The Applications of Nitromethane as Reagent and Solvent in Organic Synthesis

Sc(OTf)3-Catalyzed Synthesis of Symmetrical Dithioacetals and Bisarylmethanes Using Nitromethane as a Methylene Source

“…Nitromethane is the simplest nitro compound, often used as a solvent, reagent, stabilizer, and fuel in motor sports and rockets . In organic synthesis, owing to its strongly electron-withdrawing nature, nitromethane has served as pronucleophile to access a wide range of useful compounds such as nitroalkenes, β-nitroalcohols (Henry reaction), amines, and carbonyl compounds (Michael addition) (Scheme , B) . The reactivity of nitromethane as a nitrogen donor was recently explored by Jiao and co-workers in their Schmidt-type synthesis of amides and nitriles (Scheme , B) .…”