The Aqueous Crude Extracts of Montanoa frutescens and Montanoa grandiflora Reduce Immobility Faster Than Fluoxetine Through GABAA Receptors in Rats Forced to Swim

Rodríguez‐Landa, Juan Francisco; Cueto‐Escobedo, Jonathan; Flores-Aguilar, Luis Ángel; Rosas-Sánchez, Gilberto Uriel; Rovirosa-Hernández, María de Jesús; García-Orduña, Francisco; Carro‐Juárez, Miguel

doi:10.1177/2515690x18762953

Cited by 18 publications

(10 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…), and some metabolites from plants (Wistar rats: single doses of 1 mg/kg chrysin, i.p., Swiss albino mice: 50 and 100 mg/kg/1-21-days polyphenols, p.o.) (Lozano-Hernández et al, 2010;Rodríguez-Landa et al, 2018Amaghnouje et al, 2020a,b) significantly reduced TTI and, some of them, increased LI. Therefore, the measurement of LI, in addition to TTI, may improve the detection of antidepressant-like activity in the FST (Castagné et al, 2009).…”

Section: Changes In Dimensions Of Pools Used In the Fstmentioning

confidence: 98%

Considerations of Pool Dimensions in the Forced Swim Test in Predicting the Potential Antidepressant Activity of Drugs

Rosas-Sánchez

Germán-Ponciano

Rodríguez‐Landa

2022

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

Section: Changes In Dimensions Of Pools Used In the Fstmentioning

confidence: 98%

Considerations of Pool Dimensions in the Forced Swim Test in Predicting the Potential Antidepressant Activity of Drugs

Rosas-Sánchez

Germán-Ponciano

Rodríguez‐Landa

2022

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

“…The results are consistent with the previous studies that repeated administrations of FLX improve certain aspects of depression-like behavior and hippocampal functions ( David et al, 2009 ; Siopi et al, 2016 ). It has been shown that 21-day treatment with fluoxetine at 1 mg/kg reduce the immobility in the FST ( Contreras et al, 2001 ; Rodriguez-Landa et al, 2018 ). The behaviors such as sucrose preference and immobility in FST improved more quickly may account for using a relatively high dose of FLX in the present experiment.…”

Section: Discussionmentioning

confidence: 99%

Fluoxetine and Ketamine Reverse the Depressive but Not Anxiety Behavior Induced by Lesion of Cholinergic Neurons in the Horizontal Limb of the Diagonal Band of Broca in Male Rat

Gao

et al. 2021

Front. Behav. Neurosci.

View full text Add to dashboard Cite

The basal forebrain cholinergic system is involved in cognitive processes, but the role of the basal forebrain cholinergic system in depression is unknown. We investigated whether a lesion of cholinergic neurons in the horizontal limb of the diagonal band of Broca (HDB) produces depressive-like behavior and whether fluoxetine or ketamine inhibits such depressive-like behaviors. Here, in rats, we used 192 IgG-saporin to eliminate the cholinergic neurons of the HDB and evaluated depressive-like behaviors using a preference test for sucrose solution and the forced swimming test. Fourteen days after the injection of 192 IgG-saporin into the HDB, the rats exhibited a significantly fewer number of choline acetyltransferase positive cell density in HDB, accompanied with neuronal loss in the entire hippocampus. Meanwhile, these rats significantly reduced preference for sucrose solution, increased immobility time in the forced swimming test, reduced locomotor activity, decreased context dependent memory in fear conditioning and the time spent in the open arms of the plus-maze. A single dose of ketamine (10 mg/kg) increased the sucrose solution consumption, reduced the immobility time in the forced swim test (FST), and increased locomotor activity compared to vehicle-treated rats. Moreover, in rats that were continuously treated with fluoxetine (10 mg/kg/day for 11 days), the sucrose solution consumption increased, the immobility time in the FST decreased, and locomotor activity increased compared to vehicle-treated rats. The present results demonstrate that a lesion of HDB cholinergic neurons results in depressive-like and anxiety-like behaviors and that antidepressants such as fluoxetine or ketamine, can reverse these depressive-like behaviors but not anxiety-like behaviors, and suggest that a lesion of HDB cholinergic neurons and followed hippocampus damage may be involved in the pathogenesis of depression.

show abstract

“…The FST was originally described by Elhwuegi [14] and is one of the most widely used pharmacological tests for assessing antidepressant-like activity [15]. The animal is maintained in a rectangular pool (50 × 30 × 60 cm), filled to a 25 cm depth with water at room temperature at 22-25 • C [16]. The test is based on the assumption that the animal will swim actively in order to escape from stressful stimuli.…”

Section: Forced Swimming Testmentioning

confidence: 99%

Anxiolytic, Antidepressant-Like Proprieties and Impact on the Memory of the Hydro-Ethanolic Extract of Origanum majorana L. on Mice

et al. 2020

View full text Add to dashboard Cite

Marjoram (Origanum majorana L.) infusion has been used as folk medicine against depression and anxiety. However, no studies have been carried out yet to prove those activities scientifically. In this study, the anxiolytic, antidepressant-like effects, and memory impact of the hydro-ethanolic extracts of marjoram were evaluated in mice. The hydro-ethanolic extracts (250 and 500 mg/kg) were evaluated for their central nervous effect using six different behavioral tests such as light–dark box (LDB) and open field (OF) for anxiety, forced swim test (FST), and tail suspension test (TST) for depression, and object recognition test (ORT), Morris water maze (MWM) for the impact on memory. The experiments were realized on days 1, 7, 14, and 21 of treatments and compared with bromazepam for anxiety (1 mg/kg) and paroxetine for depression (11.5 mg/kg). The phytochemical screening was performed by HPLC, and the acute and sub-acute toxicities were performed following OCED guidelines (N°423 and 407) with biochemical parameters evaluation and histopathological analysis. Oral administration of marjoram hydro-ethanolic extract induced significant anxiolytic and antidepressant-like effects without memory impairment, increasing the exploration and time spent in the light area in the LDB test in a similar way to that of bromazepam. In the FST and TST, the extract was as effective as paroxetine (11.5 mg/kg, p.o.) in reducing immobility. The phytochemical screening showed the presence of ferulic acid, naringin, hydroxytyrosol, geraniol, and quercetin. This study approves the traditional use of this plant and encourages further investigation on its bioactive compounds.

show abstract

The Aqueous Crude Extracts of Montanoa frutescens and Montanoa grandiflora Reduce Immobility Faster Than Fluoxetine Through GABA_A Receptors in Rats Forced to Swim

Cited by 18 publications

References 66 publications

Considerations of Pool Dimensions in the Forced Swim Test in Predicting the Potential Antidepressant Activity of Drugs

Considerations of Pool Dimensions in the Forced Swim Test in Predicting the Potential Antidepressant Activity of Drugs

Fluoxetine and Ketamine Reverse the Depressive but Not Anxiety Behavior Induced by Lesion of Cholinergic Neurons in the Horizontal Limb of the Diagonal Band of Broca in Male Rat

Anxiolytic, Antidepressant-Like Proprieties and Impact on the Memory of the Hydro-Ethanolic Extract of Origanum majorana L. on Mice

Contact Info

Product

Resources

About