The assay and the effect of testosterone on rats compared with those of other sexual hormones

Korenchevsky, V.; Dennison, Marjorie; Brovsin, Inna

doi:10.1042/bj0300558

Cited by 45 publications

(15 citation statements)

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“…Oestrone and oestradiol belong to this group. These hormones do not cause any considerable return towards normal of the atrophied prostate, penis and male preputial glands (or eveti of the female preputial glands, which always respond to the hormones of the previous group), although they produce a definite increase in the weight of the seminal vesicles (with specific histological changes in the latter and also in the coagulating glands and prostate [Korenchevsky & Dennison, 1935]).…”

Section: Partially Bisexual Hormonesmentioning

confidence: 97%

The action of testosterone propionate on normal adult female rats

Korenchevsky

Dennison

Hall

1937

Biochemical Journal

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] we have shown that the male sexual hormone testosterone and its ester, testosterone propionate, have a powerful effect on the organs of ovariectomized rats. In the present paper the effect of testosterone propionate on normal female rats is described. Technique The technique used was the same as that in our previous papers. Artificial testosterone propionate was prepared and supplied by Messrs Ciba Ltd. Large doses of 05 and 1F5 mg. daily were chosen in order to overcome the effect of any antagonistic hormones which might be present in the female organism. The experiment was performed on 16 rats belonging to 3 litters. The rats were divided in such a way that litter-mates were present in each of the 3 groups. The average final age of the rats was 98 days and the hormone was injected daily for 21 days. The weights of the organs are summarized in Table I. In order to economize space the weights per unit of body weight are not given, but, as in our previous papers, where the conclusions based on these differ from those obtained from the actual weights, this is mentioned in the text. The detailed histological results will be published elsewhere.

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Section: Partially Bisexual Hormonesmentioning

confidence: 97%

The action of testosterone propionate on normal adult female rats

Korenchevsky

Dennison

Hall

1937

Biochemical Journal

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“…35, pp, 63-67. 1940 Implantation of hormonal substances in the anterior chamber of the eye of rats. Proc.…”

Section: Ijterature Citedmentioning

confidence: 99%

Local maintenance of spermatogenesis by intratesticularly implanted pellets of testosterone in hypophysectomized rats

Dvoskin

1944

Am. J. Anat.

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The maintenance of spermatogenesis in hypophysectomized rats by means of the injection of androgen in oil was first reported by Wdsh, Cuyler and McCullagh in 1934. I n these experiments, spermatogenesis was maintained for 20 days by the daily injection of an extract of male urine. This finding was confirmed by Nelson and Gallagher ('36) who extended the period of maintenance to 39 days. Nelson ('3'7) obtained maintenance for 60 days, and later ('40) for 178 days. The animals sired litters during the latter part of the period of treatment. From control experiments in which it was found that fertility persisted in androgen-treated hypophysectoinized animals longer than did motility of sperm in androgen-treated castrates, Nelson ( '37) demonstrated that the androgen injections caused a true maintenance of spermatogenesis, not merely the prolongation of the life of the sperm which were present at the time of hypophysectomy.The injection of a large number of synthetic androgens which have not been found to occur in nature, as well as crystal-Foundation. of Philosophy, in the Faculty of Pure Science, Columbia University. 'Aided by a grant, administered by Dr. P. E. Smith, from the Rockefeller * Submitted in partial fulfillment of the requirements for the degree of Doctor TABLr; 1-Absolute and relative weights of ventral prostates and seminal vesicles of hypophysectomiaed (Hypx.), crnoperated normal and castrute rats. One group of hypophysoctomi2ed rats was untreated; the others, at the t h e the hypophysis was ablated, received implants of pellets which contained various percentages of testosterone. Autopsie8 were performed 20 days later except for the last two groups which were autopsied after 40 days. Relative Hypx.contr. = 11.00

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“…The biological and chemical position of trans-androstenediol between the male and the ovarian hormones has been emphasised by Tschopp [1935] and by Butenandt [1936]. Androstanediol and testosterone will also cause enlargement of the uterus of the adult ovariectomised rat [Korenchevsky, Dennison, and Simpson, 1935;Korenchevsky, Dennison, and Brovsin, 1936].…”

Section: Introductionmentioning

confidence: 99%

“…As regards the crystalline hormones, cestrone by itself will produce a pseudo-mucification of the epithelium [Robson, 1931], progesterone has no effect at all [Selye, Browne, and Collip, 1936 a], while the simultaneous administration of cestrone and progesterone will produce the full mucification which is found at the end of pregnancy [Selye, Browne, and Collip, 1936 b]. Korenchevsky and Dennison [1936] have shown that both androstanediol and testosterone can not only cause mucification of the vaginal epithelium directly, but also can modify-the action of cestrone when given in conjunction with it to produce complete mucification. In this respect, therefore, these two male hormone substances may be considered to have certain properties akin to those of progesterone but also others differing from them.…”

Section: Introductionmentioning

confidence: 99%

Multiple Activities of Androgenic Compounds

Deanesly

Parkes

1937

Exp Physiol

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1. Some multiple effects of male hormones are reviewed. 2. Trans‐androstenediol, dehydro‐androsterone, androstenedione, and testosterone will cause development of the uterus of the immature rabbit similar to that caused by œstrone. The most active of these, trans‐androstenediol, is about 1/2000 as active as œstrone by this test. 3. Trans‐androstenediol causes cornification of the vaginal epithelium of the ovariectomised rat; testosterone acetate and propionate have an effect similar to that of the free hormone, in causing mucification. 4. In an orthodox test for œstrogenic activity on a group of 20 ovariectomised mice, trans‐androstenediol was found to be about 1/10,000 as active as œstrone. 5. Trans‐androstenediol, testosterone, testosterone propionate, and androstanediol will not only prevent the development but also cause the disappearance of the characteristic X‐zone in the adrenal cortex of castrated mice, according to the time after castration at which the injections are made. 6. Trans‐androstenediol, testosterone, trans‐dehydroandrosterone, and androstenedione, but not androstanediol in the dosage used, will feminise the plumage of the Sebright capon. We are much indebted to Dr K. Miescher and Messrs Ciba for their continued assistance in generously supplying the crystalline compounds used in the work described above.

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The assay and the effect of testosterone on rats compared with those of other sexual hormones

Cited by 45 publications

References 4 publications

The action of testosterone propionate on normal adult female rats

The action of testosterone propionate on normal adult female rats

Local maintenance of spermatogenesis by intratesticularly implanted pellets of testosterone in hypophysectomized rats

Multiple Activities of Androgenic Compounds

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