The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals

Grillová, Linda; Musilová, Jana; Janečková, Klára; Pospíšilová, Petra; Kuklová, Ivana; Woznicová, Vladana; Zákoucká, Hana; Šmajs, David

doi:10.1128/iai.00503-20

Cited by 4 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the previous work (Grillová et al (2020) [18]) on the Czech and Slovak populations identified the TLR2 Arg753Gln polymorphism as a possible protective factor against syphilis, our current study did not find this association. Nevertheless, a similar, but not statistically significant, trend was noticed in this study, where the control group had a higher prevalence of Arg753Gln heterozygotes (GA, Table 1) compared to the syphilis-positive participants.…”

Section: Discussioncontrasting

confidence: 97%

“…Despite an overall 3% frequency, its distribution differs greatly among various European populations. The highest frequency was found in the Czech and Slovak populations [18] and among a Turkish population [19], both around 10%. On the other hand, in southern Europe, this SNP has a low frequency [20].…”

Section: Introductionmentioning

confidence: 92%

“…There are only two previous studies on the role of the TLR2 Arg753Gln polymorphism in syphilis patients. A study by Grillová et al [18], which was performed on a Czech and Slovak population, revealed a significantly lower prevalence of the TLR2 Arg753Gln polymorphism among seropositive syphilis patients (4 patients with polymorphism and 133 patients with wild-type sequences) compared to healthy, seronegative individuals (24 individuals with polymorphism and 221 individuals with wild-type sequences) (p = 0.0065). These results suggested a protective effect of the TLR2 Arg753Gln polymorphism against the acquisition of syphilis infection.…”

Section: Introductionmentioning

confidence: 95%

See 2 more Smart Citations

The Arg753Gln Polymorphisms in Toll-like Receptor 2 in a Syphilis-Infected and Control Population in The Netherlands: Can Differences in the Number of Self-Reported Sexual Contacts Indicate Protection against Syphilis?

Vrbová,

Zondag,

Bruisten

et al. 2024

Venereology

View full text Add to dashboard Cite

The Arg753Gln polymorphism in Toll-like receptor 2 has been associated with an increased risk of bacterial infections as well as with protection from the late stages of Lyme disease and the acquisition of syphilis. In this study, we determined the presence of this polymorphism in samples collected from men having sex with men/men with women in the Amsterdam Cohort Studies. The presence of the polymorphism was determined by nested PCR, followed by Sanger sequencing. A set of 90 syphilis-seronegative individuals was compared to 95 syphilis-diagnosed participants. A polymorphism allele frequency of 3.9% was found in the control group and 2.63% in the syphilis case group, respectively. None of the individuals showed a homozygous Arg753Gln polymorphism. The number of self-reported sexual contacts was higher in the group of syphilis patients compared to the control group (p = 0.0063). Moreover, in the syphilis case group (n = 49), participants heterozygous for the TLR2-Arg753Gln reported higher numbers of sexual contacts (p = 0.037) compared to wild-type homozygotes. Our findings suggest a possible protective effect of TLR2-Arg753Gln in the acquisition of syphilis. In addition, the determination of the number of self-reported sexual contacts can be used in an evaluation of the protective effect of polymorphism in a population with a low prevalence of it.

show abstract

Section: Discussioncontrasting

confidence: 97%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

The Arg753Gln Polymorphisms in Toll-like Receptor 2 in a Syphilis-Infected and Control Population in The Netherlands: Can Differences in the Number of Self-Reported Sexual Contacts Indicate Protection against Syphilis?

Vrbová,

Zondag,

Bruisten

et al. 2024

Venereology

View full text Add to dashboard Cite

show abstract

“…The patients may also have genetic susceptibilities to STIs. Indeed there might be an association between genetic variants in host protein disulfide isomerase 2 and susceptibility to Chlamydia infection, between polymorphism in Toll-like receptor 2 and syphilis, and between susceptibility to Neisseria gonorrhoeae and human leukocyte antigen alleles and IL-2 polymorphism [20–22].…”

Section: Discussionmentioning

confidence: 99%

Incidence and risk factors for recurrent sexually transmitted infections among MSM on HIV pre-exposure prophylaxis

