The Asia-Pacific Clinical Practice Guidelines for the Management of Frailty

Dent, Elsa; Lien, Christopher Tsung Chien; Lim, Wee Shiong; Wong, Wan Ling; Wong, Chek Hooi; Ng, Tze Pin; Woo, Jean; Dong, Birong; Vega, Shelley de la; Poi, Philip Jun Hua; Kamaruzzaman, Shahrul Bahyah; Won, Chang Won; Chen, Liang Kung; Rockwood, Kenneth; Arai, Hidenori; Rodríguez‐Mañas, Leocadio; Cao, Li; Cesari, Matteo; Chan, Piu; Leung, Edward M. F.; Landi, Francesco; Fried, Linda P.; Morley, John E.; Vellas, Bruno; Flicker, Leon

doi:10.1016/j.jamda.2017.04.018

Cited by 478 publications

(510 citation statements)

References 251 publications

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“…A computerized algorithm has been developed to allow health professionals to recognize and treat frailty (82). The Asia Pacific Conference has developed guidelines for the treatment of frailty (83). A Mediterranean diet and polyphenols appear to decrease the chance of developing frailty (84)(85)(86)(87).…”

Section: Modern Geriatric Giantsmentioning

confidence: 99%

Geriatrics in the 21st century

Vellas

Morley

2018

The Journal of nutrition, health and aging

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Section: Modern Geriatric Giantsmentioning

confidence: 99%

Geriatrics in the 21st century

Vellas

Morley

2018

The Journal of nutrition, health and aging

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“…It is widely thought that the most important influences associated with the aetiology include, but not limited to, a reduction of anabolic hormones (testosterone, growth hormone, insulin-like growth factor-I (IGF-I)), muscular disuse, increased circulating concentrations of pro-inflammatory cytokines (particularly TNF-α and IL-6), oxidative stress due to the accumulation of free radicals, mitochondrial dysregulation of muscle cells, a decline in the number of α-motoneurons and low vitamin-D status [100][101][102][103][104]. Although a number of dietary interventions have previously been investigated for their efficacy in the management and/or prevention of physical frailty and sarcopenia [45][46][47][48][49], the role of dietary protein often receives much attention. Dietary protein intake stimulates muscle protein synthesis (MPS) and facilitates postprandial muscle protein accretion [105].…”

Section: Underlying Mechanisms Underpinning the Potential Benefits Ofmentioning

confidence: 99%

“…Both aerobic and resistance training attenuates the loss of lean body mass, increases muscle strength and ameliorates frailty in older adults [42][43][44]. Numerous dietary interventions have been extensively investigated, though most studies have focused on the efficacy of individual nutrients or supplements rather than dietary patterns [45][46][47][48][49]. However, it is plausible that many dietary factors, including individual nutrients and other non-nutrient bioactive constituents, individually and collectively, influence skeletal muscle functioning and body composition.…”

Section: Introductionmentioning

confidence: 99%

Mediterranean Diet attenuates risk of frailty and sarcopenia: New insights and future directions

McClure

Villani

2017

JCSM Clinical Reports

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Sarcopenia and physical frailty are associated with progressive disability and predictive of negative health outcomes. Dietary interventions are considered the cornerstone in the management of sarcopenic symptomology and physical frailty. However few studies have investigated preventative strategies. Moreover, most studies have focused on the efficacy of individual nutrients or supplements rather than dietary patterns. The Mediterranean Diet (MedDiet) is a dietary pattern that provides evidence for an association between diet quality, healthy ageing and disease prevention. The purpose of this paper was to examine, synthesise and develop a narrative review of the current literature, investigating the potential benefits associated with adherence to a MedDiet and attenuation of physical frailty and sarcopenic symptomology in older adults. We also explored the underlying mechanisms underpinning the potential benefits of the MedDiet on ameliorating physical frailty and sarcopenic symptomology. Synthesis of the reviewed literature is suggestive of a decreased risk of physical frailty and sarcopenic symptomology with greater adherence to a MedDiet. We identified the anti-inflammatory and high antioxidant components of the MedDiet as two potential biological mechanisms involved. Due to a lack of evidence from RCTs to support the proposed physiological mechanisms, we suggest investigating these observations in older adults with type 2 diabetes (T2DM) whom are vulnerable to physical frailty and disability. A number of biological mechanisms describing the pathway to disability in older adults with T2DM have been postulated with many of these mechanisms potentially mitigated with dietary interventions involving the MedDiet. Exploring these mechanisms with the use of well-designed, longer-term dietary intervention studies in older adults with an increased vulnerability to physical frailty and sarcopenia is warranted.

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“…While weight loss leads to the loss of muscle mass leading to sarcopenia, most persons with sarcopenia do not have excess weight loss as muscle loss is replaced by fat (5-8). Both weight loss and sarcopenia are major causes of the physical phenotype of frailty, but frailty should be considered a secondary nutritional condition (9)(10)(11)(12)(13)(14)(15)(16).…”

mentioning

confidence: 99%