The aqueous extract of cinnamon bark ameliorated cisplatin-induced cytotoxicity in vero cells without compromising the anticancer efficiency of cisplatin

Elkady, Ayman I.; Ramadan, Wafaa S.

doi:10.5507/bp.2016.034

Cited by 13 publications

(8 citation statements)

References 31 publications

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“…Cisplatin-induced oxidative stress is considered to be one of the main causes of myelosuppression. 13,26 As demonstrated in (G, H and I) of Fig. 7, the GSH-Px active level and serum SOD were lower while serum MDA was higher in the cisplatin group in comparison with the blank group proving that there was oxidative damage.…”

Section: Hwkl Reduces Cisplatin-induced Myelosuppressionmentioning

confidence: 87%

He-Wei granules (HWKL) combat cisplatin-induced nephrotoxicity and myelosuppression in rats by inhibiting oxidative stress, inflammatory cytokines and apoptosis

et al. 2017

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Section: Hwkl Reduces Cisplatin-induced Myelosuppressionmentioning

confidence: 87%

He-Wei granules (HWKL) combat cisplatin-induced nephrotoxicity and myelosuppression in rats by inhibiting oxidative stress, inflammatory cytokines and apoptosis

et al. 2017

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“…In 2013, it was reported that C. cassia powder (CP) (2, 10 and 100 mg/g per feed) protected against gastric ulcers induced by stress, ethanol or HCl through a cytoprotective mechanism [94]. Later, In 2016, El-Kady et al found that WEBC (10–50 μg/mL) resisted the cytotoxic effect of cis -diammine dichloroplatinum (CDDP) in vitro via preventing CDDP-induced increased expression of mitochondrial Bax protein, releasing of mitochondrial cytochrome c, caspase-3 activation, DNA fragmentation and generation of ROS, up-regulating expression of the cytoprotective gene (heme oxygenase (HO)-1) [95].…”

Section: Pharmacologymentioning

confidence: 99%

Cinnamomum cassia Presl: A Review of Its Traditional Uses, Phytochemistry, Pharmacology and Toxicology

et al. 2019

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Cinnamomum cassia Presl is a tropical aromatic evergreen tree of the Lauraceae family, commonly used in traditional Chinese medicine. It is also a traditional spice, widely used around the world. This paper summarizes the achievements of modern research on C. cassia, including the traditional uses, phytochemistry, pharmacology and toxicology. In addition, this review also discusses some significant issues and the potential direction of future C. cassia research. More than 160 chemicals have been separated and identified from C. cassia. The main constituents of C. cassia are terpenoids, phenylpropanoids, glycosides, etc. Modern studies have confirmed that C. cassia has a wide range of pharmacological effects, including antitumour, anti-inflammatory and analgesic, anti-diabetic and anti-obesity, antibacterial and antiviral, cardiovascular protective, cytoprotective, neuroprotective, immunoregulatory effects, anti-tyrosinase activity and other effects. However, the modern studies of C. cassia are still not complete and more in-depth investigations need to be conducted in alimentotherapy, health product, toxicity and side effects, and more bioactive components and potential pharmacological effects need to be explored in the future.

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“…Аналіз на тіазоліловий синій (МТТ) був використаний для вивчення життєздатності клітин та цитотоксичної активності екстрактів K. alvarezii (KAE, KAEA та KAC) у нормальних (клітинні лінії Vero) та клітинних лініях раку ротової порожнини (KB-3-1). Клітини Vero -це лінія нормальних фібробластів, отриманих від африканської зеленої мавпи, що широко використовується у дослідженнях цитотоксичності, росту та диференціації клітин (Elkady, Ramadan, 2016). Лінія KB-3-1 -це епідермоїдні клітини оральної карциноми людини (Dai et al, 2009).…”

Section: життєздатність клітин та цитотоксичні дослідженняunclassified

Phyto-pharmacological investigation of algae Kappaphycus alvarezii (Doty) Doty ex Silva for oral diseases (Rhodophyta)

Sharan¹,

Vennila²

2021

Algologia

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Oral infections (gingivitis and periodontitis) and oral cancer are under rise in developing countries. Products with antibacterial and antioxidant activity can provide a combined approach to treat oral disorders. Marine algae is a reservoir of rich bioactive phytochemicals and are considered to be potential candidates in natural pharmaceutics. Kappaphycus alvarezii is a marine algae widely cultivated for food applications. The current study investigates the phyto-pharmacological properties of K. alvarezii for oral diseases. Different polarity solvents (ethanol, ethyl acetate and chloroform) were used in the extraction of bioactive components of K. alvarezii, partially characterized by GCMS and studied for their antioxidant, antimicrobial and cytotoxic activity. All the K. alvarezii extracts exhibited good antioxidant activity and potential efficacy against oral pathogenic microbes. Although K. alvarezii extracts were found to be safe for normal Vero cells, their inhibitory activity on oral cancer cells (KB-3-1 cell lines) was found to be low. These findings have suggested the possibility of K. alvarezii using in the dental preparation/product to combat oral infections.

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The aqueous extract of cinnamon bark ameliorated cisplatin-induced cytotoxicity in vero cells without compromising the anticancer efficiency of cisplatin

Cited by 13 publications

References 31 publications

He-Wei granules (HWKL) combat cisplatin-induced nephrotoxicity and myelosuppression in rats by inhibiting oxidative stress, inflammatory cytokines and apoptosis

He-Wei granules (HWKL) combat cisplatin-induced nephrotoxicity and myelosuppression in rats by inhibiting oxidative stress, inflammatory cytokines and apoptosis

Cinnamomum cassia Presl: A Review of Its Traditional Uses, Phytochemistry, Pharmacology and Toxicology

Phyto-pharmacological investigation of algae Kappaphycus alvarezii (Doty) Doty ex Silva for oral diseases (Rhodophyta)

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