The Aryl Hydrocarbon Receptor (AhR) as a Mediator of Adverse Immune Reactions

Impaired glucose and lipid metabolism in ageing aryl hydrocarbon receptor deficient mice

“…AHR is an important signaling molecule for immune responses, notably for the balance between inflammatory and regulatory T cell response, and for differentiation programs of innate immune cells (Kiss et al, 2011;[ 17 ] Lee et al, 2011[ 20 ]; Nguyen et al, 2013[ 24 ]; Stockinger et al, 2014[ 34 ]). Both persistent and strong activation by non-degradable molecules such as TCDD and complete lack of AHR impairs important functions (Esser C, 2014[ 10 ]). By now, it is recognized that there is a healthy level for AHR activated by physiological ligands.…”