The ‘ART’ of thrombosis: a review of arterial and venous thrombosis in assisted reproductive technology

Chan, Wee‐Shian

doi:10.1097/gco.0b013e328329c2b8

Cited by 112 publications

(101 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The median [IQR] ages of women were 38 [37][38][39][40][41] yr and 29 [25][26][27][28][29][30][31][32][33][34] yr in the AMA and non-AMA groups, respectively (Table 1). Other maternal demographic and obstetric characteristics were similar in both groups (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Women with an IVF pregnancy are at increased risk of VTE and arterial thrombosis as these patients are known to develop enhanced hypercoagulability due to ovarian hyperstimulation syndrome after IVF. 37 We defined AMA as maternal age [ 35 yr and non-AMA as maternal age B 35 yr. Our definition is slightly different from other studies that describe AMA as age C 35 yr. [4][5][6] Nevertheless, the AMA cut-off point is unlikely to have altered our main findings, especially as we did not observe significant correlations between any TEG variable and maternal age at the measured study time points. It is uncertain whether TEG is sufficiently sensitive to detect subtle differences in the degree of maternal hypercoagulability.…”

Section: Discussionmentioning

confidence: 99%

“…We used a linear mixed-effects regression model (SAS Ò PROC MIXED) to assess between-group differences for individual thromboelastographic and laboratory coagulation parameters. Results The median [interquartile range] ages of women were 38 [37][38][39][40][41] yr and 29 [25][26][27][28][29][30][31][32][33][34] yr in the AMA and non-AMA groups, respectively (P \ 0.001). We observed no statistically significant effect of study group on any thromboelastographic or laboratory coagulation parameters.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Impact de l’âge maternel avancé sur les profils de coagulation thrombo-élastographique du péripatum: une étude observationnelle prospective exploratoire

Butwick

Gutiérrez

Hilton

2014

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

Purpose Advanced maternal age (AMA) is a known risk factor for pregnancy-related venous thromboembolism. However, it is unclear if underlying differences exist in the maternal coagulation profiles of AMA vs non-AMA women. The aim of this prospective observational study was to compare peripartum thromboelastography parameters of AMA and non-AMA women undergoing elective Cesarean delivery (CD). [25][26][27][28][29][30][31][32][33][34] yr in the AMA and non-AMA groups, respectively (P \ 0.001). We observed no statistically significant effect of study group on any thromboelastographic or laboratory coagulation parameters. No statistically significant correlations were found between any thromboelastographic parameter and maternal age. Peripartum thromboelastography and coagulation profiles of healthy AMA and healthy non-AMA women up to 72 hr post-CD were also similar. Conclusion These data suggest that maternal thromboelastographic profiles of healthy AMA and non-AMA women undergoing elective CD are similar. The study was registered at ClinicalTrials.gov (identifier: NCT01416454). Methods

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Impact de l’âge maternel avancé sur les profils de coagulation thrombo-élastographique du péripatum: une étude observationnelle prospective exploratoire

Butwick

Gutiérrez

Hilton

2014

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

show abstract

“…Therefore, laboratory investigation of thrombophilia in asymptomatic women before assisted conception and those with ovarian hyperstimulation syndrome is considered not to be justified (10). Namely, although ovarian hyperstimulation is associated with an increased risk of VTE, the overall risk is small and estimated to be 0.1% per treatment cycle, a similar incidence as in women with pregnancy associated VTE (63,64).…”

Section: Women In Assisted Conception Proceduresmentioning

confidence: 99%

Laboratory Investigation of Thrombophilia / LABORATORIJSKO ISPITIVANJE TROMBOFILIJA

