Neuromodulation has a growing role in the management of chronic pain. An international panel of experts has reviewed the evidence and issued guidance regarding the appropriate use of neurostimulation. It is understood that a patient-centric cadence of progression through the pain care algorithm must be considered. Neurostimulation may offer long-term cost savings and improved functional status without complications from long-term opioid use. Indications for consideration of neurostimulation include failed back surgery syndrome, complex regional pain syndrome, peripheral neuropathic pain, chronic peripheral ischemic pain, and refractory angina pectoris. Criteria crucial for success include appropriate patient selection and education, proper use of sterile facilities, attentive follow-up by the healthcare team, and provider training.