenzen

Fassbender

Goedecke

Visser‐Vandewalle

et al. 2022

Fortschr Neurol Psychiatr

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ZusammenfassungAufgrund steigender Fallzahlen der Alzheimer-Erkrankung und bislang eher mäßigem Erfolg der verfügbaren symptomatischen und kausalen pharmakologischen Therapien besteht ein erheblicher Bedarf, nicht-pharmakologische Behandlungsmöglichkeiten zu erforschen. Im Bereich der nicht-invasiven Hirnstimulation (non-invasive brain stimulation; NIBS) wurden verschiedene Verfahren untersucht, insbesondere die transkranielle Magnetstimulation und die transkranielle elektrische Stimulation. Zusätzlich wird derzeit die Tiefe Hirnstimulation (deep brain stimulation; DBS) als innovatives Verfahren zur gezielten Neuromodulation erforscht. Nicht-invasiven und invasiven Ansätzen gemein ist der Versuch, neuronale Aktivität zu modulieren und kognitiv-mnestische Funktionen zu verbessern. Durch sekundäre Mechanismen wie die Langzeit-Potenzierung bei NIBS oder Neurogenese bei DBS könnten auch längerfristige positive Effekte erzielt werden. Präklinische und klinische Studien ergaben bereits vielversprechende Ergebnisse bei Patientinnen und Patienten in frühen Stadien der Alzheimer-Erkrankung. Inkonsistente Studien- und Stimulationsprotokolle sowie kleine Stichproben erschweren jedoch die Bewertung der Wirksamkeit. Weitere Forschungsbemühungen sind angebracht, um einen zeitnahen Einzug nicht-invasiver oder invasiver neuromodulatorischer Ansätze in die klinische Praxis zu ermöglichen.

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“…Patients recruited in those studies generally fulfilled the criteria for mild to moderate AD ( Lipsman et al, 2018 ; Meng et al, 2019 ; Beisteiner and Lozano, 2020 ), one study targeted early AD patients ( Rezai et al, 2020 ), another patient with PD ( Nicodemus et al, 2019 ) or PD dementia ( Gasca-Salas et al, 2021 ). Although increased BBB permeability was always detected in the targeted regions along with sparse evidence of reduction in Aβ deposition ( Park et al, 2021 ), the clinically meaningful impact of such changes is still questionable (reviewed by Liu et al, 2021 ) and a sensitive target subpopulation remains elusive.…”

Section: Improving Drug Delivery and Target Engagement In Nds: The Pr...mentioning

confidence: 99%

Exploiting Focused Ultrasound to Aid Intranasal Drug Delivery for Brain Therapy

2022

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Novel effective therapeutic strategies are needed to treat brain neurodegenerative diseases and to improve the quality of life of patients affected by Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), Amyotrophic Lateral sclerosis (ALS) as well as other brain conditions. At present no effective treatment options are available; current therapeutics for neurodegenerative diseases (NDs) improve cognitive symptoms only transiently and in a minor number of patients. Further, most of the amyloid-based phase III clinical trials recently failed in AD, in spite of promising preclinical and phase I-II clinical trials, further pinpointing the need for a better knowledge of the early mechanisms of disease as well as of more effective routes of drug administration. In fact, beyond common pathological events and molecular substrates, each of these diseases preferentially affect defined subpopulations of neurons in specific neuronal circuits (selective neuronal vulnerability), leading to the typical age-related clinical profile. In this perspective, key to successful drug discovery is a robust and reproducible biological validation of potential new molecular targets together with a concomitant set up of protocols/tools for efficient and targeted brain delivery to a specific area of interest. Here we propose and discuss Focused UltraSound aided drug administration as a specific and novel technical approach to achieve optimal concentration of the drug at the target area of interest. We will focus on drug delivery to the brain through the nasal route coupled to FUS as a promising approach to achieve neuroprotection and rescue of cognitive decline in several NDs.

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The Applications of Focused Ultrasound (FUS) in Alzheimer’s Disease Treatment: A Systematic Review on Both Animal and Human Studies

Cited by 31 publications

References 76 publications

Transcranial ultrasound stimulation applied in ischemic stroke rehabilitation: A review

Transcranial ultrasound stimulation applied in ischemic stroke rehabilitation: A review

Stimulationsverfahren zur Behandlung von Demenzen

Exploiting Focused Ultrasound to Aid Intranasal Drug Delivery for Brain Therapy

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