The Arctic sponge Haliclona viscosa as a source of a wide array of 3-alkyl pyridine alkaloids

Retracted Article: The synthesis and biological activity of marine alkaloid derivatives and analogues

“…As aforementioned, natural products are compounds rich in biological activity that have the potential to be developed into drugs. [108][109][110][111] With the research and development of modern drugs, obtaining new drugs or lead compounds from marine organisms has become an important source. Marine sponges have been well studied and many biological activity compounds have been separated from these relatively simple organisms in recent years, including some new structural compounds.…”

Natural Products with Anti‐Bredt and Bridgehead Double Bonds

“…These include the saraines 1-3 (196-198), isosaraines 1-3 (199-201), haliclamines A-F (202-207), and halicyclamines A-B (208-210), which, unsurprisingly, are all biogenically linked. [154] The saraines 1-3 (196-198; Figure 37), [155] which bear a 3azabicyclo[10.3.1]hexadec-1-ene core, were isolated from the Mediterranean sponge Reniera sarai (order Haplosclerida) collected in the bay of Naples, Italy. In conjunction with extensive 2D NMR spectroscopy, reduction of the carbonyl moiety to the corresponding alcohols, followed by conversion into the Mosher esters facilitated structure determination.…”

Antibiotic activity and microbial community of the temperate sponge, Haliclona sp.

“…This selective pressure is thought to drive the evolution of natural products with potent bioactivity that may be exploited for pharmaceutical development (Laport et al 2009;Sepcic et al 2010). Sponges in the genus Haliclona are a particularly rich source of natural products, including amino alcohols (Devijver et al 2000), macrocyclic diamides (Jang et al 2009), sphingoid bases (Molinski et al 2013), steroids and terpenoids (Sakowicz et al 1998;Blackburn and Faulkner 2000;Volk and Kock 2003;Volk et al 2004;Yu et al 2006;Trianto et al 2011), alkaloids (Charan et al 1996;Clark et al 1998;Schmidt et al 2011Schmidt et al , 2012Kock et al 2013), hydroquinones (Bokesch et al 2002), acetylenes (Chill et al 2000;Nuzzo et al 2012), cyclic peptides (Randazzo et al 2001) and nucleosides (Wang et al 2009). When we began this study, we were interested in natural products from marine invertebrates in temperate habitats, as they are less studied than their tropical counterparts.…”