The applications of nanozymes in cancer therapy: based on regulating pyroptosis, ferroptosis and autophagy of tumor cells

Zhang, Yuan; Yu, Wanpeng; Chen, Mengmeng; Zhang, Bingqiang; Zhang, Lei; Li, Peifeng

doi:10.1039/d3nr01722b

Cited by 27 publications

(10 citation statements)

References 103 publications

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“…Additionally, some nanozymes can consume glucose, inducing death by starvation. 72 Additionally, nanozymes with oxidoreductase-mimicking activity offer the combined advantages of nanomaterials and natural enzymes. They demonstrate high catalytic activity and excellent catalytic stability, even under harsh conditions, surpassing the capabilities of natural enzymes.…”

Section: Biomedical Applications Of Nir-ii Cdsmentioning

confidence: 99%

“…Nanozymes have the capability to induce changes in ROS levels and activate inflammasomes, leading to pyroptosis, ferroptosis, and autophagy in tumor cells. Additionally, some nanozymes can consume glucose, inducing death by starvation . Additionally, nanozymes with oxidoreductase-mimicking activity offer the combined advantages of nanomaterials and natural enzymes.…”

Section: Biomedical Applications Of Nir-ii Cdsmentioning

confidence: 99%

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Recent Progress on Second Near-Infrared Emitting Carbon Dots in Biomedicine

Yang,

Han,

Bianco

et al. 2024

ACS Nano

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Second near-infrared (NIR-II) carbon dots, with absorption or emission between 1000 and 1700 nm, are gaining increasing attention in the biomaterial field due to their distinctive properties, which include straightforward preparation processes, stable photophysical characteristics, excellent biocompatibility, and low cost. As a result, there is a growing focus on the controlled synthesis and modulation of the photochemical and photophysical properties of NIR-II carbon dots, with the aim to further expand their biomedical applications, a current research hotspot. This account aims to provide a comprehensive overview of the recent advancements in NIR-II carbon dots within the biomedical field. The review will cover the following topics: (i) the design, synthesis, and purification of NIR-II carbon dots, (ii) the surface modification strategies, and (iii) the biomedical applications, particularly in the domain of cancer theranostics. Additionally, this account addresses the challenges encountered by NIR-II carbon dots and will outline future directions in the realm of cancer theranostics. By exploring carbon-based NIR-II biomaterials, we can anticipate that this contribution will garner increased attention and contribute to the development of next-generation advanced functional carbon dots, thereby offering enhanced tools and strategies in the biomedical field.

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Section: Biomedical Applications Of Nir-ii Cdsmentioning

confidence: 99%

Section: Biomedical Applications Of Nir-ii Cdsmentioning

confidence: 99%

Recent Progress on Second Near-Infrared Emitting Carbon Dots in Biomedicine

Yang,

Han,

Bianco

et al. 2024

ACS Nano

View full text Add to dashboard Cite

show abstract

“…This success of the tumor treatment model is attributed to the physical induction of pyroptosis, which activates the tumor destruction mechanism. Particle effects triggered by physical stimuli such as sound, light and electricity combined with pyroptosis will help to promote the progress of tumor treatment ( 87 ). Except for the physical excitation mode in cancer, the creation of chemically induced cell pores is also relatively common ( 88 ).…”

Section: Strategies Of Pyroptosis In Cancer Therapymentioning

confidence: 99%

Application of pyroptosis in tumor research (Review)

Tan

Zhou

2023

Oncol Lett

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As a potent clinical strategy, cancer therapy has sparked an academic boom over the past few years. Immune checkpoint inhibitors (ICIs) have been demonstrated to be highly successful. These achievements have progressed cancer treatment and have made an indelible mark on cancer. However, the inherent complexity of cancer means that only part of the population can benefit from this treatment. Pyroptosis is a new suicidal cellular mechanism that induces inflammation by releasing immunogenic cellular components. Inflammatory signaling cascades mediated by pyroptosis commonly inspire numerous cell lysis in immune diseases. Contrariwise, this consequence may be a promising target in cancer research. Therefore, the present study briefly described programmed cell death processes and their potential roles in cancer. Because of the rapid development of bioengineering in cancer, the present study also examined the associated scaffolding available for cancer, highlighting advances in tumor engineering approaches. Ultimately, an improved understanding of pyroptosis and tumor scaffolding might shed light on a combination that can be manipulated for therapeutic purposes.

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“…In recent years, nanocarrier technology has developed rapidly and has been effective in improving the pharmacokinetics and bioavailability of drugs. 7 , 8 Nanocarrier technology can realize the effective encapsulation and delivery of adjuvants and antigens, improve antigen stability and increase antigen loading, and provide the possibility for multiple routes of vaccination (such as oral administration, inhalation delivery, etc.).…”

Section: Introductionmentioning

confidence: 99%

The Application of Nanovaccines in Autoimmune Diseases

Tang,

2024

IJN

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Autoimmune diseases are diseases caused by the body’s chronic immune responses to self-antigens and attacks on the host’s own cells, tissues and organs. The dysfunction of innate immunity and adaptive immunity leads to the destruction of autoimmune tolerance, which is the most basic factor leading to pathogenesis. The optimal strategy for autoimmune diseases is to modify the host immune system to restore tolerance. The ideal effect of therapeutic autoimmune diseases is to eliminate the autoantigen-specific spontaneous immune response without interfering with the immune response against other antigens. Therapeutic nanovaccines that produce immune tolerance conform to this principle. Nanomaterials provide a platform for antigen loading and modification due to their unique physical and chemical properties. Nanovaccines based on nanomaterial technology can simultaneously enable antigens and adjuvants to be absorbed by immune cells and induce rapid and durable immunity. Nanovaccines have the advantages of being able to be designed and loaded and of better protecting antigens from premature degradation. Nanovaccines also have the ability to target specific tissues or cells through optimized design. We review the latest research progress of nanovaccines for autoimmune diseases and the design strategies of nanovaccines to promote the development of more effective nanovaccines for autoimmune diseases.

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The applications of nanozymes in cancer therapy: based on regulating pyroptosis, ferroptosis and autophagy of tumor cells

Abstract: Nanozymes are nanomaterials with catalytic properties similar to those of natural enzymes, and they have recently been collectively identified as a class of innovative artificial enzymes.

Cited by 27 publications

References 103 publications

Recent Progress on Second Near-Infrared Emitting Carbon Dots in Biomedicine

Recent Progress on Second Near-Infrared Emitting Carbon Dots in Biomedicine

Application of pyroptosis in tumor research (Review)

The Application of Nanovaccines in Autoimmune Diseases

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