Zeggagh

Bauer

Delaugerre

et al. 2022

Aids

View full text Add to dashboard Cite

a,b , and the Ipergay Study Group Objective: High rates of sexually transmitted infections (STIs) have been reported among pre-exposure prophylaxis (PrEP) users. We wished to assess the incidence and risk factors for recurrent STIs. Design:The ANRS IPERGAY trial was a prospective study investigating PrEP among MSM and transgender women in outpatient clinics in France and Canada. In all, 429 participants were enrolled, offered up to 4 years of PrEP and screened for bacterial STIs (syphilis, chlamydia and gonorrhea) at baseline and every 6 months.Methods: STIs incidence was calculated yearly. Cox proportional hazards model regression was used to explore associations between participants characteristics at baseline and recurrent STI during follow-up.Results: Over a median follow-up of 23 months, bacterial STI incidence was 75, 33, 13, 32 and 30 per 100 person-years for all STIs, rectal STIs, syphilis, gonorrhea and chlamydia, respectively. STI incidence significantly increased from the first year to the fourth year of the study (55 vs. 90 per 100 person-years, P < 0.001). During the study period, 167 participants (39%) presented with more than one bacterial STIs which accounted for 86% of all STIs. Baseline risk factors associated with recurrent STIs in a multivariate analysis were an STI at baseline [hazards ratio: 1.48 (95% confidence interval (CI): 1.06-2.07), P ¼ 0.02], more than eight sexual partners in prior 2 months [hazards ratio: 1.72 (95% CI: 1.21-2.43), P ¼ 0.002] and the use of gamma-hydroxybutyrate [hazards ratio: 1.66 (95% CI: 1.16-2.38), P ¼ 0.005].

show abstract

“…In syphilis patients, the Arg753Gln change had a much lower frequency than in controls. The findings implied that Arg753Gln ( TLR2 ) does protect against syphilis development ( 16 ).…”

Section: Host Factors Associated With Sexually Transmitted Infectionsmentioning

confidence: 99%

The association of host genes with specific sexually transmitted infections

Bovungana,

Arumugam,

Ramsuran

2023

Front. Reprod. Health

View full text Add to dashboard Cite

Sexually transmitted infections (STIs) are hazardous to human health worldwide. STIs have a direct influence on sexual and reproductive health and can increase the chances of HIV. Globally, more than 1 million STIs are acquired every day and the majority are asymptomatic. Approximately, 374 million cases of STIs have been reported annually. The most prevalent STIs include chlamydia, gonorrhoea, syphilis, and trichomoniasis. These STIs are caused by Chlamydia trachomatis, Neisseria gonorrhoeae, Treponema pallidum and Trichomonas vaginalis. The major factor that contributes to the susceptibility and prognosis of infectious diseases is genetic variation. Host genes play a huge role in STIs and immune response. The production of host factors is stimulated by a variety of bacteria, viruses and parasites and the host factors can play a role in increasing host vulnerability to infection and pathogen persistence. Genetic variation or polymorphisms within certain host genes can influence the course of pathogen infection and disease progression. Polymorphisms can contribute to changes in gene expression and or changes in the protein structure. which may either contribute to/or protect against infection. This review discusses the role of host genes in influencing the susceptibility of the most prevalent STIs caused by Chlamydia trachomatis, Trichomonas vaginalis, Treponema pallidum and Neisseria gonorrhoeae. We evaluate polymorphisms associated pathogen recognition signalling pathway of these diseases. These polymorphisms may be used as biomarkers to infer risk to specific STIs.

show abstract

The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals

Cited by 4 publications

References 28 publications

The Arg753Gln Polymorphisms in Toll-like Receptor 2 in a Syphilis-Infected and Control Population in The Netherlands: Can Differences in the Number of Self-Reported Sexual Contacts Indicate Protection against Syphilis?

The Arg753Gln Polymorphisms in Toll-like Receptor 2 in a Syphilis-Infected and Control Population in The Netherlands: Can Differences in the Number of Self-Reported Sexual Contacts Indicate Protection against Syphilis?

Incidence and risk factors for recurrent sexually transmitted infections among MSM on HIV pre-exposure prophylaxis

The association of host genes with specific sexually transmitted infections

Contact Info

Product

Resources

About