The applied anatomy of thyroglossal tract remnants

Ellis, Peter; Nostrand, A. W. P. Van

doi:10.1002/lary.5540870512

Cited by 203 publications

(123 citation statements)

References 4 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…The exact incidence of thyroglossal duct remnants is unknown. Microscopic examination of 200 adult larynges reported by Ellis and van Nostrand showed thyroglossal duct remnants in 7 % of specimens [21], while an autopsy study involving 58 pediatric patients identified remnants of the thyroglossal duct or ectopic thyroid tissue in 41 % of cases [17]. Clinical manifestation of TGDC based on a mid-year mean patient population of 3,064,661 patients for Southern California Permanente Medical Group would correspond to 2.23/100,000 population at risk each year.…”

Section: Discussionmentioning

confidence: 91%

A Clinicopathologic Series of 685 Thyroglossal Duct Remnant Cysts

Thompson¹,

Herrera²,

Lau³

2016

Head and Neck Pathol

110

104

View full text Add to dashboard Cite

The clinical features of thyroglossal duct remnant cysts (TGDC) have been well described, however the histopathologic aspects of these lesions have not been addressed in a detailed manner. In particular, there has been no large community practice based series evaluating TGDC histologically compared with management outcomes. A retrospective review of all TGDC diagnosed between 2005 and 2015 was performed. Six hundred eighty-five patients were identified (344 males; 341 females). Age at presentation was bimodal (first and fifth decades) and ranged from 0.8 to 87 years (mean 31.3 years). Males predominate in children (150:111); females in adults (230:194). Patients presented most frequently with a mobile midline neck mass in an infrahyoid location. An associated skin fistula (n = 67) was twice as common in pediatric as adult patients. The average cyst size was 2.4 cm (range 0.4-9.9 cm) by imaging studies and 2.6 cm (range 0.2-8.5 cm) by pathologic examination; pediatric patients had smaller cysts (mean 2.1 cm) than adults (mean 2.8 cm). Histologically, 257 (38 %) TGDC were lined by respiratory epithelium alone, 68 (10 %) squamous epithelium alone, 347 (51 %) exhibited both respiratory and squamous epithelium, and 13 (1 %) had no identifiable epithelial lining. Four hundred eighty-four (71 %) TGDC had associated thyroid gland tissue present within the cyst wall (n = 282), skeletal muscle (n = 71), adipose tissue (n = 34), or a combination of these sites (n = 97). The hyoid bone was identified in 647 (grossly and/or histologically), and absent in 38. Surgical management consisted of Sistrunk procedure (n = 647), cystectomy (n = 31), or thyroidectomy/thyroid lobectomy (n = 7). Treatment related complications were observed in 6 patients, which included vocal cord damage, seroma, and hematoma. Recurrences developed in 20 (3 %) patients, 14 of whom were managed initially by cystectomy. Papillary thyroid carcinoma was identified in 22 (3.2 %) TGDC. In summary, TGDC show a bimodal peak in the 1st and 5th decades, commonly presenting as a midline cervical lesion below the hyoid bone, associated with a skin fistula in 10 %. Histologically TGDC are most commonly lined by a combination of respiratory and squamous epithelium. Thyroid gland tissue is identified in 71 % of cases (0.45 cm mean size), although not limited to the cyst wall, but present in the surrounding soft tissues. Rare TGDC may harbor malignancy (3.2 %). TGDC are most effectively managed by Sistrunk procedure rather than excision, which carries low rates of complications (1 %) and recurrence (3 %).

show abstract

Section: Discussionmentioning

confidence: 91%

A Clinicopathologic Series of 685 Thyroglossal Duct Remnant Cysts

Thompson¹,

Herrera²,

Lau³

2016

Head and Neck Pathol

110

104

View full text Add to dashboard Cite

show abstract

“…4 Cadaveric studies reveal persistent TGDC in 7% of the asymptomatic adult population. 5,6 TGDC may be found anywhere along the embryologic anlage, typically in close apposition to the hyoid bone and thyrohyoid membrane (approximately 60%-65%). 2,7 Enlargement of TGDC after an infection, or in the rare case of carcinoma within the cyst, is a well-documented phenomenon.…”

Section: Figmentioning

confidence: 99%

Enlargement and Transformation of Thyroglossal Duct Cysts in Response to Radiotherapy: Imaging Findings

Singh

Rosenthal

Ginsberg

2009

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE:Thyroglossal duct cyst remnants (TGDC) are a common midline neck mass that is mostly encountered in childhood. Enlargement after an upper respiratory tract infection or, rarely, cancer within TGDC, is a well-documented phenomenon. In the pediatric population, it rarely presents a diagnostic quandary. However, in an adult population, especially one treated for head and neck cancer with radiation therapy (RT), any enlarging cystic mass would be concerning and would raise the specter of metastatic disease. We propose that inflammation associated with RT results in secretory stimulation and/or obstruction of a persistent thyroglossal duct, resulting in changes within a pre-existing TGDC.

show abstract

“…It obliterates completely by ninth week of gestation. Up to 60% cases of thyroglossal duct cyst (TGDC) show islands of functioning thyroid follicles in its wall [1]. However, parafollicular cells are absent.…”

Section: Introductionmentioning

confidence: 99%

Papillary carcinoma arising in thyroglossal duct cyst: A rare case presentation

Arora¹,

Al-Hashimi²

2017

IJCRI

View full text Add to dashboard Cite

International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. We report a case of a 22-year-old female who was reported to have TGDC on radiology and fine needle aspiration cytology (FNAC). However, histopathological examination of TGDC postSistrunk procedure revealed an incidental presence of papillary carcinoma arising within a thyroglossal duct cyst which invaded its wall as well as involved a resection margin. Conclusion: Diagnostic procedures and management algorithm of such a case is discussed.

show abstract

The applied anatomy of thyroglossal tract remnants

Cited by 203 publications

References 4 publications

A Clinicopathologic Series of 685 Thyroglossal Duct Remnant Cysts

A Clinicopathologic Series of 685 Thyroglossal Duct Remnant Cysts

Enlargement and Transformation of Thyroglossal Duct Cysts in Response to Radiotherapy: Imaging Findings

Papillary carcinoma arising in thyroglossal duct cyst: A rare case presentation

Contact Info

Product

Resources

About