ANALYTICAL METHODS AND PRACTICAL ASPECTS OF SAMPLE PREPARATION Over the last 15 years or so, two main methods have been developed for the analysis of Re-Os isotopes in BMS grains; (i) in situ laser ablation multi-collector inductively coupled plasma mass spectrometry (LA MC ICPMS) and (ii) sulfide extraction, chemical purification, and thermal ionization mass spectrometry (TIMS). Lead isotopes have also been measured using the TIMS technique, as well as by in situ secondary ion mass spectrometry (SIMS). There are distinct advantages and disadvantages associated with each analytical method, particularly with respect to sample preparation and interpretation of the information obtained. Early work on Pb, Re, Os, and other PGE concentrations in BMS grains was performed by in situ proton microprobe analysis coupled with a MC ICPMS (Bulanova et al. 1996; Guo et al. 1999). Due to limited availability and because detection limits were higher and standard reproducibility for this method was less precise, in situ determination of Re and PGE