The architecture of cancer.

Waxman, Jonathan; Wasan, H.

doi:10.1136/bmj.305.6865.1306

Cited by 15 publications

(3 citation statements)

References 15 publications

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“…A major challenge for oncological practice is the identification of these patients with micrometastases at their initial presentation. The availability of more specific markers for micrometastases might then allow for the rational introduction of adjuvant chemotherapy or novel biological therapies and improve the prognosis (Waxman & Wasan, 1992).…”

mentioning

confidence: 99%

Serum metalloproteinases and their inhibitors: markers for malignant potential

Baker

Tickle²,

Wasan³

et al. 1994

Br J Cancer

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mentioning

confidence: 99%

Serum metalloproteinases and their inhibitors: markers for malignant potential

Baker

Tickle²,

Wasan³

et al. 1994

Br J Cancer

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“…It seems that it plays a critical role in the expression of genes as well: many DNA-binding proteins are zinc complexes. Zinc metalloproteins are also important for protecting the integrity of cell membranes and extracellular matrix architecture (Waxman and Wasan, 1992). Depending on the extent of zinc depletion, deficits in young mammals can lead to delayed growth, anorexia and severe diarrhea and skin lesions Casey and Walravens, 1988).…”

Section: Resultsmentioning

confidence: 99%

Some Macromineral and Trace Mineral Levels in Milk of Different Dog Breeds

SÖĞÜTLÜ¹,

Günbatar

Mert

et al. 2022

Turkish Journal of Veterinary Research

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Objective: In this study, it was planned to examine the mineral levels in the milk of different dog breeds during the lactation period. Calcium (Ca), magnesium (Mg), potassium (K), sodium (Na), copper (Cu), zinc (Zn), manganese (Mn) and iron (Fe) concentrations were analyzed in dog milk. Materials and methods:In this research 6 Labradors, 6 German Shepherds, 6 Pointers, 5 Turkish Tazis (sighthound), 5 Setters, 7 Malinois, and 5 Golden Retrievers (a total of 40 dogs) of 3 to 4 years of age were used as research materials, all of which were under same management and feeding conditions. All dogs were on diets appropriate for gestation and lactation periods. Adequate milk volume could be collected 2-3 weeks after parturition, and there were no known medical problems. Each day's samples were kept capped and refrigerated after being collected. The concentrations of calcium, magnesium, potassium, sodium, copper, zinc, manganese and iron, were analyzed by using Varian Brand 30/40 model AAS device. Results:The Ca, K, Na, Zn, Mn and Fe levels of milk samples from different dog breeds had no significant difference. The highest Mg level was determined in Pointer breed milk samples, and the lowest was determined in Setter milk samples. The highest Cu levels among the inspected races were in Labrador milk samples, whereas the lowest levels were determined in Setter breeds. Conclusion:This data shows that most of the analyzed milk content of different breeds of dogs did not change significantly during the same lactation period, and any present difference could be taken into account when evaluating breeding studies.

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“…MMP9 secretion by murine colonic, mammary, lung cancer and oncogenic transformed cell lines has been correlated with increased metastatic potential . Collagenolytic activity has been correlated with tumour grade and stage in colon cancer and;31 to tumour stage in invasive bladder cancer,32 and an increase in activity compared to normal tissue has been demonstrated in endometrial, ovarian, prostate, colorectal, gastric, breast and lung carcinomas . Stromelysin expression has also been shown to correlate with tumour progression in murine squamous cell carcinomas of the skin,36,37 and excess stromelysin activity has been recorded in the human form .…”

Section: Mmpsmentioning

confidence: 98%

Stromal degradation by the malignant epithelium in pancreatic cancer and the therapeutic potential of proteolytic inhibition

Bramhall

1998

Journal of Hepato-Biliary-Pancreatic Surgery

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off matrix metalloproteinases (MMPs) and the tissue inhibitors of the metalloproteinases (TIMPs) are described and reviewed. The role of the MMPs and their inhibitors in tumour invasion and metastasis is reviewed and the interaction between the extracellular matrix and these enzymes is discussed. The expression and activity of the MMPs and TIMPs in pancreatic cancer is reported with reference to the literature and the author's own work. The effect of MMP inhibitors (MMPIs) in vivo and the use of batimastat and marimastat (both; British Biotech Pharmaceuticals, Oxford, UK) in animal experiments are also described. Preliminary phase II and III clinical trial data of marimastat in advanced pancreatic cancer is reported.

show abstract

The architecture of cancer.

Cited by 15 publications

References 15 publications

Serum metalloproteinases and their inhibitors: markers for malignant potential

Serum metalloproteinases and their inhibitors: markers for malignant potential

Some Macromineral and Trace Mineral Levels in Milk of Different Dog Breeds

Stromal degradation by the malignant epithelium in pancreatic cancer and the therapeutic potential of proteolytic inhibition

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