The aqueous extract of Hibiscus sabdariffa calices modulates the production of monocyte chemoattractant protein-1 in humans

Beltrán‐Debón, Raúl; Alonso-Villaverde, Carlos; Aragonès, Gerard; Rodríguez-Medina, Inmaculada C.; Rull, Anna; Micol, Vicente; Segura‐Carretero, Antonio; Fernández‐Gutiérrez, Alberto; Camps, Jordi; Joven, Jorge

doi:10.1016/j.phymed.2009.08.006

Cited by 92 publications

(77 citation statements)

References 31 publications

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“…Triglyceride concentration reduction could be because a reduction in VLDL concentrations, the major triglyceride-containing lipoprotein. This effect could be observed in other polyphenol-rich plant extracts (Beltrán-Debón et al, 2010). On the other hand, the higher cholesterol concentration after H. sabdariffa treatment could be explained by an increase in LDL and HDL concentrations.…”

Section: Effects Of H Sabdariffa Extract On Serum Lipid Concentrationsmentioning

confidence: 76%

“…Histological examination revealed that it could reduce foam cell formation and inhibit VSMC proliferation and migration, suggesting the anti-atherosclerotic effect of H. sabdariffa. In addition, studies on humans show the antihypertensive and anti-inflammatory effects of H. sabdariffa consumption (Beltrán-Debón et al, 2010;Herrera-Arellano, Flores-Romero, Chavez-Soto, & Tortoriello, 2004). The brilliant red color and unique flavor make it a valuable food product.…”

Section: Introductionmentioning

confidence: 99%

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Quantification of the polyphenolic fraction and in vitro antioxidant and in vivo anti-hyperlipemic activities of Hibiscus sabdariffa aqueous extract

Fernández-Arroyo

Rodríguez-Medina

Beltrán‐Debón

et al. 2011

Food Research International

104

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Section: Effects Of H Sabdariffa Extract On Serum Lipid Concentrationsmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Quantification of the polyphenolic fraction and in vitro antioxidant and in vivo anti-hyperlipemic activities of Hibiscus sabdariffa aqueous extract

Fernández-Arroyo

Rodríguez-Medina

Beltrán‐Debón

et al. 2011

Food Research International

104

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“…Another investigation about effects of H. sabdariffa L. extract powder and preventive diet in patients with metabolic syndrome showed antihypertensive and antihyperlipidemic impacts for this plant (40). Another study revealed that the aqueous extract of H. sabdariffa L. calices modulates the production of monocyte chemoattractant protein-1 in humans and lower production of mcp1, which means the slower development of atherosclerosis (41, 42). Also another study proved the effect of anthocyanin extracted from Hibiscus in attenuating oxidized LDL-mediated foam cell formation involving regulation of CD36 gene (43).…”

Section: Discussionmentioning

confidence: 99%

Effect of Hibiscus sabdariffa Calices on Dyslipidemia in Obese Adolescents: A Triple-masked Randomized Controlled Trial

Sabzghabaee¹,

Ataei²,

Kelishadi³

et al. 2013

Mater Sociomed

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Conflict of interest: none declared.ObjectiveWe aimed to evaluate the effects of Hibiscus sabdariffa (HS) calices on controlling dyslipidemia in obese adolescents.MethodologyIn this triple blind randomized placebo-controlled clinical trial which was registered in the Iranian registry for clinical trials (IRCT201109122306N2), 90 obese adolescents aged 12-18 years with documented dyslipidemia were randomly assigned in two groups of cases who received 2 grams of fine powdered calices of Hibiscus sabdariffa per day for one month and controls who received placebo powder with the same dietary and physical activity recommendations and duration of exposure. Full lipid profile and fasting blood sugar measured before and after the trial. Data were analyzed using multivariate general linear model.FindingsOverall, 72 participants (mean age of 14.21±1.6, 35 boys) completed the trial. The two arms of the study (cases and controls) were not statistically different in terms of age, gender, weight, body mass index (BMI) and lipid profile before the trial. Serum total cholesterol, low density lipoprotein cholesterol and serum triglyceride showed a significant decrease in cases group but high density lipoprotein cholesterol level was not changed significantly.ConclusionIt is concluded that Hibiscus sabdariffa calyces powder may have significant positive effects on lipid profile of adolescents which maybe attributed to its polyphenolic and antioxidant content. Further studies are needed on dose-response and formulation optimization.

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“…Whether such agents can be used in humans remains questionable because the effect of CCL2 suppression, as mentioned above, may not be absolutely safe. However, it may be possibly safer to transitorily decrease the expression of CCL2 with plant-derived flavonoids or interfere with CCL2-CCR2 interactions using small molecules currently under investigation for safety and effectiveness [87, 88]. Current studies are also being performed to test the hypothesis that metabolic disturbances may be alleviated through the modulation of CCL2 expression.…”

Section: The Role Of Ccl2 Regulating Inflammation and Metabolic DImentioning

confidence: 99%

Insulin Resistance, Inflammation, and Obesity: Role of Monocyte Chemoattractant Protein-1 (orCCL2) in the Regulation of Metabolism

Rull

Camps

Alonso-Villaverde

et al. 2010

Mediators of Inflammation

119

102

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To maintain homeostasis under diverse metabolic conditions, it is necessary to coordinate nutrient-sensing pathways with the immune response. This coordination requires a complex relationship between cells, hormones, and cytokines in which inflammatory and metabolic pathways are convergent at multiple levels. Recruitment of macrophages to metabolically compromised tissue is a primary event in which chemokines play a crucial role. However, chemokines may also transmit cell signals that generate multiple responses, most unrelated to chemotaxis, that are involved in different biological processes. We have reviewed the evidence showing that monocyte chemoattractant protein-1 (MCP-1 or CCL2) may have a systemic role in the regulation of metabolism that sometimes is not necessarily linked to the traffic of inflammatory cells to susceptible tissues. Main topics cover the relationship between MCP-1/CCL2, insulin resistance, inflammation, obesity, and related metabolic disturbances.

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The aqueous extract of Hibiscus sabdariffa calices modulates the production of monocyte chemoattractant protein-1 in humans

Cited by 92 publications

References 31 publications

Quantification of the polyphenolic fraction and in vitro antioxidant and in vivo anti-hyperlipemic activities of Hibiscus sabdariffa aqueous extract

Quantification of the polyphenolic fraction and in vitro antioxidant and in vivo anti-hyperlipemic activities of Hibiscus sabdariffa aqueous extract

Effect of Hibiscus sabdariffa Calices on Dyslipidemia in Obese Adolescents: A Triple-masked Randomized Controlled Trial

Insulin Resistance, Inflammation, and Obesity: Role of Monocyte Chemoattractant Protein-1 (orCCL2) in the Regulation of Metabolism

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