The arthropathy of systemic sclerosis: a 12 month prospective clinical and imaging study

Montagna, G.; Sodano, A; Capurro, Vittorio; Malesci, D.; Valentini, Gabriele

doi:10.1007/s00256-004-0830-6

Cited by 95 publications

(87 citation statements)

References 16 publications

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“…They may appear years before clinical onset of arthritis and are considered highly sensible and specific for RA. In this decade, anti-CCP has evolved from being a diagnostic tool to a biological marker which allows understanding of the pathogenetic features of RA [2]. Also, it has been observed that anti-CCP positive RA occurs mainly in patients with shared-epitope alleles and characterizes more aggressive disease with higher radiological degree of joint destruction [3,4].…”

Section: Discussionmentioning

confidence: 99%

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Anti-cyclic citrullinated peptide antibodies in scleroderma patients

et al. 2012

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Anti-CCP (cyclic citrullinated peptide) is considered the most useful laboratory tool in the diagnosis of rheumatoid arthritis (RA). Some authors have also found this autoantibody in patients with scleroderma (SSc). The study aimed to investigate the prevalence of anti-CCP antibodies in SSc patients from Southern Brazil and their association with clinical and serological profile of the disease. We studied 76 patients with SSc and 100 healthy volunteers for presence of anti-CCP. SSc patients charts were reviewed for clinical and laboratory data. In the SSc group, the diffuse form was present in 20.5%; 62.8% had the limited form; 14.1% had overlap with systemic lupus or polymyositis and 2.5% had SSc sine scleroderma. Anti-CCP was found in nine of 78 (11.5%) SSc patients and in one of 100 healthy volunteers (p = 0.0054). No relationship was found with arthritis, skin Rodnan m score, esophageal dysmotility, myocarditis, pulmonary hypertension and lung fibrosis. Positive association was observed with arthralgias (p = 0.02). Also, no relationship was noted with the presence of anti-centromere antibodies, anti-Scl-70, anti-RNP or rheumatoid factor. Anti-CCP are more common in SSc patients than in controls. Arthralgias but not arthritis or rheumatoid factor are more frequent in anti-CCP positive patients.

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Section: Discussionmentioning

confidence: 99%

“…Musculoskeletal involvement is seen in 24-97% of the patients [1,2] and may present with arthritis, arthralgias, joint contractures, tenosynovitis, muscle atrophy and loss of joint function [3]. A symmetrical polyarthritis similar to rheumatoid arthritis (RA) can also be found characterizing an SSc-RA overlap syndrome [4].…”

Section: Introductionmentioning

confidence: 99%

Anti-cyclic citrullinated peptide antibodies in scleroderma patients

et al. 2012

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“…Radiographic studies in SSc and RA have shown that the commonly affected areas are the joints, soft tissue, and bones of the hands [13,14,[17][18][19]. However, radiographs exhibit some limitations regarding their sensitivity to detect early inflammatory changes, such as effusion or synovitis, and they cannot assess tendon damage.…”

Section: Introductionmentioning

confidence: 98%

“…Regarding systemic sclerosis (SSc), joint symptoms are reported by 24-97% of SSc patients during the course of their disease, and are frequently disabling [12][13][14][15][16]. Manifestations of SSc hand are ranging from arthralgias to frank arthritis, contractures, and tendon friction rubs [12].…”

Section: Introductionmentioning

confidence: 99%

A comparative study between ultrasonographic hand features in systemic sclerosis and rheumatoid arthritis patients: Relation to disease activity, clinical and radiological findings

Gohar

Ezzat

Naeem

et al. 2015

The Egyptian Rheumatologist

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“…The pathophysiological mechanism of arthritis resulting in cricoatytenoid joint fixation in scleroderma resembles RA. The synovium is infiltrated by lymphocytes and plasma cells, and fibrin deposits in the joint space lead to fibrous ankylosis [31].…”

Section: Discussionmentioning

confidence: 99%

Laryngeal Involvement in Connective Tissue Disorders. Is it Important for Patient Management?

Iacovou

Vlastarakos

Nikolopoulos³

2012

Indian J Otolaryngol Head Neck Surg

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Connective tissue disorders (CTDs) involve multiple organ systems and may have a significant impact on the overall health and quality of life of the affected individuals. The present paper aims to review the current knowledge on the laryngeal manifestations of CDTs, and describe the available diagnostic and treatment options. Systematic literature review in Medline and other database sources. Information from related books was also included. Prospective controlled, double-blind prospective, prospective, and transversal cohort studies, case series, case reports, systematic reviews, and consensus papers. Laryngeal involvement mostly occurs in rheumatoid arthritis (13-75% of patients). It is not uncommon in active and progressive clinical course, though can also occur in silent or inactive CDTs. The crico-arytenoid joint is the most commonly affected site. Common symptoms include throat pain, dyphonia and hoarseness. Careful clinical assessment of the larynx by flexible naso-endoscopy, video-stroboscopy, or direct laryngoscopy, and appropriate imaging are required for pertinent patient management. Stridor is a sign of a life-threatening condition, and may require prompt surgical intervention. However, mild symptomatology may mislead clinicians, and the related diagnosis may be significantly delayed. The current evidence as identified in the present study suggest that laryngeal manifestations of CDTs are often underdiagnosed, due to a range of nonspecific symptoms. A multidisciplinary team approach with ENT input is necessary to improve the overall patient management.

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The arthropathy of systemic sclerosis: a 12 month prospective clinical and imaging study

Abstract: This cross-sectional prospective study confirms that an arthropathy is common in SSc patients and shows that it is a major determinant of disability. A classification of radiological alterations into three specific patterns is proposed.

Cited by 95 publications

References 16 publications

Anti-cyclic citrullinated peptide antibodies in scleroderma patients

Anti-cyclic citrullinated peptide antibodies in scleroderma patients

A comparative study between ultrasonographic hand features in systemic sclerosis and rheumatoid arthritis patients: Relation to disease activity, clinical and radiological findings

Laryngeal Involvement in Connective Tissue Disorders. Is it Important for Patient Management?

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