2022
DOI: 10.1021/acssynbio.2c00005
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The Aspartic Protease Yps3p and Cell Wall Glucanase Scw10p Are Novel Determinants That Enhance the Secretion of the Antitumor Triterpenoid GA-HLDOA in Saccharomyces cerevisiae

Abstract: Efficient bioproduction of triterpenoids is gaining increasing interest because of their significant biological applications; however, the secretion and bioproduction of triterpenoids are hindered by untapped genetic determinants. In our previous study, we observed that different engineered Saccharomyces cerevisiae strains exhibit different abilities for secreting the antitumor triterpenoid ganoderic acid 3-hydroxy-lanosta-8,24-dien-26-oic acid (GA-HLDOA). In the present study, we performed comparative proteom… Show more

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“…133 Fang et al identified the aspartic protease genes YPS3 and the cell wall glucanase gene SCW10 as determinants enhancing GA-HLDOA secretion through comparative proteomics analyses, demonstrating their potential for improving triterpenoid production. 134…”
Section: Identification and Explanation Of Complex Triterpenoids Synt...mentioning
confidence: 99%
See 1 more Smart Citation
“…133 Fang et al identified the aspartic protease genes YPS3 and the cell wall glucanase gene SCW10 as determinants enhancing GA-HLDOA secretion through comparative proteomics analyses, demonstrating their potential for improving triterpenoid production. 134…”
Section: Identification and Explanation Of Complex Triterpenoids Synt...mentioning
confidence: 99%
“…Besides, engineering functional transporters in yeast to promote transmembrane transfer can alleviate toxic effects, eliminate feedback inhibition, and simplify extraction processes in industry . Fang et al identified the aspartic protease genes YPS3 and the cell wall glucanase gene SCW10 as determinants enhancing GA-HLDOA secretion through comparative proteomics analyses, demonstrating their potential for improving triterpenoid production …”
Section: Bottlenecks and Strategies Of Heterologous Module Regulationmentioning
confidence: 99%