Margetić¹

2014

Journal of Medical Biochemistry

View full text Add to dashboard Cite

Summary: Laboratory investigation of thrombophilia is aimed at detecting the well-established hereditary and acquired causes of venous thromboembolism, including activated protein C resistance/factor V Leiden mutation, prothrombin G20210A mutation, deficiencies of the physiological anticoagulants antithrombin, protein C and protein S, the presence of antiphospholipid antibodies and increased plasma levels of homocysteine and coagulation factor VIII. In contrast, investigation of dysfibrinogenemia, a very rare thrombophilic risk factor, should only be considered in a patient with evidence of familial or recurrent thrombosis in the absence of all evaluated risk factors mentioned above. At this time, thrombophilia investigation is not recommended for other potential hereditary or acquired risk factors whose association with increased risk for thrombosis has not been proven sufficiently to date. In order to ensure clinical relevance of testing and to avoid any misinterpretation of results, laboratory investigation of thrombophilia should always be performed in accordance with the recommended guidelines on testing regarding the careful selection of patients, time of testing and assays and assay methods used. The aim of this review is to summarize the most important aspects on thrombophilia testing, including whom and when to test, what assays and assay methods to use and all other variables that should be considered when performing laboratory investigation of thrombophilia.Keywords: acquired risk factors, hereditary risk factors, laboratory investigation of thrombophilia, venous thromboembolism Sa`etak: Cilj laboratorijskog ispitivanja trombofilije je otkrivanje ve} ustanovljenih naslednih i ste~enih uzroka venskog tromboembolizma, me|u kojima su aktivirana rezistencija na protein C/mutacija faktora V Leiden, mutacija protrombina G20210A, deficijencija fiziolo{kih antikoagulanasa antitrombina, proteina C i proteina S, prisustvo antifosfolipidnih antitela i povi{enih nivoa homocisteina i faktora koagulacije VIII u plazmi. Nasuprot tome, ispitivanje disfibrinogenemije, veoma retkog faktora rizika za trombofiliju, treba uzeti u razmatranje samo kod pacijenata kod kojih postoje dokazi o porodi~noj ili rekurentnoj trombozi uz odsustvo svih navedenih faktora rizika. U ovom trenutku, ispitivanje trombofilije se ne preporu~uje za ostale potencijalne nasledne ili ste~ene faktore rizika, ~ija povezanost sa pove}anim rizikom za trombozu jo{ nije nedvosmisleno dokazana. Kako bi se obezbedila klini~ka relevantnost testiranja i izbeglo pogre{no tuma~enje rezultata, laboratorijsko ispitivanje trombofilije trebalo bi uvek vr{iti u skladu s preporukama za testiranje koje se odnose na pa`ljiv odabir pacijenata, vreme testiranja i testove i metode koji se koriste. Cilj ovog preglednog ~lanka je da se ukratko predstave najva`niji aspekti testiranja trombofilije, izme|u ostalog, koga i kada testirati, koje testove i metode upotrebiti i koje sve varijable treba uzeti u obzir prilikom laboratorijskog ispitivanja trombofilije.Klju~ne rije~i...

show abstract

“…Hemoconcentration with increase in blood coagulability is responsible for arterial and venous thrombotic phenomena in patients with OHSS (Chan WS et al, 2009). …”

Section: Hemodynamic Changesmentioning

confidence: 99%

Prevention and Treatment of Ovarian Hyperstimulation Syndrome

Grbavac¹,

Ljiljak²,

Kuna³

2012

Advances in Embryo Transfer

View full text Add to dashboard Cite

The ‘ART’ of thrombosis: a review of arterial and venous thrombosis in assisted reproductive technology

Cited by 112 publications

References 100 publications

Impact de l’âge maternel avancé sur les profils de coagulation thrombo-élastographique du péripatum: une étude observationnelle prospective exploratoire

Impact de l’âge maternel avancé sur les profils de coagulation thrombo-élastographique du péripatum: une étude observationnelle prospective exploratoire

Laboratory Investigation of Thrombophilia / LABORATORIJSKO ISPITIVANJE TROMBOFILIJA

Prevention and Treatment of Ovarian Hyperstimulation Syndrome

Contact Info

Product

Resources

About